National and Kapodistrian University of Athens
Department of Biology
Biophysics & Bioinformatics Laboratory
Protein Information |
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|---|---|
| Protein Name | Protein pid-1 |
| Accession Code | Q19541 |
| Gene | pid |
| Organism | Caenorhabditis elegans (Taxonomy: 6239) |
| Part of Reference Proteome? | Yes |
| Sequence (Length: 169) |
Description |
Position in the Nuclear Envelope |
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|---|---|---|
| Location | Location ID | Description |
| Perinuclear Region | SL-0198 | The perinuclear region is the cytoplasmic region just around the nucleus. | Membrane Topology |
| Topology | Source | Annotation Type |
| Unknown | UniProt | Sequence Analysis | Assigned Ontology terms |
Description |
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|---|---|
| Component of the pid-1 variant of the PETISCO complex which is required for the biogenesis of a class of 21 nucleotide PIWI- interacting RNAs (piRNAs) that possess a uracil residue at the 5'-end (also called 21U-RNAs) (PubMed:31147388, PubMed:31216475). Within the complex acts as an adapter which binds to the complex via erh-2 (PubMed:31147388). Involved in the biogenesis of 21U-RNAs which guide the piwi protein prg-1 to its DNA targets for silencing (PubMed:24696453, PubMed:33231880). Plays a role in small RNA-directed transgenerational epigenetic inheritance (PubMed:33231880). {Experimental EvidencePubMed:24696453, Experimental EvidencePubMed:31147388, Experimental EvidencePubMed:33231880, Curator InferencePubMed:31216475}. | Assigned Ontology terms |
Interactions with Nuclear Envelope proteins (4 interactors) |
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|---|---|---|---|
Interactions with other proteins (7 interactors) |
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National and Kapodistrian University of Athens
Department of Biology
Biophysics & Bioinformatics Laboratory