MOB-like protein phocein - Homo sapiens

MOB-like protein phocein (Homo sapiens)

FASTA TEXT XML

Subcellular Location Biology & Function Interactions Cross-References

General Information

Protein Information
Protein Name	MOB-like protein phocein
Accession Code	Q9Y3A3
Gene	MOB4
Organism	Homo sapiens \| Human (Taxonomy: 9606)
Part of Reference Proteome?	Yes
Sequence (Length: 225)
MVMAEGTAVLRRNRPGTKAQDFYNWPDESFDEMDSTLAVQQYIQQNIRADCSNIDKILEPPEGQDEGVWKYEHLRQFCLE LNGLAVKLQSECHPDTCTQMTATEQWIFLCAAHKTPKECPAIDYTRHTLDGAACLLNSNKYFPSRVSIKESSVAKLGSVC RRIYRIFSHAYFHHRQIFDEYENETFLCHRFTKFVMKYNLMSKDNLIVPILEEEVQNSVSGESEA

Structure Viewer (PDB: 7K36)

Subcellular Location

Description
Cytoplasm, perinuclear region {Experimental EvidencePubMed:11319234}. Membrane {Experimental EvidencePubMed:11319234}; Peripheral membrane protein {Experimental EvidencePubMed:11319234}. Golgi apparatus, Golgi stack membrane {Experimental EvidencePubMed:11319234}; Peripheral membrane protein {Experimental EvidencePubMed:11319234}. Note=In a perinuclear punctate pattern. Associated with membranes and the Golgi stacks.
Position in the Nuclear Envelope
Location	Location ID	Description
Perinuclear Region	SL-0198	The perinuclear region is the cytoplasmic region just around the nucleus.
Membrane Topology
Topology	Source	Annotation Type
Peripheral	UniProt	Experimental Evidence {ECO:0000269\|PubMed:11319234}
Assigned Ontology terms

Cellular Component	Cytoplasm (GO:0005737) Cytosol (GO:0005829) Dendritic Spine (GO:0043197) Golgi Apparatus (GO:0005794) Golgi Cisterna Membrane (GO:0032580) Neuronal Cell Body (GO:0043025) Perinuclear Region Of Cytoplasm (GO:0048471)

Biology & Function

Description
May play a role in membrane trafficking, specifically in membrane budding reactions. {By Similarity}.
Assigned Ontology terms

Biological Process
Molecular Function	Kinase Binding (GO:0019900) Metal Ion Binding (GO:0046872)

Protein-Protein Interactions

Interactions with Nuclear Envelope proteins (4 interactors)

Partner (NucEnvDB)		IntAct	Confidence score
Q6P5Z2	Serine/threonine-protein kinase N3	EBI-11918474	0.00
Q9Y4G8	Rap guanine nucleotide exchange factor 2	EBI-3450242	0.00
P00533	Epidermal growth factor receptor	EBI-4397868	0.55
Q13459	Unconventional myosin-IXb	EBI-737438	0.00
Interactions with other proteins (96 interactors)

Partner (UniProt)		IntAct	Confidence score
P49736	DNA replication licensing factor MCM2 (EC 3.6.4.12) (Minichromosome maintenance protein 2 homolog) (Nuclear protein BM28)	EBI-730585	0.00
P22234	Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase (PAICS) [Includes: Phosphoribosylaminoimidazole carboxylase (EC 4.1.1.21) (AIR carboxylase) (AIRC); Phosphoribosylaminoimidazole succinocarboxamide synthetase (EC 6.3.2.6) (SAICAR synthetase)]	EBI-730588	0.00
Q13332	Receptor-type tyrosine-protein phosphatase S (R-PTP-S) (EC 3.1.3.48) (Receptor-type tyrosine-protein phosphatase sigma) (R-PTP-sigma)	EBI-730591	0.00
Q5UIP0	Telomere-associated protein RIF1 (Rap1-interacting factor 1 homolog)	EBI-730594	0.00
Q9Y3C7	Mediator of RNA polymerase II transcription subunit 31 (Mediator complex subunit 31) (Mediator complex subunit SOH1) (hSOH1)	EBI-732941	0.00
O60383	Growth/differentiation factor 9 (GDF-9)	EBI-732944	0.00
Q9ULH0	Kinase D-interacting substrate of 220 kDa (Ankyrin repeat-rich membrane-spanning protein)	EBI-732947	0.00
P60660	Myosin light polypeptide 6 (17 kDa myosin light chain) (LC17) (Myosin light chain 3) (MLC-3) (Myosin light chain alkali 3) (Myosin light chain A3) (Smooth muscle and nonmuscle myosin light chain alkali 6)	EBI-732950	0.00
Q96GD3	Polycomb protein SCMH1 (Sex comb on midleg homolog 1)	EBI-732953	0.00
Q15047	Histone-lysine N-methyltransferase SETDB1 (EC 2.1.1.366) (ERG-associated protein with SET domain) (ESET) (Histone H3-K9 methyltransferase 4) (H3-K9-HMTase 4) (Lysine N-methyltransferase 1E) (SET domain bifurcated 1)	EBI-732956	0.00
Q15819	Ubiquitin-conjugating enzyme E2 variant 2 (DDVit 1) (Enterocyte differentiation-associated factor 1) (EDAF-1) (Enterocyte differentiation-promoting factor 1) (EDPF-1) (MMS2 homolog) (Vitamin D3-inducible protein)	EBI-732959	0.00
Q14194	Dihydropyrimidinase-related protein 1 (DRP-1) (Collapsin response mediator protein 1) (CRMP-1) (Inactive dihydropyrimidinase) (Unc-33-like phosphoprotein 3) (ULIP-3)	EBI-735462	0.00
Q13158	FAS-associated death domain protein (FAS-associating death domain-containing protein) (Growth-inhibiting gene 3 protein) (Mediator of receptor induced toxicity)	EBI-735465	0.00
Q9BTT4	Mediator of RNA polymerase II transcription subunit 10 (Mediator complex subunit 10) (Transformation-related gene 17 protein) (TRG-17) (Transformation-related gene 20 protein) (TRG-20)	EBI-735468	0.00
Q9Y4G2	Pleckstrin homology domain-containing family M member 1 (PH domain-containing family M member 1) (162 kDa adapter protein) (AP162)	EBI-735471	0.00
Q96KS0	Prolyl hydroxylase EGLN2 (EC 1.14.11.-) (Egl nine homolog 2) (EC 1.14.11.29) (Estrogen-induced tag 6) (EIT-6) (HPH-3) (Hypoxia-inducible factor prolyl hydroxylase 1) (HIF-PH1) (HIF-prolyl hydroxylase 1) (HPH-1) (Prolyl hydroxylase domain-containing protein 1) (PHD1)	EBI-737429	0.00
P19419	ETS domain-containing protein Elk-1	EBI-737432	0.00
P23142	Fibulin-1 (FIBL-1)	EBI-737435	0.00
Q15831	Serine/threonine-protein kinase STK11 (EC 2.7.11.1) (Liver kinase B1) (LKB1) (hLKB1) (Renal carcinoma antigen NY-REN-19)	EBI-737441	0.00
Q8WY91	Peroxynitrite isomerase THAP4 (EC 5.99.-.-) (Ferric Homo sapiens nitrobindin) (Hs-Nb(III)) (THAP domain-containing protein 4)	EBI-737444	0.00
O94989	Rho guanine nucleotide exchange factor 15 (Ephexin-5) (E5) (Vsm-RhoGEF)	EBI-752704	0.37
Q15834	Coiled-coil domain-containing protein 85B (Hepatitis delta antigen-interacting protein A) (Delta-interacting protein A)	EBI-759730	0.37
Q9Y6E0	Serine/threonine-protein kinase 24 (EC 2.7.11.1) (Mammalian STE20-like protein kinase 3) (MST-3) (STE20-like kinase MST3) [Cleaved into: Serine/threonine-protein kinase 24 36 kDa subunit (Mammalian STE20-like protein kinase 3 N-terminal) (MST3/N); Serine/threonine-protein kinase 24 12 kDa subunit (Mammalian STE20-like protein kinase 3 C-terminal) (MST3/C)]	EBI-2480091	0.74
Q8TDY2	RB1-inducible coiled-coil protein 1 (FAK family kinase-interacting protein of 200 kDa) (FIP200)	EBI-1061436	0.00
Q9NZ47	HCG1811444 (Uncharacterized hematopoietic stem/progenitor cells protein MDS027) (cDNA FLJ76545, highly similar to Homo sapiens uncharacterized hematopoietic stem/progenitor cells protein MDS027 mRNA)	EBI-1061519	0.00
Q9Y376	Calcium-binding protein 39 (MO25alpha) (Protein Mo25)	EBI-1062295	0.00
P40337	von Hippel-Lindau disease tumor suppressor (Protein G7) (pVHL)	EBI-1062909	0.00
Q9Y5L4	Mitochondrial import inner membrane translocase subunit Tim13	EBI-1063567	0.00
Q9P031	Thyroid transcription factor 1-associated protein 26 (TTF-1-associated protein 26) (Coiled-coil domain-containing protein 59) (TTF-1-associated protein BR2)	EBI-1070283	0.00
P23508	Colorectal mutant cancer protein (Protein MCC)	EBI-1077095	0.00
P67775	Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform (PP2A-alpha) (EC 3.1.3.16) (Replication protein C) (RP-C)	EBI-1773521	0.77
P62714	Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform (PP2A-beta) (EC 3.1.3.16)	EBI-1773687	0.64
P30153	Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform (Medium tumor antigen-associated 61 kDa protein) (PP2A subunit A isoform PR65-alpha) (PP2A subunit A isoform R1-alpha)	EBI-2479208	0.71
Q59GV6	Zinedin variant	EBI-1774238	0.35
Q9P289	Serine/threonine-protein kinase 26 (EC 2.7.11.1) (MST3 and SOK1-related kinase) (Mammalian STE20-like protein kinase 4) (MST-4) (STE20-like kinase MST4) (Serine/threonine-protein kinase MASK)	EBI-1774238	0.76
O43815	Striatin	EBI-2476554	0.74
P63167	Dynein light chain 1, cytoplasmic (8 kDa dynein light chain) (DLC8) (Dynein light chain LC8-type 1) (Protein inhibitor of neuronal nitric oxide synthase) (PIN)	EBI-1774238	0.53
Q9ULQ0	Striatin-interacting protein 2 (Protein FAM40B)	EBI-2479515	0.46
Q13033	Striatin-3 (Cell cycle autoantigen SG2NA) (S/G2 antigen)	EBI-2476710	0.77
Q9NVK5	FGFR1 oncogene partner 2	EBI-2480091	0.53
Q5VSL9	Striatin-interacting protein 1 (Protein FAM40A)	EBI-1774238	0.53
A8K3H8	cDNA FLJ77680, highly similar to Homo sapiens protein phosphatase 2 (formerly 2A), regulatory subunit A (PR 65), alpha isoform (PPP2R1A), mRNA	EBI-1774238	0.35
Q14BN4	Sarcolemmal membrane-associated protein (Sarcolemmal-associated protein)	EBI-2479515	0.67
Q8WZ74	Cortactin-binding protein 2 (CortBP2)	EBI-1774238	0.60
Q9P2B4	CTTNBP2 N-terminal-like protein	EBI-1774238	0.73
Q9BRV8	Suppressor of IKBKE 1 (Suppressor of IKK-epsilon)	EBI-2479515	0.60
Q9Y228	TRAF3-interacting JNK-activating modulator (TRAF3-interacting protein 3)	EBI-2476666	0.50
Q9NRL3	Striatin-4 (Zinedin)	EBI-2479446	0.46
P30154	Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform (PP2A subunit A isoform PR65-beta) (PP2A subunit A isoform R1-beta)	EBI-2479515	0.46
O55106	Striatin	EBI-2479967	0.54
P40227	T-complex protein 1 subunit zeta (TCP-1-zeta) (Acute morphine dependence-related protein 2) (CCT-zeta-1) (HTR3) (Tcp20)	EBI-2480091	0.35
Q9BUL8	Programmed cell death protein 10 (Cerebral cavernous malformations 3 protein) (TF-1 cell apoptosis-related protein 15)	EBI-2480091	0.35
Q99832	T-complex protein 1 subunit eta (TCP-1-eta) (CCT-eta) (HIV-1 Nef-interacting protein) [Cleaved into: T-complex protein 1 subunit eta, N-terminally processed]	EBI-2480091	0.35
P48643	T-complex protein 1 subunit epsilon (TCP-1-epsilon) (CCT-epsilon)	EBI-2480091	0.35
O00506	Serine/threonine-protein kinase 25 (EC 2.7.11.1) (Ste20-like kinase) (Sterile 20/oxidant stress-response kinase 1) (SOK-1) (Ste20/oxidant stress response kinase 1)	EBI-2480091	0.64
P17987	T-complex protein 1 subunit alpha (TCP-1-alpha) (CCT-alpha)	EBI-2480091	0.35
Q92526	T-complex protein 1 subunit zeta-2 (TCP-1-zeta-2) (CCT-zeta-2) (CCT-zeta-like) (TCP-1-zeta-like) (Testis-specific Tcp20) (Testis-specific protein TSA303)	EBI-2480091	0.35
P49368	T-complex protein 1 subunit gamma (TCP-1-gamma) (CCT-gamma) (hTRiC5)	EBI-2480091	0.35
P78371	T-complex protein 1 subunit beta (TCP-1-beta) (CCT-beta)	EBI-2480091	0.35
P50990	T-complex protein 1 subunit theta (TCP-1-theta) (CCT-theta) (Chaperonin containing T-complex polypeptide 1 subunit 8) (Renal carcinoma antigen NY-REN-15)	EBI-2480091	0.35
Q99JT2	Serine/threonine-protein kinase 26 (EC 2.7.11.1) (Mammalian STE20-like protein kinase 4) (MST-4) (STE20-like kinase MST4) (Serine/threonine-protein kinase MST4)	EBI-2480319	0.35
Q9UGI0	Ubiquitin thioesterase ZRANB1 (EC 3.4.19.12) (TRAF-binding domain-containing protein) (hTrabid) (Zinc finger Ran-binding domain-containing protein 1)	EBI-2511131	0.40
P63168	Dynein light chain 1, cytoplasmic (8 kDa dynein light chain) (DLC8) (Dynein light chain LC8-type 1) (Protein inhibitor of neuronal nitric oxide synthase) (PIN) (mPIN)	EBI-2556165	0.40
Q86WH2	Ras association domain-containing protein 3	EBI-6912050	0.35
Q13188	Serine/threonine-protein kinase 3 (EC 2.7.11.1) (Mammalian STE20-like protein kinase 2) (MST-2) (STE20-like kinase MST2) (Serine/threonine-protein kinase Krs-1) [Cleaved into: Serine/threonine-protein kinase 3 36kDa subunit (MST2/N); Serine/threonine-protein kinase 3 20kDa subunit (MST2/C)]	EBI-8799700	0.48
Q13043	Serine/threonine-protein kinase 4 (EC 2.7.11.1) (Mammalian STE20-like protein kinase 1) (MST-1) (STE20-like kinase MST1) (Serine/threonine-protein kinase Krs-2) [Cleaved into: Serine/threonine-protein kinase 4 37kDa subunit (MST1/N); Serine/threonine-protein kinase 4 18kDa subunit (MST1/C)]	EBI-8799766	0.27
Q76MZ3	Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform (PP2A subunit A isoform PR65-alpha) (PP2A subunit A isoform R1-alpha)	EBI-10991736	0.35
P63330	Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform (PP2A-alpha) (EC 3.1.3.16)	EBI-11049240	0.35
Q91YI4	Beta-arrestin-2 (Arrestin beta-2)	EBI-11102575	0.35
Q8C079	Striatin-interacting protein 1 (Protein FAM40A)	EBI-11110036	0.35
Q9ERG2	Striatin-3 (Cell cycle autoantigen SG2NA) (S/G2 antigen)	EBI-11110170	0.35
O15259	Nephrocystin-1 (Juvenile nephronophthisis 1 protein)	EBI-11365282	0.27
Q9BPU9	B9 domain-containing protein 2 (MKS1-related protein 2)	EBI-11377507	0.27
O95684	Centrosomal protein 43 (FGFR1 oncogene partner)	EBI-11381827	0.27
Q15154	Pericentriolar material 1 protein (PCM-1) (hPCM-1)	EBI-11382763	0.27
Q68CZ1	Protein fantom (Nephrocystin-8) (RPGR-interacting protein 1-like protein) (RPGRIP1-like protein)	EBI-11386978	0.27
Q6ZU80	Centrosomal protein of 128 kDa (Cep128)	EBI-11388429	0.27
Q86SG6	Serine/threonine-protein kinase Nek8 (EC 2.7.11.1) (Never in mitosis A-related kinase 8) (NimA-related protein kinase 8) (Nima-related protein kinase 12a)	EBI-11389773	0.27
Q96ST8	Centrosomal protein of 89 kDa (Cep89) (Centrosomal protein 123) (Cep123) (Coiled-coil domain-containing protein 123)	EBI-11396670	0.27
Q9C0F1	Centrosomal protein of 44 kDa (Cep44) (HBV PreS1-transactivated protein 3) (PS1TP3)	EBI-11397104	0.27
Q9HC77	Centromere protein J (CENP-J) (Centrosomal P4.1-associated protein) (LAG-3-associated protein) (LYST-interacting protein 1)	EBI-11397411	0.27
P40454	Serine/threonine-protein phosphatase 2A activator 1 (EC 5.2.1.8) (Peptidyl-prolyl cis-trans isomerase PTPA-1) (PPIase PTPA-1) (Rotamase PTPA-1) (Phosphotyrosyl phosphatase activator 1)	EBI-11531126	0.56
P62195	26S proteasome regulatory subunit 8 (26S proteasome AAA-ATPase subunit RPT6) (Proteasome 26S subunit ATPase 5) (Proteasome subunit p45) (Thyroid hormone receptor-interacting protein 1) (TRIP1) (p45/SUG)	EBI-21656272	0.35
P19438	Tumor necrosis factor receptor superfamily member 1A (Tumor necrosis factor receptor 1) (TNF-R1) (Tumor necrosis factor receptor type I) (TNF-RI) (TNFR-I) (p55) (p60) (CD antigen CD120a) [Cleaved into: Tumor necrosis factor receptor superfamily member 1A, membrane form; Tumor necrosis factor-binding protein 1 (TBPI)]	EBI-21717945	0.35
Q9GZV8	PR domain zinc finger protein 14 (EC 2.1.1.-) (PR domain-containing protein 14)	EBI-21754819	0.35
P20155	Serine protease inhibitor Kazal-type 2 (Acrosin-trypsin inhibitor) (Epididymis tissue protein Li 172) (HUSI-II)	EBI-21762493	0.35
Q9Y343	Sorting nexin-24	EBI-21763225	0.35
P20933	N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase (EC 3.5.1.26) (Aspartylglucosaminidase) (Glycosylasparaginase) (N4-(N-acetyl-beta-glucosaminyl)-L-asparagine amidase) [Cleaved into: Glycosylasparaginase alpha chain; Glycosylasparaginase beta chain]	EBI-21878313	0.35
Q08379	Golgin subfamily A member 2 (130 kDa cis-Golgi matrix protein) (GM130) (GM130 autoantigen) (Golgin-95)	EBI-16792938	0.27
P13569	Cystic fibrosis transmembrane conductance regulator (CFTR) (ATP-binding cassette sub-family C member 7) (Channel conductance-controlling ATPase) (EC 5.6.1.6) (cAMP-dependent chloride channel)	EBI-25417249	0.35
P17813	Endoglin (CD antigen CD105)	EBI-22197897	0.35
Q5NHT8	Chaperone protein HtpG (Heat shock protein HtpG) (High temperature protein G)	EBI-22298716	0.37
A0A0H3LAM7	DUF732 domain-containing protein	EBI-25401616	0.35
Q13555	Calcium/calmodulin-dependent protein kinase type II subunit gamma (CaM kinase II subunit gamma) (CaMK-II subunit gamma) (EC 2.7.11.17)	EBI-28939534	0.35
Q8N4C8	Misshapen-like kinase 1 (EC 2.7.11.1) (GCK family kinase MiNK) (MAPK/ERK kinase kinase kinase 6) (MEK kinase kinase 6) (MEKKK 6) (Misshapen/NIK-related kinase) (Mitogen-activated protein kinase kinase kinase kinase 6)	EBI-28943316	0.35
Q9UKE5	TRAF2 and NCK-interacting protein kinase (EC 2.7.11.1)	EBI-28946906	0.35

Cross-References

Database	Links
UNIPROT	Q9Y3A3 B4DML0 Q53SE0 Q7Z4Y6 Q9H2P3 Q9H5J1 Q9Y4T8
PDB	5YF4 7K36
Pfam	PF03637
OMIM	609361
DisGeNET	25843

MOB-like protein phocein (Homo sapiens)

General Information

Protein Information

Structure Viewer (PDB: 7K36)

Subcellular Location

Description Show

Position in the Nuclear Envelope

Membrane Topology

Assigned Ontology terms

Biology & Function

Description Hide

Assigned Ontology terms

Protein-Protein Interactions

Interactions with Nuclear Envelope proteins (4 interactors)

Interactions with other proteins (96 interactors)

Cross-References

Database

Links

Description

Description