National and Kapodistrian University of Athens
Department of Biology
Biophysics & Bioinformatics Laboratory
Protein Information |
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| Protein Name | N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D |
| Accession Code | Q6IQ20 |
| Gene | NAPEPLD |
| Organism | Homo sapiens | Human (Taxonomy: 9606) |
| Part of Reference Proteome? | Yes |
| Sequence (Length: 393) |
Structure Viewer (PDB: 4QN9) |
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Description |
Position in the Nuclear Envelope |
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| Location | Location ID | Description |
| Nuclear Envelope | SL-0178 | The nuclear envelope is a membrane system which surrounds the nucleoplasm of eukaryotic cells. It is composed of the nuclear lamina, nuclear pore complexes and two nuclear membranes. The space between the two membranes is called the nuclear intermembrane space. | Membrane Topology |
| Topology | Source | Annotation Type |
| Peripheral | UniProt | Curator Inference {ECO:0000305|PubMed:25684574} | Assigned Ontology terms |
Description |
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|---|---|
| D-type phospholipase that hydrolyzes N-acyl- phosphatidylethanolamines (NAPEs) to produce bioactive N- acylethanolamines/fatty acid ethanolamides (NAEs/FAEs) and phosphatidic acid (PubMed:14634025, PubMed:16527816, PubMed:27571266, PubMed:25684574). Cleaves the terminal phosphodiester bond of diacyl- and alkenylacyl-NAPEs, primarily playing a role in the generation of long-chain saturated and monounsaturated NAEs in the brain (By similarity). May control NAPE homeostasis in dopaminergic neuron membranes and regulate neuron survival, partly through RAC1 activation (By similarity). As a regulator of lipid metabolism in the adipose tissue, mediates the crosstalk between adipocytes, gut microbiota and immune cells to control body temperature and weight. In particular, regulates energy homeostasis by promoting cold-induced brown or beige adipocyte differentiation program to generate heat from fatty acids and glucose. Has limited D-type phospholipase activity toward N-acyl lyso-NAPEs (By similarity). {By SimilarityUniProtKB:Q8BH82, Experimental EvidencePubMed:14634025, Experimental EvidencePubMed:16527816, Experimental EvidencePubMed:25684574, Experimental EvidencePubMed:27571266}. | Assigned Ontology terms |
Interactions with Nuclear Envelope proteins (1 interactors) |
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Interactions with other proteins (1 interactors) |
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Database | Links |
| UNIPROT | Q6IQ20 Q5CZ87 Q769K1 |
| PDB | 4QN9 |
| Pfam | PF12706 |
| OMIM | 612334 |
| DisGeNET | 222236 |
National and Kapodistrian University of Athens
Department of Biology
Biophysics & Bioinformatics Laboratory