NucEnvDB

NucEnvDB

A database of Nuclear Envelope Proteins and their Interactions

Adenylate cyclase type 10 - Rattus norvegicus - NucEnvDB

Adenylate cyclase type 10 (Rattus norvegicus)

FASTA TEXT XML

Subcellular Location Biology & Function Cross-References

General Information

Protein Information
Protein Name	Adenylate cyclase type 10
Accession Code	Q9Z286
Gene	Adcy10
Organism	Rattus norvegicus \| Norway rat (Taxonomy: 10116)
Part of Reference Proteome?	Yes
Sequence (Length: 1608)
MSARRQELQDRAIVKIAAHLPDLIVYGDFSPERPSVKCFDGVLMFVDISGFTAMTEKFSTAMYMDRGAEQLVEILNYYISAIVEKVLIFGGDILKFAGDALLALWKVERKQLKNIITVVIKCSLEIHGLF EAKEVEEGLDIRVKIGLAAGHITMLVFGDETRNYFLVIGQAVDDVRLAQNMAQMNDVILSPNCWQLCDRSMIEIERIPDQRAVKVSFLKPPPTFNFDEFFAKCMAFMDYYPSGDHKNFLRLACMLESDPE LELSLQKYVMEIILKQIDDKQLRGYLSELRPVTIVFVNLMFKEQDKAEVIGSAIQAACVHITSVLKVFRGQINKVFMFDKGCSFLCVFGFPGEKAPDEITHALESAVDIFDFCSQVHKIRTVSIGVASGI VFCGIVGHTVRHEYTVIGQKVNIAARMMMYYPGIVTCDSVTYDGSNLPAYFFKELPKKVMKGVADPGPVYQCLGLNEKVMFGMAYLICNRYEGYPLLGRVREIDYFMSTMKDFLMTNCSRVLMYEGLPGY GKSQVLMEIEYLASQHENHRAVAIALTKISFHQNFYTIQILMANVLGLDTCKHYKERQTNLQNRVKTLLDDKYHCLLNDIFHVQFPVSREMSRMSKIRKQKQLEALFMKILEQTVREERIIFIIDEAQFV DVASWAFIEKLIRSMPIFIVMSLCPFPETPCAAANAIMKNRNTTYITLGTMQPQEIRDKVCVDLSVSSIPRELDSYLVEGSCGIPYYCEELLKNLDHHRILIFQQAEAEEKTNVTWNNLFKYSVKPTEDM YLYTSIAAGQKEACYLTSGVRLKNLSPPASLKEISLVQLDSMSLSHQMLVRCAAIIGLTFTTELLFEILPCWNMKMMIKALATLVESNVFDCFRSSKDLQLALKQNVTTFEVHYRSLSLKSKEGLAYSEE EQLREMEGEVIECRILRFCRPIMQKTAYELWLKDQKKVLHLKCARFLEESAHRCNHCRNRDFIPYHHFIADIRLNTLDMDTVKKMVKSHGFKTEDEVIFSKSEIPRKFKFPENISITETREKILHFFDNV IIKMRTSQDDVIPLESCHCEELLQIVILPLAQHFVALEENNKALYYFLELASAYLILGDNYNAYMYLGEGERLLKSLTNEDSWSQTFEYATFYSLKGEICFNMGQMVLAKKMLRKALKLLNRMFPCNLLS LTFQMHIEKNRLSHFMNQHTQEGSLPGKKLAQLFLQSSCFSLLWKIYSLNFFFHYKYYGRLAAIMQMNTSLETQNNFQIIKAFLDFSLYRHLAGYEGVWFKYEILVMEQLLNLPLKGEAFEIMAYAADAL GHIKFLTGHLDLAIELGSRAHKMWSLLRNPNKYHMVLCRLSKPLFLKSRYKHLVQVLGWLWDLSVTEEHIFSKAFFYFVCLDIMLYSGFIYRTFEECLEFIHHNEDNRILKFQSGLLLGLYSCIAVWYAR LQEWDNFYKFSNRAKTLVTRRTPTVLYYEGISRYMEGQVLHLQKQIEEQAENAQDSGVELLKALETLVAQNTTGPVFYPRLYHLMAYVCILMGDGHSCDFFLNTALELSETQGNLLEKCWLSMSKEWWYS APELTGDQWLQTVLSLPSWDKIVSGNVTLQDVQKNKFLMRVNILDNPF

Subcellular Location

Description
Cell membrane {By SimilarityUniProtKB:Q96PN6}; Peripheral membrane protein {By SimilarityUniProtKB:Q96PN6}; Cytoplasmic side {By SimilarityUniProtKB:Q96PN6}. Cytoplasm, cytoskeleton {By SimilarityUniProtKB:Q96PN6}. Cytoplasm, perinuclear region {By SimilarityUniProtKB:Q96PN6}. Nucleus {ECO:0000269\|PubMed:12475901}. Cell projection, cilium {By SimilarityUniProtKB:Q96PN6}. Cytoplasm {ECO:0000269\|PubMed:9874775}. Mitochondrion {ECO:0000269\|PubMed:12475901}. Note=Distributed to subcellular compartments containing cAMP targets. Found as a plasma membrane- associated protein, protein concentrated in the perinuclear region and protein colocalized with actin or tubulin. {By SimilarityUniProtKB:Q96PN6}.
Position in the Nuclear Envelope
Location	Location ID	Description
Perinuclear Region	SL-0198	The perinuclear region is the cytoplasmic region just around the nucleus.
Membrane Topology
Topology	Source	Annotation Type
Peripheral	UniProt	By Similarity {ECO:0000250\|UniProtKB:Q96PN6}
Assigned Ontology terms

Cellular Component	Apical Part Of Cell (GO:0045177) Apical Plasma Membrane (GO:0016324) Axon (GO:0030424) Basal Part Of Cell (GO:0045178) Cytoplasm (GO:0005737) Cytosol (GO:0005829) Dendrite (GO:0030425) Extracellular Region (GO:0005576) Growth Cone (GO:0030426) Membrane (GO:0016020) Microtubule Cytoskeleton (GO:0015630) Mitochondrion (GO:0005739) Motile Cilium (GO:0031514) Neuronal Cell Body (GO:0043025) Nucleus (GO:0005634) Perinuclear Region Of Cytoplasm (GO:0048471)

Biology & Function

Description
Catalyzes the formation of the signaling molecule cAMP (PubMed:9874775). May function as sensor that mediates responses to changes in cellular bicarbonate and CO(2) levels (By similarity). Has a critical role in mammalian spermatogenesis by producing the cAMP which regulates cAMP-responsive nuclear factors indispensable for sperm maturation in the epididymis. Induces capacitation, the maturational process that sperm undergo prior to fertilization (By similarity). Involved in ciliary beat regulation (By similarity). {By SimilarityUniProtKB:Q8C0T9, By SimilarityUniProtKB:Q96PN6, Experimental EvidencePubMed:9874775}.
Assigned Ontology terms

Biological Process	CAMP Biosynthetic Process (GO:0006171) Cellular Response To Inorganic Substance (GO:0071241) Epithelial Cilium Movement Involved In Extracellular Fluid Movement (GO:0003351) Intracellular Signal Transduction (GO:0035556) Positive Regulation Of Apoptotic Process (GO:0043065) Spermatogenesis (GO:0007283)
Molecular Function	Adenylate Cyclase Activity (GO:0004016) ATP Binding (GO:0005524) ATPase Binding (GO:0051117) Bicarbonate Binding (GO:0071890) Magnesium Ion Binding (GO:0000287) Manganese Ion Binding (GO:0030145)

Cross-References

Database	Links
UNIPROT	Q9Z286
Pfam	PF00211
PROSITE	PS50125

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