The most exciting phrase to hear in science, the one that heralds the most discoveries, is not ‘Eureka’ but ‘That’s funny…’ “Nothing is a waste of time if we use the experience wisely”

Our laboratory is well equipped to facilitate bacterial protein expression and purification for any purpose. like bacullovirus or other eukaryotic homologous or heterologous protein overproduction system. In addition we are running molecular and cellular biology techniques and protein purification and characterization. We have fully functioning cell culture facilities.

Our group is a partner of the Athenian crystallization consortium and has direct access to X-ray facilities using normal generator and further on connections to synchrotron facilities at the European level.

Our group is in association with Biophysical facilities for protein thermodynamic studies at the Nuclear Research Center Demokritos, Athens and the Protein Structure Group at the Polish Academy of Science. In Germany there is a strong link with Ulm University, Heidelberg University as well as the Technical University Hamburg-Harburg and EMBL.

We are running several in house projects in close cooperation with various laboratories within Europe and we have been involved in several European Projects.

Our projects generally deal with Protein-Structure Function of bacterial and eukaryotic proteins. The projects are briefly the following:

1. Stucture-function and thermal stability studies on the DNA binding protein HU from various thermophilic-hyperthermophilic and psychrophilic bacteria.
2. Structure-function studies on chitinolytic enzymes from mesophilic-hyperthermophilic and psychrophilic enzymes
3. Structure-function studies on hyperthemophilic nitrilases
4. Structure-function studies of BRCA1 protein (a breast cancer marker gene)
5. Structure-function studies on the interaction between the human DNA repair factor Rad51 and the tumour suppressor protein p53.
6. Structure-function studies on kinases (LMKT3)
7. DNA repair in Cancer Stem Cells
8. Protein DNA interaction at single molecule level.

These projects involve all the modern techniques of biochemistry, molecular biology, structural biology and biophysics.