The nuclear envelope is a membrane system which surrounds the nucleoplasm of eukaryotic cells. It is composed of the nuclear lamina, nuclear pore complexes and two nuclear membranes. The space between the two membranes is called the nuclear intermembrane space.
The membrane surrounding the nucleus. This term is used when it is not known if the protein is found in or associated with the inner or outer nuclear membrane.
The outer membrane of the nucleus is the membrane facing the cytoplasm. In mammals, the outer nuclear membrane is continuous in many places with the rough endoplasmic reticulum and is dotted with ribosomes.
Lipid transport protein (LTP) involved in non-vesicular transfer of lipids between membranes. Functions in phosphoinositide- coupled directional transport of various lipids by carrying the lipid molecule in a hydrophobic pocket and transfering it between membranes through the cytosol. Involved in maintenance of intracellular sterol distribution and homeostasis (PubMed:8017104, PubMed:11238399, PubMed:15173322). Involved in non-vesicular transport of ergosterol and PI(4)P at the NVJ. Binds sterol and PI4P in a mutually exclusive manner (PubMed:28319008). May be involved in formation of PMN vesicles by altering the membrane lipid composition (PubMed:15173322). {Experimental EvidencePubMed:11238399, Experimental EvidencePubMed:15173322, Experimental EvidencePubMed:28319008, Experimental EvidencePubMed:8017104}.
National and Kapodistrian University of Athens
Department of Biology
Biophysics & Bioinformatics Laboratory