National and Kapodistrian University of Athens
Department of Biology
Biophysics & Bioinformatics Laboratory
Protein Information |
|
|---|---|
| Protein Name | Muscular LMNA-interacting protein |
| Accession Code | Q5VWP3 |
| Gene | MLIP |
| Organism | Homo sapiens | Human (Taxonomy: 9606) |
| Part of Reference Proteome? | Yes |
| Sequence (Length: 458) |
Description |
Position in the Nuclear Envelope |
|
|---|---|---|
| Location | Location ID | Description |
| Nuclear Envelope | SL-0178 | The nuclear envelope is a membrane system which surrounds the nucleoplasm of eukaryotic cells. It is composed of the nuclear lamina, nuclear pore complexes and two nuclear membranes. The space between the two membranes is called the nuclear intermembrane space. | Membrane Topology |
| Topology | Source | Annotation Type |
| Peripheral | UniProt | By Similarity {ECO:0000250|UniProtKB:Q5FW52} | Assigned Ontology terms |
Description |
|
|---|---|
| Required for precocious cardiac adaptation to stress through integrated regulation of the AKT/mTOR pathways and FOXO1. Regulates cardiac homeostasis and plays an important role in protection against cardiac hypertrophy. Acts as a transcriptional cofactor, represses transactivator activity of ISL1 and MYOCD. {By SimilarityUniProtKB:A0A096MK47, By SimilarityUniProtKB:Q5FW52}. | Assigned Ontology terms |
Description |
|
|---|---|
| Note=Expression is reduced in patients with dilated cardiomyocytes. In murine cardiomyopathy models, deletion of the encoding gene accelerates progress from hypertrophy to heart failure. {Experimental EvidencePubMed:26436652}. | Database Associations |
| OMIM | 614106 |
| DisGeNET | 90523 |
Interactions with Nuclear Envelope proteins (1 interactors) |
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|---|---|---|---|
Interactions with other proteins (1 interactors) |
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Database | Links |
| UNIPROT | Q5VWP3 B7Z2N0 D6RE05 Q96H08 Q96NF7 |
| Pfam | PF15274 |
| OMIM | 614106 |
| DisGeNET | 90523 |
National and Kapodistrian University of Athens
Department of Biology
Biophysics & Bioinformatics Laboratory