National and Kapodistrian University of Athens
Department of Biology
Biophysics & Bioinformatics Laboratory
Protein Information |
|
|---|---|
| Protein Name | E1B protein, small T-antigen |
| Accession Code | P03247 |
| Gene | E1B |
| Organism | Human adenovirus 2 (Taxonomy: 10515) |
| Part of Reference Proteome? | Yes |
| Sequence (Length: 175) |
Description |
Position in the Nuclear Envelope |
|
|---|---|---|
| Location | Location ID | Description |
| Host Nuclear Envelope | SL-0415 | The host nuclear envelope is a membrane system which surrounds the host nucleoplasm of eukaryotic cells. It is composed of the nuclear lamina, nuclear pore complexes and two nuclear membranes. The space between the two membranes is called the host nuclear intermembrane space. Note: This location is defined for viral proteins that appear in the Nuclear Envelope of infected host cells |
| Host Nuclear Lamina | SL-0416 | The host nuclear lamina is a meshwork of intermediate filament proteins called lamins and lamin-binding proteins that are embedded in the host inner nuclear membrane. Note: This location is defined for viral proteins that appear in the nuclear lamina of infected host cells | Membrane Topology |
| Topology | Source | Annotation Type |
| Unknown | UniProt | Sequence Analysis | Assigned Ontology terms |
Description |
|
|---|---|
| Putative adenovirus Bcl-2 homolog that inhibits apoptosis induced by TNF or FAS pathways, as well as p53-mediated apoptosis. Without E1B 19K function, virus production is compromised because of premature death of host cell. Interacts with Bax protein in cell lysates (By similarity). {By Similarity}. | Assigned Ontology terms |
Interactions with Nuclear Envelope proteins (3 interactors) |
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|---|---|---|---|
Interactions with other proteins (2 interactors) |
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National and Kapodistrian University of Athens
Department of Biology
Biophysics & Bioinformatics Laboratory