Nucleoside diphosphate kinase B - Homo sapiens

Nucleoside diphosphate kinase B (Homo sapiens)

FASTA TEXT XML

Subcellular Location Biology & Function Interactions Cross-References

General Information

Protein Information
Protein Name	Nucleoside diphosphate kinase B
Accession Code	P22392
Gene	NME2
Organism	Homo sapiens \| Human (Taxonomy: 9606)
Part of Reference Proteome?	Yes
Sequence (Length: 152)
MANLERTFIAIKPDGVQRGLVGEIIKRFEQKGFRLVAMKFLRASEEHLKQHYIDLKDRPFFPGLVKYMNSGPVVAMVWEG LNVVKTGRVMLGETNPADSKPGTIRGDFCIQVGRNIIHGSDSVKSAEKEISLWFKPEELVDYKSCAHDWVYE

Structure Viewer (PDB: 1NSK)

Subcellular Location

Description
Cytoplasm {Experimental EvidencePubMed:17532299}. Cell projection, lamellipodium {Experimental EvidencePubMed:11919189}. Cell projection, ruffle {Experimental EvidencePubMed:11919189}. Note=Colocalizes with ITGB1 and ITGB1BP1 at the edge or peripheral ruffles and lamellipodia during the early stages of cell spreading on fibronectin or collagen but not on vitronectin or laminin substrates. {Experimental EvidencePubMed:11919189}. [Isoform 1]: Cytoplasm {ECO:0000269\|PubMed:16442775}. Cytoplasm, perinuclear region {ECO:0000269\|PubMed:16442775}. Nucleus {ECO:0000269\|PubMed:16442775}. [Isoform 3]: Cytoplasm {ECO:0000269\|PubMed:16442775}. Cytoplasm, perinuclear region {ECO:0000269\|PubMed:16442775}. Nucleus {ECO:0000269\|PubMed:16442775}.
Position in the Nuclear Envelope
Location	Location ID	Description
Perinuclear Region	SL-0198	The perinuclear region is the cytoplasmic region just around the nucleus.
Membrane Topology
Topology	Source	Annotation Type
Unknown	UniProt	Sequence Analysis
Assigned Ontology terms

Cellular Component	Cell Periphery (GO:0071944) Cytoplasm (GO:0005737) Cytosol (GO:0005829) Extracellular Exosome (GO:0070062) Extracellular Region (GO:0005576) Ficolin-1-Rich Granule Lumen (GO:1904813) Lamellipodium (GO:0030027) Nucleus (GO:0005634) Perinuclear Region Of Cytoplasm (GO:0048471) Ruffle (GO:0001726) Secretory Granule Lumen (GO:0034774)

Biology & Function

Description
Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity). Negatively regulates Rho activity by interacting with AKAP13/LBC (PubMed:15249197). Acts as a transcriptional activator of the MYC gene; binds DNA non-specifically (PubMed:8392752, PubMed:19435876). Binds to both single-stranded guanine- and cytosine-rich strands within the nuclease hypersensitive element (NHE) III(1) region of the MYC gene promoter. Does not bind to duplex NHE III(1) (PubMed:19435876). Has G-quadruplex (G4) DNA-binding activity, which is independent of its nucleotide-binding and kinase activity. Binds both folded and unfolded G4 with similar low nanomolar affinities. Stabilizes folded G4s regardless of whether they are prefolded or not (PubMed:25679041). Exhibits histidine protein kinase activity (PubMed:20946858). {By SimilarityUniProtKB:P36010, Experimental EvidencePubMed:15249197, Experimental EvidencePubMed:19435876, Experimental EvidencePubMed:20946858, Experimental EvidencePubMed:25679041, Experimental EvidencePubMed:8392752}.
Assigned Ontology terms

Biological Process	Cell Adhesion (GO:0007155) CTP Biosynthetic Process (GO:0006241) GTP Biosynthetic Process (GO:0006183) Integrin-Mediated Signaling Pathway (GO:0007229) Negative Regulation Of Apoptotic Process (GO:0043066) Nucleoside Diphosphate Phosphorylation (GO:0006165) Nucleoside Triphosphate Biosynthetic Process (GO:0009142) Positive Regulation Of DNA-Templated Transcription (GO:0045893) Positive Regulation Of Epithelial Cell Proliferation (GO:0050679) Positive Regulation Of Keratinocyte Differentiation (GO:0045618) Positive Regulation Of Transcription By RNA Polymerase II (GO:0045944) Regulation Of Apoptotic Process (GO:0042981) Regulation Of Epidermis Development (GO:0045682) UTP Biosynthetic Process (GO:0006228)
Molecular Function	ATP Binding (GO:0005524) DNA Binding (GO:0003677) G-Quadruplex DNA Binding (GO:0051880) GDP Binding (GO:0019003) Metal Ion Binding (GO:0046872) Nucleoside Diphosphate Kinase Activity (GO:0004550) Protein Histidine Kinase Activity (GO:0004673) Transcription Coactivator Activity (GO:0003713)

Protein-Protein Interactions

Interactions with Nuclear Envelope proteins (2 interactors)

Partner (NucEnvDB)		IntAct	Confidence score
P22392	Self	EBI-3943380	0.37
Q00613	Heat shock factor protein 1	EBI-9394221	0.35
Interactions with other proteins (95 interactors)

Partner (UniProt)		IntAct	Confidence score
Q13232	Nucleoside diphosphate kinase 3 (NDK 3) (NDP kinase 3) (EC 2.7.4.6) (DR-nm23) (Nucleoside diphosphate kinase C) (NDPKC) (nm23-H3)	EBI-21647179	0.35
Q15435	Protein phosphatase 1 regulatory subunit 7 (Protein phosphatase 1 regulatory subunit 22)	EBI-1059661	0.00
P01615	Immunoglobulin kappa variable 2D-28 (Ig kappa chain V-II region FR) (Ig kappa chain V-II region GM607) (Ig kappa chain V-II region MIL) (Ig kappa chain V-II region TEW)	EBI-1061143	0.00
P28222	5-hydroxytryptamine receptor 1B (5-HT-1B) (5-HT1B) (S12) (Serotonin 1D beta receptor) (5-HT-1D-beta) (Serotonin receptor 1B)	EBI-1061406	0.00
Q12972	Nuclear inhibitor of protein phosphatase 1 (NIPP-1) (Protein phosphatase 1 regulatory inhibitor subunit 8) [Includes: Activator of RNA decay (EC 3.1.4.-) (ARD-1)]	EBI-1064323	0.00
P52434	DNA-directed RNA polymerases I, II, and III subunit RPABC3 (RNA polymerases I, II, and III subunit ABC3) (DNA-directed RNA polymerase II subunit H) (DNA-directed RNA polymerases I, II, and III 17.1 kDa polypeptide) (RPB17) (RPB8 homolog) (hRPB8)	EBI-1071336	0.00
P62807	Histone H2B type 1-C/E/F/G/I (Histone H2B.1 A) (Histone H2B.a) (H2B/a) (Histone H2B.g) (H2B/g) (Histone H2B.h) (H2B/h) (Histone H2B.k) (H2B/k) (Histone H2B.l) (H2B/l)	EBI-1075233	0.00
Q9HB71	Calcyclin-binding protein (CacyBP) (hCacyBP) (S100A6-binding protein) (Siah-interacting protein)	EBI-1075281	0.00
O00264	Membrane-associated progesterone receptor component 1 (mPR) (Dap1) (IZA)	EBI-1075521	0.00
P63173	60S ribosomal protein L38 (Large ribosomal subunit protein eL38)	EBI-1075834	0.00
P54819	Adenylate kinase 2, mitochondrial (AK 2) (EC 2.7.4.3) (ATP-AMP transphosphorylase 2) (ATP:AMP phosphotransferase) (Adenylate monophosphate kinase) [Cleaved into: Adenylate kinase 2, mitochondrial, N-terminally processed]	EBI-1076537	0.00
P61088	Ubiquitin-conjugating enzyme E2 N (EC 2.3.2.23) (Bendless-like ubiquitin-conjugating enzyme) (E2 ubiquitin-conjugating enzyme N) (Ubc13) (UbcH13) (Ubiquitin carrier protein N) (Ubiquitin-protein ligase N)	EBI-1076851	0.00
Q9NPH2	Inositol-3-phosphate synthase 1 (IPS 1) (EC 5.5.1.4) (Myo-inositol 1-phosphate synthase) (MI-1-P synthase) (MIP synthase) (hIPS) (Myo-inositol 1-phosphate synthase A1) (hINO1)	EBI-1076944	0.00
Q13283	Ras GTPase-activating protein-binding protein 1 (G3BP-1) (EC 3.6.4.12) (EC 3.6.4.13) (ATP-dependent DNA helicase VIII) (hDH VIII) (GAP SH3 domain-binding protein 1)	EBI-1076964	0.00
Q01105	Protein SET (HLA-DR-associated protein II) (Inhibitor of granzyme A-activated DNase) (IGAAD) (PHAPII) (Phosphatase 2A inhibitor I2PP2A) (I-2PP2A) (Template-activating factor I) (TAF-I)	EBI-1077547	0.00
P25787	Proteasome subunit alpha type-2 (Macropain subunit C3) (Multicatalytic endopeptidase complex subunit C3) (Proteasome component C3)	EBI-1077873	0.00
Q9Y3F4	Serine-threonine kinase receptor-associated protein (MAP activator with WD repeats) (UNR-interacting protein) (WD-40 repeat protein PT-WD)	EBI-1077889	0.00
P61086	Ubiquitin-conjugating enzyme E2 K (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme K) (Huntingtin-interacting protein 2) (HIP-2) (Ubiquitin carrier protein) (Ubiquitin-conjugating enzyme E2-25 kDa) (Ubiquitin-conjugating enzyme E2(25K)) (Ubiquitin-conjugating enzyme E2-25K) (Ubiquitin-protein ligase)	EBI-1077953	0.00
P16152	Carbonyl reductase [NADPH] 1 (EC 1.1.1.184) (15-hydroxyprostaglandin dehydrogenase [NADP(+)]) (EC 1.1.1.196, EC 1.1.1.197) (20-beta-hydroxysteroid dehydrogenase) (Alcohol dehydrogenase [NAD(P)+] CBR1) (EC 1.1.1.71) (NADPH-dependent carbonyl reductase 1) (Prostaglandin 9-ketoreductase) (PG-9-KR) (Prostaglandin-E(2) 9-reductase) (EC 1.1.1.189) (Short chain dehydrogenase/reductase family 21C member 1)	EBI-1078617	0.00
P61626	Lysozyme C (EC 3.2.1.17) (1,4-beta-N-acetylmuramidase C)	EBI-1078976	0.00
P39019	40S ribosomal protein S19 (Small ribosomal subunit protein eS19)	EBI-1078996	0.00
Q15084	Protein disulfide-isomerase A6 (EC 5.3.4.1) (Endoplasmic reticulum protein 5) (ER protein 5) (ERp5) (Protein disulfide isomerase P5) (Thioredoxin domain-containing protein 7)	EBI-1079212	0.00
P62249	40S ribosomal protein S16 (Small ribosomal subunit protein uS9)	EBI-1079501	0.00
O00232	26S proteasome non-ATPase regulatory subunit 12 (26S proteasome regulatory subunit RPN5) (26S proteasome regulatory subunit p55)	EBI-1079589	0.00
P05455	Lupus La protein (La autoantigen) (La ribonucleoprotein) (Sjoegren syndrome type B antigen) (SS-B)	EBI-1080231	0.00
Q9NQC3	Reticulon-4 (Foocen) (Neurite outgrowth inhibitor) (Nogo protein) (Neuroendocrine-specific protein) (NSP) (Neuroendocrine-specific protein C homolog) (RTN-x) (Reticulon-5)	EBI-1080716	0.00
P30153	Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform (Medium tumor antigen-associated 61 kDa protein) (PP2A subunit A isoform PR65-alpha) (PP2A subunit A isoform R1-alpha)	EBI-1080986	0.00
Q15365	Poly(rC)-binding protein 1 (Alpha-CP1) (Heterogeneous nuclear ribonucleoprotein E1) (hnRNP E1) (Nucleic acid-binding protein SUB2.3)	EBI-1081301	0.00
P04844	Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 (Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 63 kDa subunit) (RIBIIR) (Ribophorin II) (RPN-II) (Ribophorin-2)	EBI-1082016	0.00
P58107	Epiplakin (450 kDa epidermal antigen)	EBI-1082068	0.00
P53396	ATP-citrate synthase (EC 2.3.3.8) (ATP-citrate (pro-S-)-lyase) (ACL) (Citrate cleavage enzyme)	EBI-1082405	0.00
O60518	Ran-binding protein 6 (RanBP6)	EBI-1082514	0.00
Q9Y333	U6 snRNA-associated Sm-like protein LSm2 (Protein G7b) (Small nuclear ribonuclear protein D homolog) (snRNP core Sm-like protein Sm-x5)	EBI-1082666	0.00
P61326	Protein mago nashi homolog	EBI-1082762	0.00
Q9Y2L1	Exosome complex exonuclease RRP44 (EC 3.1.13.-) (EC 3.1.26.-) (Protein DIS3 homolog) (Ribosomal RNA-processing protein 44)	EBI-1083038	0.00
P31948	Stress-induced-phosphoprotein 1 (STI1) (Hsc70/Hsp90-organizing protein) (Hop) (Renal carcinoma antigen NY-REN-11) (Transformation-sensitive protein IEF SSP 3521)	EBI-1083082	0.00
Q6FHQ0	RBBP7 protein (Retinoblastoma binding protein 7) (Retinoblastoma binding protein 7, isoform CRA_a)	EBI-1083767	0.00
P54725	UV excision repair protein RAD23 homolog A (HR23A) (hHR23A)	EBI-1084508	0.00
O14818	Proteasome subunit alpha type-7 (Proteasome subunit RC6-1) (Proteasome subunit XAPC7)	EBI-1084536	0.00
P50502	Hsc70-interacting protein (Hip) (Aging-associated protein 2) (Progesterone receptor-associated p48 protein) (Protein FAM10A1) (Putative tumor suppressor ST13) (Renal carcinoma antigen NY-REN-33) (Suppression of tumorigenicity 13 protein)	EBI-1084657	0.00
P68402	Platelet-activating factor acetylhydrolase IB subunit alpha2 (EC 3.1.1.47) (PAF acetylhydrolase 30 kDa subunit) (PAF-AH 30 kDa subunit) (PAF-AH subunit beta) (PAFAH subunit beta)	EBI-1084933	0.00
Q14204	Cytoplasmic dynein 1 heavy chain 1 (Cytoplasmic dynein heavy chain 1) (Dynein heavy chain, cytosolic)	EBI-1085083	0.00
P28070	Proteasome subunit beta type-4 (26 kDa prosomal protein) (HsBPROS26) (PROS-26) (Macropain beta chain) (Multicatalytic endopeptidase complex beta chain) (Proteasome beta chain) (Proteasome chain 3) (HsN3)	EBI-1085900	0.00
Q9NZ23	Drug-sensitive protein 1 (Gastric-associated differentially-expressed protein YA61P)	EBI-1085916	0.00
Q9Y230	RuvB-like 2 (EC 3.6.4.12) (48 kDa TATA box-binding protein-interacting protein) (48 kDa TBP-interacting protein) (51 kDa erythrocyte cytosolic protein) (ECP-51) (INO80 complex subunit J) (Repressing pontin 52) (Reptin 52) (TIP49b) (TIP60-associated protein 54-beta) (TAP54-beta)	EBI-1086002	0.00
Q7L2H7	Eukaryotic translation initiation factor 3 subunit M (eIF3m) (Fetal lung protein B5) (hFL-B5) (PCI domain-containing protein 1)	EBI-1086018	0.00
P31939	Bifunctional purine biosynthesis protein ATIC (AICAR transformylase/inosine monophosphate cyclohydrolase) (ATIC) [Cleaved into: Bifunctional purine biosynthesis protein ATIC, N-terminally processed] [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC 2.1.2.3) (5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase) (AICAR formyltransferase) (AICAR transformylase); Inosine 5'-monophosphate cyclohydrolase (IMP cyclohydrolase) (EC 3.5.4.10) (IMP synthase) (Inosinicase)]	EBI-1086191	0.00
P33176	Kinesin-1 heavy chain (Conventional kinesin heavy chain) (Ubiquitous kinesin heavy chain) (UKHC)	EBI-1086252	0.00
P63104	14-3-3 protein zeta/delta (Protein kinase C inhibitor protein 1) (KCIP-1)	EBI-7192531	0.40
Q00005	Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform (PP2A subunit B isoform B55-beta) (PP2A subunit B isoform PR55-beta) (PP2A subunit B isoform R2-beta) (PP2A subunit B isoform beta)	EBI-2210942	0.35
O14713	Integrin beta-1-binding protein 1 (Integrin cytoplasmic domain-associated protein 1) (ICAP-1)	EBI-2127350	0.67
P15531	Nucleoside diphosphate kinase A (NDK A) (NDP kinase A) (EC 2.7.4.6) (Granzyme A-activated DNase) (GAAD) (Metastasis inhibition factor nm23) (NM23-H1) (Tumor metastatic process-associated protein)	EBI-2127719	0.68
P62745	Rho-related GTP-binding protein RhoB (Rho cDNA clone 6) (h6)	EBI-2505928	0.37
P68372	Tubulin beta-4B chain (Tubulin beta-2C chain)	EBI-2562208	0.40
O46385	Supervillin (Archvillin) (p205/p250)	EBI-7872718	0.37
A0A380PGZ4	Putative exported protein	EBI-2863406	0.00
Q8ZJJ5	ATP-dependent protease ATPase subunit HslU (Unfoldase HslU)	EBI-2863413	0.00
Q13363	C-terminal-binding protein 1 (CtBP1) (EC 1.1.1.-)	EBI-3907897	0.37
P20339	Ras-related protein Rab-5A (EC 3.6.5.2)	EBI-3911907	0.37
Q14161	ARF GTPase-activating protein GIT2 (ARF GAP GIT2) (Cool-interacting tyrosine-phosphorylated protein 2) (CAT-2) (CAT2) (G protein-coupled receptor kinase-interactor 2) (GRK-interacting protein 2)	EBI-3932667	0.37
O00746	Nucleoside diphosphate kinase, mitochondrial (NDK) (NDP kinase, mitochondrial) (EC 2.7.4.6) (Nucleoside diphosphate kinase D) (NDPKD) (nm23-H4)	EBI-3932657	0.55
Q7Z465	Bcl-2/adenovirus E1B 19 kDa-interacting protein 2-like protein	EBI-3942659	0.37
Q8IZL9	Cyclin-dependent kinase 20 (EC 2.7.11.22) (CDK-activating kinase p42) (CAK-kinase p42) (Cell cycle-related kinase) (Cell division protein kinase 20) (Cyclin-dependent protein kinase H) (Cyclin-kinase-activating kinase p42)	EBI-6381092	0.35
Q9Y2J4	Angiomotin-like protein 2 (Leman coiled-coil protein) (LCCP)	EBI-8797381	0.35
Q96FW1	Ubiquitin thioesterase OTUB1 (EC 3.4.19.12) (Deubiquitinating enzyme OTUB1) (OTU domain-containing ubiquitin aldehyde-binding protein 1) (Otubain-1) (hOTU1) (Ubiquitin-specific-processing protease OTUB1)	EBI-10770198	0.35
Q71U36	Tubulin alpha-1A chain (EC 3.6.5.-) (Alpha-tubulin 3) (Tubulin B-alpha-1) (Tubulin alpha-3 chain) [Cleaved into: Detyrosinated tubulin alpha-1A chain]	EBI-11897791	0.35
Q8NI37	Protein phosphatase PTC7 homolog (EC 3.1.3.16) (T-cell activation protein phosphatase 2C) (TA-PP2C) (T-cell activation protein phosphatase 2C-like)	EBI-14026943	0.35
Q8TCT1	Phosphoethanolamine/phosphocholine phosphatase (EC 3.1.3.75)	EBI-14027014	0.35
Q9H3S7	Tyrosine-protein phosphatase non-receptor type 23 (EC 3.1.3.48) (His domain-containing protein tyrosine phosphatase) (HD-PTP) (Protein tyrosine phosphatase TD14) (PTP-TD14)	EBI-14027652	0.35
Q76RH1	Cytoplasmic envelopment protein 1	EBI-14063481	0.40
P50570	Dynamin-2 (EC 3.6.5.5)	EBI-16110780	0.52
P62753	40S ribosomal protein S6 (Phosphoprotein NP33) (Small ribosomal subunit protein eS6)	EBI-16799122	0.35
Q96HJ9	Protein FMC1 homolog (ATP synthase assembly factor FMC1, mitochondrial) (Formation of mitochondrial complex V assembly factor 1 homolog)	EBI-21929593	0.35
O00483	Cytochrome c oxidase subunit NDUFA4 (Complex I-MLRQ) (CI-MLRQ) (NADH-ubiquinone oxidoreductase MLRQ subunit)	EBI-21930681	0.35
O75489	NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial (EC 7.1.1.2) (Complex I-30kD) (CI-30kD) (NADH-ubiquinone oxidoreductase 30 kDa subunit)	EBI-21931040	0.35
Q96FC7	Phytanoyl-CoA hydroxylase-interacting protein-like	EBI-21931532	0.35
Q8N3J5	Protein phosphatase 1K, mitochondrial (EC 3.1.3.16) (PP2C domain-containing protein phosphatase 1K) (PP2C-like mitochondrial protein) (PP2C-type mitochondrial phosphoprotein phosphatase) (PTMP) (Protein phosphatase 2C isoform kappa) (PP2C-kappa)	EBI-21931555	0.35
Q9H6K4	Optic atrophy 3 protein	EBI-21931410	0.35
Q9Y3B1	PRELI domain containing protein 3B (Protein slowmo homolog 2)	EBI-21931754	0.35
O60260	E3 ubiquitin-protein ligase parkin (Parkin) (EC 2.3.2.31) (Parkin RBR E3 ubiquitin-protein ligase) (Parkinson juvenile disease protein 2) (Parkinson disease protein 2)	EBI-21135687	0.35
P03372	Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1)	EBI-21301141	0.35
Q32Q12	Nucleoside diphosphate kinase (EC 2.7.4.6)	EBI-25382283	0.35
Q8N264	Rho GTPase-activating protein 24 (Filamin-A-associated RhoGAP) (FilGAP) (RAC1- and CDC42-specific GTPase-activating protein of 72 kDa) (RC-GAP72) (Rho-type GTPase-activating protein 24) (RhoGAP of 73 kDa) (Sarcoma antigen NY-SAR-88) (p73RhoGAP)	EBI-25408352	0.35
Q9NRY4	Rho GTPase-activating protein 35 (Glucocorticoid receptor DNA-binding factor 1) (Glucocorticoid receptor repression factor 1) (GRF-1) (Rho GAP p190A) (p190-A)	EBI-25408519	0.35
Q8NF50	Dedicator of cytokinesis protein 8	EBI-25409278	0.35
Q8K337	Type II inositol 1,4,5-trisphosphate 5-phosphatase (EC 3.1.3.36) (Inositol polyphosphate-5-phosphatase B) (Phosphoinositide 5-phosphatase) (5PTase)	EBI-25409748	0.35
Q8TCU6	Phosphatidylinositol 3,4,5-trisphosphate-dependent Rac exchanger 1 protein (P-Rex1) (PtdIns(3,4,5)-dependent Rac exchanger 1)	EBI-25411141	0.35
Q9H3R0	Lysine-specific demethylase 4C (EC 1.14.11.66) (Gene amplified in squamous cell carcinoma 1 protein) (GASC-1 protein) (JmjC domain-containing histone demethylation protein 3C) (Jumonji domain-containing protein 2C) ([histone H3]-trimethyl-L-lysine(9) demethylase 4C)	EBI-25479978	0.35
P51114	RNA-binding protein FXR1 (FMR1 autosomal homolog 1) (hFXR1p)	EBI-26510919	0.37
O60303	Katanin-interacting protein	EBI-26582514	0.35
P36507	Dual specificity mitogen-activated protein kinase kinase 2 (MAP kinase kinase 2) (MAPKK 2) (EC 2.7.12.2) (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK 2)	EBI-28935019	0.35
P0DTC9	Nucleoprotein (N) (Nucleocapsid protein) (NC) (Protein N)	EBI-28955760	0.35
Q9BXK1	Krueppel-like factor 16 (Basic transcription element-binding protein 4) (BTE-binding protein 4) (Novel Sp1-like zinc finger transcription factor 2) (Transcription factor BTEB4) (Transcription factor NSLP2)	EBI-29019783	0.35
Q05DH4	FHF complex subunit HOOK interacting protein 1A (FHIP1A) (FTS and Hook-interacting protein like) (FHIP-L)	EBI-34574576	0.27
Q5W0V3	FHF complex subunit HOOK interacting protein 2A (FHIP2A)	EBI-34574999	0.27

Cross-References

Database	Links
UNIPROT	P22392 A8MWA3 Q1WM23 Q6LCT6
PDB	1NSK 1NUE 3BBB 3BBC 3BBF 7KPF
Pfam	PF00334
PROSITE	PS00469
OMIM	156491
DisGeNET	4831 654364

Nucleoside diphosphate kinase B (Homo sapiens)

General Information

Protein Information

Structure Viewer (PDB: 1NSK)

Subcellular Location

Description Show

Position in the Nuclear Envelope

Membrane Topology

Assigned Ontology terms

Biology & Function

Description Hide

Assigned Ontology terms

Protein-Protein Interactions

Interactions with Nuclear Envelope proteins (2 interactors)

Interactions with other proteins (95 interactors)

Cross-References

Database

Links

Description

Description