NucEnvDB

NucEnvDB

A database of Nuclear Envelope Proteins and their Interactions

Phospholipase D1 - Mus musculus - NucEnvDB

Phospholipase D1 (Mus musculus)

FASTA TEXT XML

Subcellular Location Biology & Function Disease Associations Interactions Cross-References

General Information

Protein Information
Protein Name	Phospholipase D1
Accession Code	Q9Z280
Gene	Pld1
Organism	Mus musculus \| House mouse (Taxonomy: 10090)
Part of Reference Proteome?	Yes
Sequence (Length: 1074)
MSLKSETRVNTSTLQKIAADMSNLIENLDTRELHFEGEEVEYDASPGDPKAQEGCIPFSSIYNTQGFKEPNIQTYLSGCPIKAQVLEVERFTSTSRVPSINLYTIELTHGEFTWQVKRKFKHFQEFHREL LKYKAFIRIPIPTKRHTFRRQNVKEEPREMPSLPRSSENAIQEEQFFGRRKQLEDYLTKILKMPMYRNYHATTEFLDVSQLSFIHDLGPKGLEGMIMKRSGGHRIPGVNCCGHGRACYRWSKRWLIVKDS FLLYMKPDSGAIAFVLLVDKEFRVKVGRKETETKYGLRIDNLSRTLILKCNSYRHARWWGGAIEEFIRKHGADFLKDHRFGSYAALHENTLAKWYVNAKGYFEDIANAMEEASEEIFITDWWLSPEIFLK RPVVEGNRWRLDCILKRKAQQGVRIFIMLYKEVELALGINSEYSKRTLMRLHPNIKVMRHPDHVSSSVYLWAHHEKLVIIDQSVAFVGGIDLAYGRWDDNEHRLTDVGSVKRVTSGLSLGSLTAASVESM ESLSLKDKHEFHKKEPISKIVDETDMKLKGIGKSRKFSKFSLYRQLHRHHLHNADSISSIDSTSSYFSHCRSHQNLIHGLKPHLKLFHPSSESEQGLTRHSTDTGSIRSVQTGVGELHGETRFWHGKDYC NFVFKDWVQLDKPFADFIDRYSTPRMPWHDIGSVVHGKAARDVARHFIQRWNFTKIMKPKYRSLSYPFLLPKSQATAHELRYQVPGAVPAKVQLLRSAADWSAGIKHHEESIHAAYIHVIENSKHYIYIE NQFFISCADDKVVFNKVGDRIAQRILKAHREGQRYRVYIVIPLLPGFEGDISTGGGNALQAIMHFNYRTMCRGESSILEQLKPELGNKWINYISFCGLRTHAELEGNLVTELIYVHSKLLIADDNTVIIG SANINDRSMLGKRDSEMAVIVQDTETVPSVMDGKEYQAGRFARDLRLECFRLVLGYLSDPSEDLQDPVSDKFFKEIWVSTAARNATIYDKVFRCLPNDEVHNLIQLRDFINKPILAKEDALRAEEELRKI RGFLVQFPLYFLSEENLLPSVGTKEAIVPMEVWT

Subcellular Location

Description
Cytoplasm, perinuclear region {Experimental EvidencePubMed:9395408}. Endoplasmic reticulum membrane {Curator Inference}; Lipid-anchor {Curator Inference}; Cytoplasmic side {Curator Inference}. Golgi apparatus membrane {Curator Inference}; Lipid-anchor {Curator Inference}; Cytoplasmic side {Curator Inference}. Late endosome membrane {Curator Inference}; Lipid-anchor {Curator Inference}; Cytoplasmic side {Curator Inference}.
Position in the Nuclear Envelope
Location	Location ID	Description
Perinuclear Region	SL-0198	The perinuclear region is the cytoplasmic region just around the nucleus.
Membrane Topology
Topology	Source	Annotation Type
Lipid-Anchored	UniProt	By Similarity {ECO:0000250}
Assigned Ontology terms

Cellular Component	Apical Plasma Membrane (GO:0016324) Cholinergic Synapse (GO:0098981) Endocytic Vesicle (GO:0030139) Endoplasmic Reticulum Membrane (GO:0005789) Endosome (GO:0005768) Golgi Apparatus (GO:0005794) Golgi Cisterna (GO:0031985) Golgi Membrane (GO:0000139) Intracellular Membrane-Bounded Organelle (GO:0043231) Lamellipodium (GO:0030027) Late Endosome Membrane (GO:0031902) Perinuclear Region Of Cytoplasm (GO:0048471) Synapse (GO:0045202) Vesicle (GO:0031982)

Biology & Function

Description
Function as phospholipase selectivefor phosphatidylcholine (PubMed:9395408). Implicated as a critical step in numerous cellular pathways, including signal transduction, membrane trafficking, and the regulation of mitosis. May be involved in the regulation of perinuclear intravesicular membrane traffic (PubMed:9395408). {Experimental EvidencePubMed:9395408}.
Assigned Ontology terms

Biological Process	Defense Response To Gram-Positive Bacterium (GO:0050830) Inositol Lipid-Mediated Signaling (GO:0048017) Phosphatidic Acid Biosynthetic Process (GO:0006654) Phospholipid Biosynthetic Process (GO:0008654) Phospholipid Catabolic Process (GO:0009395) Positive Regulation Of Cell Migration (GO:0030335) Positive Regulation Of Translation (GO:0045727) Regulation Of Microvillus Assembly (GO:0032534) Regulation Of Synaptic Vesicle Cycle (GO:0098693) Regulation Of Vesicle-Mediated Transport (GO:0060627) Response To Peptide Hormone (GO:0043434)
Molecular Function	N-Acylphosphatidylethanolamine-Specific Phospholipase D Activity (GO:0070290) Phosphatidylinositol Binding (GO:0035091) Phospholipase D Activity (GO:0004630)

Disease associations

Description
Note=Defects in Pld1 may result in coa which is associated with coat color dilution and white spotting. It is also associated with platelet-storage pool deficiency characterized by decreased levels in serotonin and dense granules.
Database Associations
OMIM
DisGeNET

Protein-Protein Interactions

Interactions with other proteins (1 interactors)

Partner (UniProt)		IntAct	Confidence score
P49769	Presenilin-1 (PS-1) (EC 3.4.23.-) (Protein S182) [Cleaved into: Presenilin-1 NTF subunit; Presenilin-1 CTF subunit; Presenilin-1 CTF12 (PS1-CTF12)]	EBI-15566353	0.40

Cross-References

Database	Links
UNIPROT	Q9Z280 O35911
Pfam	PF00169 PF00614 PF13091 PF00787
PROSITE	PS50003 PS50035 PS50195

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