NucEnvDB

NucEnvDB

A database of Nuclear Envelope Proteins and their Interactions

Kinesin-like protein KIF1A - Mus musculus - NucEnvDB

Kinesin-like protein KIF1A (Mus musculus)

FASTA TEXT XML

Subcellular Location Biology & Function Interactions Cross-References

General Information

Protein Information
Protein Name	Kinesin-like protein KIF1A
Accession Code	P33173
Gene	Kif1a
Organism	Mus musculus \| House mouse (Taxonomy: 10090)
Part of Reference Proteome?	Yes
Sequence (Length: 1695)
MAGASVKVAVRVRPFNSREMSRDSKCIIQMSGSTTTIVNPKQPKETPKSFSFDYSYWSHTSPEDINYASQKQVYRDIGEE MLQHAFEGYNVCIFAYGQTGAGKSYTMMGKQEKDQQGIIPQLCEDLFSRINDTTNDNMSYSVEVSYMEIYCERVRDLLNP KNKGNLRVREHPLLGPYVEDLSKLAVTSYNDIQDLMDSGNKPRTVAATNMNETSSRSHAVFNIIFTQKRHDAETNITTEK VSKISLVDLAGSERADSTGAKGTRLKEGANINKSLTTLGKVISALAEMDSGPNKNKKKKKTDFIPYRDSVLTWLLRENLG GNSRTAMVAALSPADINYDETLSTLRYADRAKQIRCNAIINEDPNNKLIRELKDEVTRLRDLLYAQGLGDITDMTNALVG MSPSSSLSALSSRAASVSSLHERILFAPGSEEAIERLKETEKIIAELNETWEEKLRRTEAIRMEREALLAEMGVAMREDG GTLGVFSPKKTPHLVNLNEDPLMSECLLYYIKDGVTRVGREDAERRQDIVLSGHFIKEEHCIFRSDSRGGGEAVVTLEPC EGADTYVNGKKVTEPSILRSGNRIIMGKSHVFRFNHPEQARQERERTPCAETPAEPVDWAFAQRELLEKQGIDMKQEMEQ RLQELEDQYRREREEATYLLEQQRLDYESKLEALQKQMDSRYYPEVNEEEEEPEDEVQWTERECELALWAFRKWKWYQFT SLRDLLWGNAIFLKEANAISVELKKKVQFQFVLLTDTLYSPLPPDLLPPEAAKDRETRPFPRTIVAVEVQDQKNGATHYW TLEKLRQRLDLMREMYDRAAEVPSSVVEDCDNVVTGGDPFYDRFPWFRLVGRAFVYLSNLLYPVPLVHRVAIVSEKGEVK GFLRVAVQAISADEEAPDYGSGVRQSGTAKISFDDQHFEKFQSESCPVVGMSRSGTSQEELRIVEGQGQGADAGPSADEV NNNTCSAVPPEGLMDSPEKAALDGPLDTALDHLRLGSTFTFRVTVLQASSISAEYADIFCQFNFIHRHDEAFSTEPLKNT GRGPPLGFYHVQNIAVEVTKSFIEYIKSQPIVFEVFGHYQQHPFPPLCKDVLSPLRPSRRHFPRVMPLSKPVPATKLSTM TRPSPGPCHCKYDLLVYFEICELEANGDYIPAVVDHRGACMGTFLLHQGIQRRITVTLLHETGSHIRWKEVRELVVGRIR NTPETDEALIDPNILSLNILSSGYVHPAQDDRVFFGNDTRTFYQFEAAWDSSMHNSLLLNRVTPYREKIYMTLSAYIEME NCTQPAVITKDFCMVFYSRDAKLPASRSIRNLFGSGSLRATEGNRVTGVYELSLCHVADAGSPGMQRRRRRVLDTSVAYV RGEENLAGWRPRSDSLILDHQWELEKLSLLQEVEKTRHYLLLREKLETTQRPGPEVLSPASSEDSESRSSSGASSPLSAE GQPSPLEAPNERQRELAVKCLRLLMHTFNREYTHSHVCISASESKLSEMSVTLMRDPSMSPLGAATLTPSSTCPSLIEGR YGATDVRTPQPCSRPASPEPELLPELDSKKTPSPVRATETEKEPQRLLVPDIQEIRVSPIVSKKGYLHFLEPHTAGWAKR FVVVRRPYAYMYNSDKDTVERFVLNLSTAQVEYSEDQQAMLKTPNTFAVCTEHRGILLQANSDKDMHDWLYAFNPLLAGT IRSKLSRRRSAQMRV

Structure Viewer (PDB: 1I5S)

Subcellular Location

Description
Cytoplasm, cytoskeleton {By SimilarityUniProtKB:Q12756}. Cell projection, axon {Experimental EvidencePubMed:7539720}. Cytoplasm, perinuclear region {Experimental EvidencePubMed:7539720}. Synapse. Cell projection, neuron projection {By SimilarityUniProtKB:Q12756}. Cytoplasmic vesicle, secretory vesicle, neuronal dense core vesicle membrane {ECO:0000250\|UniProtKB:F1M4A4}; Peripheral membrane protein {ECO:0000250\|UniProtKB:F1M4A4}; Cytoplasmic side {ECO:0000250\|UniProtKB:F1M4A4}. Note=Within neuronal cells concentrated in the axon, with smaller amounts in the perinuclear and synaptic regions (PubMed:7539720). Expressed in distal regions of neurites. {By SimilarityUniProtKB:Q12756, Experimental EvidencePubMed:7539720}.
Position in the Nuclear Envelope
Location	Location ID	Description
Perinuclear Region	SL-0198	The perinuclear region is the cytoplasmic region just around the nucleus.
Membrane Topology
Topology	Source	Annotation Type
Peripheral	UniProt	By Similarity {ECO:0000250\|UniProtKB:F1M4A4}
Assigned Ontology terms

Cellular Component	Anchoring Junction (GO:0070161) Axon (GO:0030424) Axon Cytoplasm (GO:1904115) Cytosol (GO:0005829) Dendrite (GO:0030425) Extrinsic Component Of Neuronal Dense Core Vesicle Membrane (GO:0098674) Kinesin Complex (GO:0005871) Microtubule (GO:0005874) Neuron Projection (GO:0043005) Neuronal Cell Body (GO:0043025) Neuronal Dense Core Vesicle (GO:0098992) Perinuclear Region Of Cytoplasm (GO:0048471) Postsynapse (GO:0098794) Presynapse (GO:0098793) Protein-Containing Complex (GO:0032991) Synaptic Vesicle (GO:0008021)

Biology & Function

Description
Motor for anterograde axonal transport of synaptic vesicle precursors (Probable). Also required for neuronal dense core vesicles (DCVs) transport to the dendritic spines and axons. The interaction calcium-dependent with CALM1 increases vesicle motility and interaction with the scaffolding proteins PPFIA2 and TANC2 recruits DCVs to synaptic sites (By similarity). {By SimilarityUniProtKB:F1M4A4, Curator Inference}.
Assigned Ontology terms

Biological Process	Anterograde Axonal Transport (GO:0008089) Anterograde Neuronal Dense Core Vesicle Transport (GO:1990048) Cytoskeleton-Dependent Intracellular Transport (GO:0030705) Dense Core Granule Cytoskeletal Transport (GO:0099519) Interkinetic Nuclear Migration (GO:0022027) Microtubule-Based Movement (GO:0007018) Protein Transport Along Microtubule (GO:0098840) Regulation Of Dendritic Spine Development (GO:0060998) Regulation Of Dendritic Spine Morphogenesis (GO:0061001) Retrograde Neuronal Dense Core Vesicle Transport (GO:1990049) Vesicle-Mediated Transport (GO:0016192)
Molecular Function	ATP Binding (GO:0005524) ATP Hydrolysis Activity (GO:0016887) Identical Protein Binding (GO:0042802) Microtubule Binding (GO:0008017) Microtubule Motor Activity (GO:0003777) Plus-End-Directed Microtubule Motor Activity (GO:0008574)

Protein-Protein Interactions

Interactions with Nuclear Envelope proteins (1 interactors)

Partner (NucEnvDB)		IntAct	Confidence score
P33173	Self	EBI-16002374	0.40
Interactions with other proteins (2 interactors)

Partner (UniProt)		IntAct	Confidence score
Q06335	Amyloid beta precursor like protein 2 (Amyloid beta (A4) precursor-like protein 2) (Amyloid protein homolog) (Amyloid-like protein 2) (APLP-2) (CDEI box-binding protein) (CDEBP) (Sperm membrane protein YWK-II)	EBI-2013377	0.40
Q6NZM9	Histone deacetylase 4 (HD4) (EC 3.5.1.98)	EBI-26472902	0.35

Cross-References

Database	Links
UNIPROT	P33173 Q61770
PDB	1I5S 1I6I 1IA0 1VFV 1VFW 1VFX 1VFZ 2HXF 2HXH 2ZFI 2ZFJ 2ZFK 2ZFL 2ZFM 7EO9 7EOB
Pfam	PF12473 PF00498 PF12423 PF00225 PF16183 PF00169
PROSITE	PS50006 PS00411 PS50067 PS50003

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