Sortilin - Homo sapiens

Sortilin (Homo sapiens)

FASTA TEXT XML

Subcellular Location Biology & Function Disease Associations Interactions Cross-References

General Information

Protein Information
Protein Name	Sortilin
Accession Code	Q99523
Gene	SORT1
Organism	Homo sapiens \| Human (Taxonomy: 9606)
Part of Reference Proteome?	Yes
Sequence (Length: 831)
MERPWGAADGLSRWPHGLGLLLLLQLLPPSTLSQDRLDAPPPPAAPLPRWSGPIGVSWGLRAAAAGGAFPRGGRWRRSAP GEDEECGRVRDFVAKLANNTHQHVFDDLRGSVSLSWVGDSTGVILVLTTFHVPLVIMTFGQSKLYRSEDYGKNFKDITDL INNTFIRTEFGMAIGPENSGKVVLTAEVSGGSRGGRIFRSSDFAKNFVQTDLPFHPLTQMMYSPQNSDYLLALSTENGLW VSKNFGGKWEEIHKAVCLAKWGSDNTIFFTTYANGSCKADLGALELWRTSDLGKSFKTIGVKIYSFGLGGRFLFASVMAD KDTTRRIHVSTDQGDTWSMAQLPSVGQEQFYSILAANDDMVFMHVDEPGDTGFGTIFTSDDRGIVYSKSLDRHLYTTTGG ETDFTNVTSLRGVYITSVLSEDNSIQTMITFDQGGRWTHLRKPENSECDATAKNKNECSLHIHASYSISQKLNVPMAPLS EPNAVGIVIAHGSVGDAISVMVPDVYISDDGGYSWTKMLEGPHYYTILDSGGIIVAIEHSSRPINVIKFSTDEGQCWQTY TFTRDPIYFTGLASEPGARSMNISIWGFTESFLTSQWVSYTIDFKDILERNCEEKDYTIWLAHSTDPEDYEDGCILGYKE QFLRLRKSSVCQNGRDYVVTKQPSICLCSLEDFLCDFGYYRPENDSKCVEQPELKGHDLEFCLYGREEHLTTNGYRKIPG DKCQGGVNPVREVKDLKKKCTSNFLSPEKQNSKSNSVPIILAIVGLMLVTVVAGVLIVKKYVCGGRFLVHRYSVLQQHAE ANGVDGVDALDTASHTNKSGYHDDSDEDLLE

Structure Viewer (PDB: 5MRI)

Subcellular Location

Description
Golgi apparatus, Golgi stack membrane {Experimental EvidencePubMed:16787399, Experimental EvidencePubMed:18817523}; Single-pass type I membrane protein {Curator Inference}. Endosome membrane {Experimental EvidencePubMed:18817523}; Single-pass type I membrane protein {Curator Inference}. Endoplasmic reticulum membrane {Curator Inference}; Single- pass type I membrane protein {Curator Inference}. Nucleus membrane {Curator Inference}; Single-pass type I membrane protein {Curator Inference}. Cell membrane; Single-pass type I membrane protein; Extracellular side. Lysosome membrane {Curator Inference}; Single-pass type I membrane protein {Curator Inference}. Note=Localized to membranes of the endoplasmic reticulum, endosomes, Golgi stack, lysosomes and nucleus. A small fraction of the protein is also localized to the plasma membrane. May also be found in SLC2A4/GLUT4 storage vesicles (GSVs) in adipocytes. Localization to the plasma membrane in adipocytes may be enhanced by insulin.
Position in the Nuclear Envelope
Location	Location ID	Description
Nuclear Envelope	SL-0178	The nuclear envelope is a membrane system which surrounds the nucleoplasm of eukaryotic cells. It is composed of the nuclear lamina, nuclear pore complexes and two nuclear membranes. The space between the two membranes is called the nuclear intermembrane space.
Nuclear Membrane	SL-0182	The membrane surrounding the nucleus. This term is used when it is not known if the protein is found in or associated with the inner or outer nuclear membrane.
Membrane Topology
Topology	Source	Annotation Type
Transmembrane	UniProt	Sequence Analysis {ECO:0000255}
Assigned Ontology terms

Cellular Component	Cell Surface (GO:0009986) Clathrin-Coated Pit (GO:0005905) Clathrin-Coated Vesicle (GO:0030136) Cytoplasmic Vesicle (GO:0031410) Cytosol (GO:0005829) Early Endosome (GO:0005769) Endoplasmic Reticulum Membrane (GO:0005789) Endosome Membrane (GO:0010008) Golgi Apparatus (GO:0005794) Golgi Cisterna Membrane (GO:0032580) Lysosomal Membrane (GO:0005765) Lysosome (GO:0005764) Nuclear Membrane (GO:0031965) Perinuclear Region Of Cytoplasm (GO:0048471) Plasma Membrane (GO:0005886) Trans-Golgi Network Transport Vesicle (GO:0030140)

Biology & Function

Description
Functions as a sorting receptor in the Golgi compartment and as a clearance receptor on the cell surface. Required for protein transport from the Golgi apparatus to the lysosomes by a pathway that is independent of the mannose-6-phosphate receptor (M6PR). Lysosomal proteins bind specifically to the receptor in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelysosomal compartment where the low pH mediates the dissociation of the complex (PubMed:16787399). The receptor is then recycled back to the Golgi for another round of trafficking through its binding to the retromer. Also required for protein transport from the Golgi apparatus to the endosomes. Promotes neuronal apoptosis by mediating endocytosis of the proapoptotic precursor forms of BDNF (proBDNF) and NGFB (proNGFB). Also acts as a receptor for neurotensin. May promote mineralization of the extracellular matrix during osteogenic differentiation by scavenging extracellular LPL. Probably required in adipocytes for the formation of specialized storage vesicles containing the glucose transporter SLC2A4/GLUT4 (GLUT4 storage vesicles, or GSVs). These vesicles provide a stable pool of SLC2A4 and confer increased responsiveness to insulin. May also mediate transport from the endoplasmic reticulum to the Golgi. {Experimental EvidencePubMed:10085125, Experimental EvidencePubMed:11331584, Experimental EvidencePubMed:11390366, Experimental EvidencePubMed:12209882, Experimental EvidencePubMed:12598608, Experimental EvidencePubMed:14657016, Experimental EvidencePubMed:14985763, Experimental EvidencePubMed:15313463, Experimental EvidencePubMed:15930396, Experimental EvidencePubMed:15987945, Experimental EvidencePubMed:16787399, Experimental EvidencePubMed:18817523}.
Assigned Ontology terms

Biological Process	Endocytosis (GO:0006897) Endosome To Lysosome Transport (GO:0008333) Endosome Transport Via Multivesicular Body Sorting Pathway (GO:0032509) Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors (GO:0008625) G Protein-Coupled Receptor Signaling Pathway (GO:0007186) Glucose Import (GO:0046323) Golgi To Endosome Transport (GO:0006895) Golgi To Lysosome Transport (GO:0090160) Myotube Differentiation (GO:0014902) Negative Regulation Of Fat Cell Differentiation (GO:0045599) Negative Regulation Of Lipoprotein Lipase Activity (GO:0051005) Neuropeptide Signaling Pathway (GO:0007218) Neurotrophin TRK Receptor Signaling Pathway (GO:0048011) Ossification (GO:0001503) Plasma Membrane To Endosome Transport (GO:0048227) Post-Golgi Vesicle-Mediated Transport (GO:0006892) Protein Targeting To Lysosome (GO:0006622) Regulation Of Gene Expression (GO:0010468) Response To Insulin (GO:0032868) Vesicle Organization (GO:0016050)
Molecular Function	Enzyme Binding (GO:0019899) Nerve Growth Factor Binding (GO:0048406) Nerve Growth Factor Receptor Activity (GO:0010465) Neurotensin Receptor Activity, Non-G Protein-Coupled (GO:0030379) Retromer Complex Binding (GO:1905394)

Disease associations

Description
Note=A common polymorphism located in a non-coding region between CELSR2 and PSRC1 alters a CEBP transcription factor binding site and is responsible for changes in hepatic expression of SORT1. Altered SORT1 expression in liver affects low density lipoprotein cholesterol levels in plasma and is associated with susceptibility to myocardial infarction. {Experimental EvidencePubMed:20686566}.
Database Associations
OMIM	602458 613589
DisGeNET	6272

Protein-Protein Interactions

Interactions with Nuclear Envelope proteins (9 interactors)

Partner (NucEnvDB)		IntAct	Confidence score
Q99523	Self	EBI-25396647	0.68
Q9UPY3	Endoribonuclease Dicer	EBI-11154667	0.35
P03246	E1B protein, small T-antigen	EBI-11722343	0.35
Q6PIV2	Forkhead box protein R1	EBI-11321774	0.35
Q8NC56	LEM domain-containing protein 2	EBI-11154667	0.35
Q86WG5	Myotubularin-related protein 13	EBI-11154667	0.35
Q16620	BDNF/NT-3 growth factors receptor	EBI-9828457	0.44
Q63604	BDNF/NT-3 growth factors receptor	EBI-9663445	0.43
Q92900	Regulator of nonsense transcripts 1	EBI-11154667	0.35
Interactions with other proteins (163 interactors)

Partner (UniProt)		IntAct	Confidence score
Q9UJY4	ADP-ribosylation factor-binding protein GGA2 (Gamma-adaptin-related protein 2) (Golgi-localized, gamma ear-containing, ARF-binding protein 2) (VHS domain and ear domain of gamma-adaptin) (Vear)	EBI-7835669	0.70
Q9UJY5	ADP-ribosylation factor-binding protein GGA1 (Gamma-adaptin-related protein 1) (Golgi-localized, gamma ear-containing, ARF-binding protein 1)	EBI-7866420	0.67
P24941	Cyclin-dependent kinase 2 (EC 2.7.11.22) (Cell division protein kinase 2) (p33 protein kinase)	EBI-11154667	0.56
P28799	Progranulin (PGRN) (Acrogranin) (Epithelin precursor) (Glycoprotein of 88 Kda) (GP88) (Glycoprotein 88) (Granulin precursor) (PC cell-derived growth factor) (PCDGF) (Proepithelin) (PEPI) [Cleaved into: Paragranulin; Granulin-1 (Granulin G); Granulin-2 (Granulin F); Granulin-3 (Epithelin-2) (Granulin B); Granulin-4 (Epithelin-1) (Granulin A); Granulin-5 (Granulin C); Granulin-6 (Granulin D); Granulin-7 (Granulin E)]	EBI-8759908	0.61
P11151	Lipoprotein lipase (LPL) (EC 3.1.1.34) (Phospholipase A1) (EC 3.1.1.32)	EBI-8794584	0.66
P30533	Alpha-2-macroglobulin receptor-associated protein (Alpha-2-MRAP) (Low density lipoprotein receptor-related protein-associated protein 1) (RAP)	EBI-8794629	0.81
P06858	Lipoprotein lipase (LPL) (EC 3.1.1.34) (Phospholipase A1) (EC 3.1.1.32)	EBI-8795527	0.44
P01138	Beta-nerve growth factor (Beta-NGF)	EBI-9253924	0.68
P30990	Neurotensin/neuromedin N [Cleaved into: Large neuromedin N (NmN-125); Neuromedin N (NN) (NmN); Neurotensin (NT); Tail peptide]	EBI-25298265	0.70
P08138	Tumor necrosis factor receptor superfamily member 16 (Gp80-LNGFR) (Low affinity neurotrophin receptor p75NTR) (Low-affinity nerve growth factor receptor) (NGF receptor) (p75 ICD) (CD antigen CD271)	EBI-9346945	0.40
Q8IVD9	NudC domain-containing protein 3	EBI-9395191	0.35
P54256	Huntingtin-associated protein 1 (HAP-1)	EBI-9663445	0.43
Q16288	NT-3 growth factor receptor (EC 2.7.10.1) (GP145-TrkC) (Trk-C) (Neurotrophic tyrosine kinase receptor type 3) (TrkC tyrosine kinase)	EBI-9827681	0.54
P04629	High affinity nerve growth factor receptor (EC 2.7.10.1) (Neurotrophic tyrosine kinase receptor type 1) (TRK1-transforming tyrosine kinase protein) (Tropomyosin-related kinase A) (Tyrosine kinase receptor) (Tyrosine kinase receptor A) (Trk-A) (gp140trk) (p140-TrkA)	EBI-9827696	0.46
Q14653	Interferon regulatory factor 3 (IRF-3)	EBI-11321946	0.35
P0CK56	Uncharacterized protein BDLF4	EBI-11725466	0.35
Q2MG95	BVLF1	EBI-11733653	0.35
Q8IXK0	Polyhomeotic-like protein 2 (hPH2) (Early development regulatory protein 2)	EBI-11154667	0.35
Q7Z7F7	39S ribosomal protein L55, mitochondrial (L55mt) (MRP-L55) (Mitochondrial large ribosomal subunit protein bL31m) (Mitochondrial large ribosomal subunit protein mL55)	EBI-11154667	0.35
O43543	DNA repair protein XRCC2 (X-ray repair cross-complementing protein 2)	EBI-11154667	0.35
Q8IZY2	Phospholipid-transporting ATPase ABCA7 (EC 7.6.2.1) (ABCA-SSN) (ATP-binding cassette sub-family A member 7) (Autoantigen SS-N) (Macrophage ABC transporter)	EBI-11154667	0.35
Q6KCM7	Calcium-binding mitochondrial carrier protein SCaMC-2 (Mitochondrial ATP-Mg/Pi carrier protein 3) (Mitochondrial Ca(2+)-dependent solute carrier protein 3) (Small calcium-binding mitochondrial carrier protein 2) (Solute carrier family 25 member 25)	EBI-11154667	0.35
Q8N8A6	ATP-dependent RNA helicase DDX51 (EC 3.6.4.13) (DEAD box protein 51)	EBI-11154667	0.35
O95678	Keratin, type II cytoskeletal 75 (Cytokeratin-75) (CK-75) (Keratin-6 hair follicle) (hK6hf) (Keratin-75) (K75) (Type II keratin-K6hf) (Type-II keratin Kb18)	EBI-11154667	0.35
Q6PKC3	Thioredoxin domain-containing protein 11 (EF-hand-binding protein 1)	EBI-11154667	0.35
J3KP15	Serine/arginine-rich splicing factor 2 (Splicing component, 35 kDa) (Splicing factor SC35) (Splicing factor, arginine/serine-rich 2)	EBI-11154667	0.35
Q9BQE3	Tubulin alpha-1C chain (EC 3.6.5.-) (Alpha-tubulin 6) (Tubulin alpha-6 chain) [Cleaved into: Detyrosinated tubulin alpha-1C chain]	EBI-11154667	0.35
Q8IXQ6	Protein mono-ADP-ribosyltransferase PARP9 (EC 2.4.2.-) (ADP-ribosyltransferase diphtheria toxin-like 9) (ARTD9) (B aggressive lymphoma protein) (Poly [ADP-ribose] polymerase 9) (PARP-9)	EBI-11154667	0.35
Q86YS7	C2 domain-containing protein 5 (C2 domain-containing phosphoprotein of 138 kDa)	EBI-11154667	0.35
Q9H6R4	Nucleolar protein 6 (Nucleolar RNA-associated protein) (Nrap)	EBI-11154667	0.35
G5E9A6	Ubiquitin carboxyl-terminal hydrolase (EC 3.4.19.12)	EBI-11154667	0.35
Q9P0T7	Proton-transporting V-type ATPase complex assembly regulator TMEM9 (v-ATPase assembly regulator TMEM9) (Dermal papilla-derived protein 4) (Transmembrane protein 9) (Protein TMEM9)	EBI-11154667	0.35
O43504	Ragulator complex protein LAMTOR5 (Hepatitis B virus X-interacting protein) (HBV X-interacting protein) (HBX-interacting protein) (Late endosomal/lysosomal adaptor and MAPK and MTOR activator 5)	EBI-11154667	0.35
H3BS42	Zinc finger protein 768	EBI-11154667	0.35
Q96AY2	Crossover junction endonuclease EME1 (EC 3.1.22.-) (MMS4 homolog) (hMMS4)	EBI-11154667	0.35
O43674	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial (Complex I-SGDH) (CI-SGDH) (NADH-ubiquinone oxidoreductase SGDH subunit)	EBI-11154667	0.35
Q9UHR4	Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1 (BAI1-associated protein 2-like protein 1) (Insulin receptor tyrosine kinase substrate)	EBI-11154667	0.35
Q9H2D6	TRIO and F-actin-binding protein (Protein Tara) (Trio-associated repeat on actin)	EBI-11154667	0.35
Q9BXF6	Rab11 family-interacting protein 5 (Rab11-FIP5) (Gamma-SNAP-associated factor 1) (Gaf-1) (Phosphoprotein pp75) (Rab11-interacting protein Rip11)	EBI-11154667	0.35
H3BNT4	M-phase phosphoprotein 6	EBI-11154667	0.35
P78368	Casein kinase I isoform gamma-2 (CKI-gamma 2) (EC 2.7.11.1)	EBI-11154667	0.35
Q6T4R5	Actin remodeling regulator NHS (Congenital cataracts and dental anomalies protein) (Nance-Horan syndrome protein)	EBI-11154667	0.35
Q9Y2H6	Fibronectin type-III domain-containing protein 3A (Human gene expressed in odontoblasts)	EBI-11154667	0.35
Q8IWU2	Serine/threonine-protein kinase LMTK2 (EC 2.7.11.1) (Apoptosis-associated tyrosine kinase 2) (Brain-enriched kinase) (hBREK) (CDK5/p35-regulated kinase) (CPRK) (Kinase/phosphatase/inhibitor 2) (Lemur tyrosine kinase 2) (Serine/threonine-protein kinase KPI-2)	EBI-11154667	0.35
Q86WP2	Vasculin (GC-rich promoter-binding protein 1) (Vascular wall-linked protein)	EBI-11154667	0.35
Q9Y6X9	ATPase MORC2 (EC 3.6.1.-) (MORC family CW-type zinc finger protein 2) (Zinc finger CW-type coiled-coil domain protein 1)	EBI-11154667	0.35
Q14684	Ribosomal RNA processing protein 1 homolog B (RRP1-like protein B)	EBI-11154667	0.35
Q9BZF9	Uveal autoantigen with coiled-coil domains and ankyrin repeats	EBI-11154667	0.35
Q7Z7K6	Centromere protein V (CENP-V) (Nuclear protein p30) (Proline-rich protein 6)	EBI-11154667	0.35
P12882	Myosin-1 (Myosin heavy chain 1) (Myosin heavy chain 2x) (MyHC-2x) (Myosin heavy chain IIx/d) (MyHC-IIx/d) (Myosin heavy chain, skeletal muscle, adult 1)	EBI-11154667	0.35
Q8N8R5	Mitochondrial protein C2orf69	EBI-11154667	0.35
G5E9S8	Kinesin light chain	EBI-11154667	0.35
P98170	E3 ubiquitin-protein ligase XIAP (EC 2.3.2.27) (Baculoviral IAP repeat-containing protein 4) (IAP-like protein) (ILP) (hILP) (Inhibitor of apoptosis protein 3) (IAP-3) (hIAP-3) (hIAP3) (RING-type E3 ubiquitin transferase XIAP) (X-linked inhibitor of apoptosis protein) (X-linked IAP)	EBI-11154667	0.35
O94782	Ubiquitin carboxyl-terminal hydrolase 1 (EC 3.4.19.12) (Deubiquitinating enzyme 1) (hUBP) (Ubiquitin thioesterase 1) (Ubiquitin-specific-processing protease 1) [Cleaved into: Ubiquitin carboxyl-terminal hydrolase 1, N-terminal fragment]	EBI-11154667	0.35
Q9H792	Inactive tyrosine-protein kinase PEAK1 (Pseudopodium-enriched atypical kinase 1) (Sugen kinase 269) (Tyrosine-protein kinase SgK269)	EBI-11154667	0.35
Q92934	Bcl2-associated agonist of cell death (BAD) (Bcl-2-binding component 6) (Bcl-2-like protein 8) (Bcl2-L-8) (Bcl-xL/Bcl-2-associated death promoter) (Bcl2 antagonist of cell death)	EBI-11154667	0.35
P06493	Cyclin-dependent kinase 1 (CDK1) (EC 2.7.11.22) (EC 2.7.11.23) (Cell division control protein 2 homolog) (Cell division protein kinase 1) (p34 protein kinase)	EBI-11154667	0.35
Q9NYU1	UDP-glucose:glycoprotein glucosyltransferase 2 (UGT2) (hUGT2) (EC 2.4.1.-) (UDP--Glc:glycoprotein glucosyltransferase 2) (UDP-glucose ceramide glucosyltransferase-like 1)	EBI-11154667	0.35
E9PRI1	Crossover junction endonuclease MUS81 (EC 3.1.22.-)	EBI-11154667	0.35
O00308	NEDD4-like E3 ubiquitin-protein ligase WWP2 (EC 2.3.2.26) (Atrophin-1-interacting protein 2) (AIP2) (HECT-type E3 ubiquitin transferase WWP2) (WW domain-containing protein 2)	EBI-11154667	0.35
Q9NP74	Palmdelphin (Paralemmin-like protein)	EBI-11154667	0.35
O60506	Heterogeneous nuclear ribonucleoprotein Q (hnRNP Q) (Glycine- and tyrosine-rich RNA-binding protein) (GRY-RBP) (NS1-associated protein 1) (Synaptotagmin-binding, cytoplasmic RNA-interacting protein)	EBI-11154667	0.35
Q16222	UDP-N-acetylhexosamine pyrophosphorylase (Antigen X) (AGX) (Sperm-associated antigen 2) [Includes: UDP-N-acetylgalactosamine pyrophosphorylase (EC 2.7.7.83) (AGX-1); UDP-N-acetylglucosamine pyrophosphorylase (EC 2.7.7.23) (AGX-2)]	EBI-11154667	0.35
Q9NW13	RNA-binding protein 28 (RNA-binding motif protein 28)	EBI-11154667	0.35
O15020	Spectrin beta chain, non-erythrocytic 2 (Beta-III spectrin) (Spinocerebellar ataxia 5 protein)	EBI-11154667	0.35
Q8WW22	DnaJ homolog subfamily A member 4	EBI-11154667	0.35
Q15646	2'-5'-oligoadenylate synthase-like protein (2'-5'-OAS-related protein) (2'-5'-OAS-RP) (59 kDa 2'-5'-oligoadenylate synthase-like protein) (Thyroid receptor-interacting protein 14) (TR-interacting protein 14) (TRIP-14) (p59 OASL) (p59OASL)	EBI-11154667	0.35
Q8TED0	U3 small nucleolar RNA-associated protein 15 homolog	EBI-11154667	0.35
Q6PCT2	F-box/LRR-repeat protein 19 (F-box and leucine-rich repeat protein 19)	EBI-11154667	0.35
Q13867	Bleomycin hydrolase (BH) (BLM hydrolase) (BMH) (EC 3.4.22.40)	EBI-11154667	0.35
P07437	Tubulin beta chain (Tubulin beta-5 chain)	EBI-11154667	0.35
G3V5I9	CMT1A duplicated region transcript 4 protein	EBI-11154667	0.35
P00738	Haptoglobin (Zonulin) [Cleaved into: Haptoglobin alpha chain; Haptoglobin beta chain]	EBI-11154667	0.35
P46087	Probable 28S rRNA (cytosine(4447)-C(5))-methyltransferase (EC 2.1.1.-) (Nucleolar protein 1) (Nucleolar protein 2 homolog) (Proliferating-cell nucleolar antigen p120) (Proliferation-associated nucleolar protein p120)	EBI-11154667	0.35
Q9Y2L1	Exosome complex exonuclease RRP44 (EC 3.1.13.-) (EC 3.1.26.-) (Protein DIS3 homolog) (Ribosomal RNA-processing protein 44)	EBI-11154667	0.35
Q8TDN6	Ribosome biogenesis protein BRX1 homolog (Brix domain-containing protein 2)	EBI-11154667	0.35
O60287	Nucleolar pre-ribosomal-associated protein 1 (Nucleolar protein 254 kDa) (URB1 ribosome biogenesis 1 homolog)	EBI-11154667	0.35
H0YAJ5	Amyloid beta precursor protein-binding family B member 2	EBI-11154667	0.35
Q96MF7	E3 SUMO-protein ligase NSE2 (EC 2.3.2.-) (E3 SUMO-protein transferase NSE2) (MMS21 homolog) (hMMS21) (Non-structural maintenance of chromosomes element 2 homolog) (Non-SMC element 2 homolog)	EBI-11154667	0.35
P67809	Y-box-binding protein 1 (YB-1) (CCAAT-binding transcription factor I subunit A) (CBF-A) (DNA-binding protein B) (DBPB) (Enhancer factor I subunit A) (EFI-A) (Nuclease-sensitive element-binding protein 1) (Y-box transcription factor)	EBI-11154667	0.35
Q9Y4E8	Ubiquitin carboxyl-terminal hydrolase 15 (EC 3.4.19.12) (Deubiquitinating enzyme 15) (Ubiquitin thioesterase 15) (Ubiquitin-specific-processing protease 15) (Unph-2) (Unph4)	EBI-11154667	0.35
P53621	Coatomer subunit alpha (Alpha-coat protein) (Alpha-COP) (HEP-COP) (HEPCOP) [Cleaved into: Xenin (Xenopsin-related peptide); Proxenin]	EBI-11154667	0.35
A7KAX9	Rho GTPase-activating protein 32 (Brain-specific Rho GTPase-activating protein) (GAB-associated Cdc42/Rac GTPase-activating protein) (GC-GAP) (GTPase regulator interacting with TrkA) (Rho-type GTPase-activating protein 32) (Rho/Cdc42/Rac GTPase-activating protein RICS) (RhoGAP involved in the beta-catenin-N-cadherin and NMDA receptor signaling) (p200RhoGAP) (p250GAP)	EBI-11154667	0.35
Q96A35	39S ribosomal protein L24, mitochondrial (L24mt) (MRP-L24) (Mitochondrial large ribosomal subunit protein uL24m)	EBI-11154667	0.35
Q9NXA8	NAD-dependent protein deacylase sirtuin-5, mitochondrial (EC 2.3.1.-) (Regulatory protein SIR2 homolog 5) (SIR2-like protein 5)	EBI-11154667	0.35
Q8IY21	Probable ATP-dependent RNA helicase DDX60 (EC 3.6.4.13) (DEAD box protein 60)	EBI-11154667	0.35
G4U4J3	PAP associated domain containing 5	EBI-11154667	0.35
P42680	Tyrosine-protein kinase Tec (EC 2.7.10.2)	EBI-11154667	0.35
Q08378	Golgin subfamily A member 3 (Golgi complex-associated protein of 170 kDa) (GCP170) (Golgin-160)	EBI-11154667	0.35
Q8NCE0	tRNA-splicing endonuclease subunit Sen2 (EC 4.6.1.16) (tRNA-intron endonuclease Sen2) (HsSen2)	EBI-11154667	0.35
P07949	Proto-oncogene tyrosine-protein kinase receptor Ret (EC 2.7.10.1) (Cadherin family member 12) (Proto-oncogene c-Ret) [Cleaved into: Soluble RET kinase fragment; Extracellular cell-membrane anchored RET cadherin 120 kDa fragment]	EBI-11154667	0.35
Q6IN84	rRNA methyltransferase 1, mitochondrial (EC 2.1.1.-) (16S rRNA (guanosine(1145)-2'-O)-methyltransferase) (16S rRNA [Gm1145] 2'-O-methyltransferase)	EBI-11154667	0.35
Q13428	Treacle protein (Treacher Collins syndrome protein)	EBI-11154667	0.35
P51659	Peroxisomal multifunctional enzyme type 2 (MFE-2) (17-beta-hydroxysteroid dehydrogenase 4) (17-beta-HSD 4) (D-bifunctional protein) (DBP) (Multifunctional protein 2) (MFP-2) (Short chain dehydrogenase/reductase family 8C member 1) [Cleaved into: (3R)-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.n12); Enoyl-CoA hydratase 2 (EC 4.2.1.107) (EC 4.2.1.119) (3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholest-24-enoyl-CoA hydratase)]	EBI-11154667	0.35
C9J6P4	Zinc finger CCCH-type antiviral protein 1	EBI-11154667	0.35
Q659A1	Little elongation complex subunit 2 (Interactor of little elongator complex ELL subunit 2) (NMDA receptor-regulated protein 2)	EBI-11154667	0.35
Q6L8Q7	2',5'-phosphodiesterase 12 (2'-PDE) (2-PDE) (EC 3.1.4.-) (Mitochondrial deadenylase) (EC 3.1.13.4)	EBI-11154667	0.35
Q14146	Unhealthy ribosome biogenesis protein 2 homolog	EBI-11154667	0.35
Q14232	Translation initiation factor eIF-2B subunit alpha (eIF-2B GDP-GTP exchange factor subunit alpha)	EBI-11154667	0.35
P00966	Argininosuccinate synthase (EC 6.3.4.5) (Citrulline--aspartate ligase)	EBI-11154667	0.35
J3KNB8	Mitogen-activated protein kinase kinase kinase 4	EBI-11154667	0.35
A1X283	SH3 and PX domain-containing protein 2B (Adapter protein HOFI) (Factor for adipocyte differentiation 49) (Tyrosine kinase substrate with four SH3 domains)	EBI-11154667	0.35
Q9Y2U9	Kelch domain-containing protein 2 (Hepatocellular carcinoma-associated antigen 33) (Host cell factor homolog LCP) (Host cell factor-like protein 1) (HCLP-1)	EBI-11154667	0.35
P51153	Ras-related protein Rab-13 (Cell growth-inhibiting gene 4 protein)	EBI-11154667	0.35
Q53SF7	Cordon-bleu protein-like 1	EBI-11154667	0.35
Q96CS3	FAS-associated factor 2 (Protein ETEA) (UBX domain-containing protein 3B) (UBX domain-containing protein 8)	EBI-11154667	0.35
Q01970	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-3 (EC 3.1.4.11) (Phosphoinositide phospholipase C-beta-3) (Phospholipase C-beta-3) (PLC-beta-3)	EBI-11154667	0.35
Q92733	Proline-rich protein PRCC (Papillary renal cell carcinoma translocation-associated gene protein)	EBI-11154667	0.35
Q8IYD8	Fanconi anemia group M protein (Protein FACM) (EC 3.6.4.13) (ATP-dependent RNA helicase FANCM) (Fanconi anemia-associated polypeptide of 250 kDa) (FAAP250) (Protein Hef ortholog)	EBI-11154667	0.35
P13533	Myosin-6 (Myosin heavy chain 6) (Myosin heavy chain, cardiac muscle alpha isoform) (MyHC-alpha)	EBI-11154667	0.35
Q6UVK1	Chondroitin sulfate proteoglycan 4 (Chondroitin sulfate proteoglycan NG2) (Melanoma chondroitin sulfate proteoglycan) (Melanoma-associated chondroitin sulfate proteoglycan)	EBI-11154667	0.35
Q9UHL9	General transcription factor II-I repeat domain-containing protein 1 (GTF2I repeat domain-containing protein 1) (General transcription factor III) (MusTRD1/BEN) (Muscle TFII-I repeat domain-containing protein 1) (Slow-muscle-fiber enhancer-binding protein) (USE B1-binding protein) (Williams-Beuren syndrome chromosomal region 11 protein) (Williams-Beuren syndrome chromosomal region 12 protein)	EBI-11154667	0.35
P42356	Phosphatidylinositol 4-kinase alpha (PI4-kinase alpha) (PI4K-alpha) (PtdIns-4-kinase alpha) (EC 2.7.1.67) (Phosphatidylinositol 4-Kinase III alpha)	EBI-11154667	0.35
Q5JRA6	Transport and Golgi organization protein 1 homolog (TANGO1) (C219-reactive peptide) (D320) (Melanoma inhibitory activity protein 3)	EBI-11154667	0.35
Q71F56	Mediator of RNA polymerase II transcription subunit 13-like (Mediator complex subunit 13-like) (Thyroid hormone receptor-associated protein 2) (Thyroid hormone receptor-associated protein complex 240 kDa component-like)	EBI-11154667	0.35
P54577	Tyrosine--tRNA ligase, cytoplasmic (EC 6.1.1.1) (Tyrosyl-tRNA synthetase) (TyrRS) [Cleaved into: Tyrosine--tRNA ligase, cytoplasmic, N-terminally processed]	EBI-11154667	0.35
Q8TE77	Protein phosphatase Slingshot homolog 3 (EC 3.1.3.16) (EC 3.1.3.48) (SSH-like protein 3) (SSH-3L) (hSSH-3L)	EBI-11154667	0.35
Q8ND56	Protein LSM14 homolog A (Protein FAM61A) (Protein SCD6 homolog) (Putative alpha-synuclein-binding protein) (AlphaSNBP) (RNA-associated protein 55A) (hRAP55) (hRAP55A)	EBI-11154667	0.35
Q8NFA0	Ubiquitin carboxyl-terminal hydrolase 32 (EC 3.4.19.12) (Deubiquitinating enzyme 32) (Renal carcinoma antigen NY-REN-60) (Ubiquitin thioesterase 32) (Ubiquitin-specific-processing protease 32)	EBI-11154667	0.35
Q9Y490	Talin-1	EBI-11154667	0.35
Q9UMF0	Intercellular adhesion molecule 5 (ICAM-5) (Telencephalin)	EBI-11154667	0.35
Q96P70	Importin-9 (Imp9) (Ran-binding protein 9) (RanBP9)	EBI-11154667	0.35
Q7Z2E3	Aprataxin (EC 3.6.1.71) (EC 3.6.1.72) (Forkhead-associated domain histidine triad-like protein) (FHA-HIT)	EBI-11154667	0.35
Q9NQY0	Bridging integrator 3	EBI-11154667	0.35
Q9NUQ7	Ufm1-specific protease 2 (UfSP2) (EC 3.4.22.-)	EBI-11154667	0.35
Q13488	V-type proton ATPase 116 kDa subunit a 3 (V-ATPase 116 kDa subunit a 3) (Osteoclastic proton pump 116 kDa subunit) (OC-116 kDa) (OC116) (T-cell immune regulator 1) (T-cell immune response cDNA7 protein) (TIRC7) (Vacuolar proton translocating ATPase 116 kDa subunit a isoform 3)	EBI-11154667	0.35
Q96A73	Putative monooxygenase p33MONOX (EC 1.-.-.-) (Brain-derived rescue factor p60MONOX) (Flavin monooxygenase motif-containing protein of 33 kDa)	EBI-11154667	0.35
P43307	Translocon-associated protein subunit alpha (TRAP-alpha) (Signal sequence receptor subunit alpha) (SSR-alpha)	EBI-11154667	0.35
Q92520	Protein FAM3C (Interleukin-like EMT inducer)	EBI-22754816	0.56
O95183	Vesicle-associated membrane protein 5 (VAMP-5) (Myobrevin)	EBI-22756180	0.56
Q6PL45	BRICHOS domain-containing protein 5	EBI-25279435	0.56
Q8TBE1	Protein cornichon homolog 3 (CNIH-3) (Cornichon family AMPA receptor auxiliary protein 3)	EBI-24650011	0.56
P02787	Serotransferrin (Transferrin) (Beta-1 metal-binding globulin) (Siderophilin)	EBI-24758574	0.56
P23560	Brain-derived neurotrophic factor (BDNF) (Abrineurin) [Cleaved into: BDNF precursor form (ProBDNF)]	EBI-24760183	0.56
Q96K78	Adhesion G-protein coupled receptor G7 (G-protein coupled receptor 128)	EBI-25271609	0.56
Q20MH8	Matrix protein 2 (Proton channel protein M2)	EBI-12586258	0.35
Q15077	P2Y purinoceptor 6 (P2Y6)	EBI-21272198	0.35
P05067	Amyloid-beta precursor protein (APP) (ABPP) (APPI) (Alzheimer disease amyloid A4 protein homolog) (Alzheimer disease amyloid protein) (Amyloid precursor protein) (Amyloid-beta (A4) precursor protein) (Amyloid-beta A4 protein) (Cerebral vascular amyloid peptide) (CVAP) (PreA4) (Protease nexin-II) (PN-II) [Cleaved into: N-APP; Soluble APP-alpha (S-APP-alpha); Soluble APP-beta (S-APP-beta); C99 (Beta-secretase C-terminal fragment) (Beta-CTF); Amyloid-beta protein 42 (Abeta42) (Beta-APP42); Amyloid-beta protein 40 (Abeta40) (Beta-APP40); C83 (Alpha-secretase C-terminal fragment) (Alpha-CTF); P3(42); P3(40); C80; Gamma-secretase C-terminal fragment 59 (Amyloid intracellular domain 59) (AICD-59) (AID(59)) (Gamma-CTF(59)); Gamma-secretase C-terminal fragment 57 (Amyloid intracellular domain 57) (AICD-57) (AID(57)) (Gamma-CTF(57)); Gamma-secretase C-terminal fragment 50 (Amyloid intracellular domain 50) (AICD-50) (AID(50)) (Gamma-CTF(50)); C31]	EBI-21183114	0.54
P26441	Ciliary neurotrophic factor (CNTF)	EBI-25298162	0.57
Q9UBD9	Cardiotrophin-like cytokine factor 1 (B-cell-stimulating factor 3) (BSF-3) (Novel neurotrophin-1) (NNT-1)	EBI-25298249	0.40
O75462	Cytokine receptor-like factor 1 (Cytokine-like factor 1) (CLF-1) (ZcytoR5)	EBI-25298249	0.40
P83714	Cardiotrophin-2 (CT-2) (Neuropoietin) (Np)	EBI-25298290	0.54
Q16619	Cardiotrophin-1 (CT-1)	EBI-25298330	0.44
P15018	Leukemia inhibitory factor (LIF) (Differentiation-stimulating factor) (D factor) (Melanoma-derived LPL inhibitor) (MLPLI) (Emfilermin)	EBI-25298341	0.44
P13725	Oncostatin-M (OSM)	EBI-25298353	0.44
P42702	Leukemia inhibitory factor receptor (LIF receptor) (LIF-R) (CD antigen CD118)	EBI-25298362	0.51
P05231	Interleukin-6 (IL-6) (B-cell stimulatory factor 2) (BSF-2) (CTL differentiation factor) (CDF) (Hybridoma growth factor) (Interferon beta-2) (IFN-beta-2)	EBI-25396627	0.57
P01580	Interferon gamma (IFN-gamma)	EBI-25396634	0.44
Q9JLC4	VPS10 domain-containing receptor SorCS1 (mSorCS)	EBI-25300430	0.54
Q8WY21	VPS10 domain-containing receptor SorCS1 (hSorCS)	EBI-25300575	0.54
P06280	Alpha-galactosidase A (EC 3.2.1.22) (Alpha-D-galactosidase A) (Alpha-D-galactoside galactohydrolase) (Galactosylgalactosylglucosylceramidase GLA) (Melibiase) (Agalsidase)	EBI-25396912	0.59
P01266	Thyroglobulin (Tg)	EBI-25406637	0.54
P06882	Thyroglobulin (Tg)	EBI-25406672	0.54
P20068	Neurotensin/neuromedin N [Cleaved into: Large neuromedin N (NmN-125); Neuromedin N (NN) (NmN); Neurotensin (NT); Tail peptide]	EBI-25406716	0.40
P01267	Thyroglobulin (Tg)	EBI-25408014	0.40
O96028	Histone-lysine N-methyltransferase NSD2 (EC 2.1.1.357) (Multiple myeloma SET domain-containing protein) (MMSET) (Nuclear SET domain-containing protein 2) (Protein trithorax-5) (Wolf-Hirschhorn syndrome candidate 1 protein)	EBI-25486814	0.35
P0DTD8	ORF7b protein (ORF7b) (Accessory protein 7b)	EBI-25687199	0.35
Q7TFA1	Protein non-structural 7b (ns7b) (Accessory protein 7b)	EBI-25688644	0.35
Q9UBQ0	Vacuolar protein sorting-associated protein 29 (hVPS29) (PEP11 homolog) (Vesicle protein sorting 29)	EBI-25890950	0.56
Q13363	C-terminal-binding protein 1 (CtBP1) (EC 1.1.1.-)	EBI-27045766	0.35
Q8IV63	Inactive serine/threonine-protein kinase VRK3 (Serine/threonine-protein pseudokinase VRK3) (Vaccinia-related kinase 3)	EBI-28942353	0.35
Q96KG9	N-terminal kinase-like protein (Coated vesicle-associated kinase of 90 kDa) (SCY1-like protein 1) (Telomerase regulation-associated protein) (Telomerase transcriptional element-interacting factor) (Teratoma-associated tyrosine kinase)	EBI-28944481	0.35
Q92932	Receptor-type tyrosine-protein phosphatase N2 (R-PTP-N2) (EC 3.1.3.-) (EC 3.1.3.48) (Islet cell autoantigen-related protein) (IAR) (ICAAR) (Phogrin) [Cleaved into: IA-2beta60]	EBI-27115082	0.35

Cross-References

Database	Links
UNIPROT	Q99523 B4DWI3 C0JYZ0 Q8IZ49
PDB	3F6K 3G2U 3G2V 4MSL 4N7E 4PO7 5MRH 5MRI 6EHO 6X3L 6X48 6X4H
Pfam	PF15902 PF15901
OMIM	602458 613589
DisGeNET	6272

Sortilin (Homo sapiens)

General Information

Protein Information

Structure Viewer (PDB: 5MRI)

Subcellular Location

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Position in the Nuclear Envelope

Membrane Topology

Assigned Ontology terms

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Assigned Ontology terms

Disease associations

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Database Associations

Protein-Protein Interactions

Interactions with Nuclear Envelope proteins (9 interactors)

Interactions with other proteins (163 interactors)

Cross-References

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Description

Description