[Isoform 2]: Nucleus inner membrane {By
SimilarityUniProtKB:Q5SNT2}; Multi-pass membrane protein {By
SimilarityUniProtKB:Q5SNT2}. Note=The C-terminal of isoform 2 is located on the nucleoplasmic side. During interphase, isoform 2 is distributed in the inner nuclear membrane and during mitosis, it is found in the ER but it also localizes to the polar regions of the mitotic spindle (By similarity). {By
SimilarityUniProtKB:Q5SNT2}.
The nuclear envelope is a membrane system which surrounds the nucleoplasm of eukaryotic cells. It is composed of the nuclear lamina, nuclear pore complexes and two nuclear membranes. The space between the two membranes is called the nuclear intermembrane space.
The inner membrane of the nucleus is the membrane which separates the nuclear matrix from the intermembrane space. In mammals, the inner nuclear membrane is associated with heterochromatin and the nuclear lamina.
The membrane surrounding the nucleus. This term is used when it is not known if the protein is found in or associated with the inner or outer nuclear membrane.
Involved in nuclear movement during fibroblast polarization and migration (PubMed:22349700). May recruit Ran GTPase to the nuclear periphery (By similarity). {By
SimilarityUniProtKB:Q5SNT2, Experimental EvidencePubMed:22349700}. [Isoform 2]: May define a distinct membrane domain in the vicinity of the mitotic spindle. Involved in the organization of the nuclear envelope implicating EMD, SUN1 and A-type lamina. {By
SimilarityUniProtKB:Q5SNT2}. [Isoform 3]: Proposed to be involved in actin-dependent nuclear movement; via SUN2 associates with transmembrane actin- associated nuclear (TAN) lines which are bound to F-actin cables and couple the nucleus to retrograde actin flow. {ECO:0000305|PubMed:22349700}.
National and Kapodistrian University of Athens
Department of Biology
Biophysics & Bioinformatics Laboratory