NucEnvDB

NucEnvDB

A database of Nuclear Envelope Proteins and their Interactions

Huntingtin-interacting protein 1-related protein - Mus musculus - NucEnvDB

Huntingtin-interacting protein 1-related protein (Mus musculus)

FASTA TEXT XML

Subcellular Location Biology & Function Interactions Cross-References

General Information

Protein Information
Protein Name	Huntingtin-interacting protein 1-related protein
Accession Code	Q9JKY5
Gene	Hip1r
Organism	Mus musculus \| House mouse (Taxonomy: 10090)
Part of Reference Proteome?	Yes
Sequence (Length: 1068)
MNSIKNVPARVLSRRPGHSLEAEREQFDKTQAISISKAINSQEAPVKEKHARRIILGTHHEKGAFTFWSYAIGLPLSSSSILSWKFCHVLHKVLRDGHPNVLHDYQRYRSNIREIGDLWGHLRDQYGHLV NIYTKLLLTKISFHLKHPQFPAGLEVTDEVLEKAAGTDVNNIFQLTVEMFDYMDCELKLSESVFRQLNTAIAVSQMSSGQCRLAPLIQVIQDCSHLYHYTVKLMFKLHSCLPADTLQGHRDRFHEQFHSL KNFFRRASDMLYFKRLIQIPRLPEGPPNFLRASALAEHIKPVVVIPEEAPEEEEPENLIEISSAPPAGEPVVVADLFDQTFGPPNGSMKDDRDLQIENLKREVETLRAELEKIKMEAQRYISQLKGQVNG LEAELEEQRKQKQKALVDNEQLRHELAQLKALQLEGARNQGLREEAERKASATEARYSKLKEKHSELINTHAELLRKNADTAKQLTVTQQSQEEVARVKEQLAFQMEQAKRESEMKMEEQSDQLEKLKRE LAARAGELARAQEALSRTEQSGSELSSRLDTLNAEKEALSGVVRQREAELLAAQSLVREKEEALSQEQQRSSQEKGELRGQLAEKESQEQGLRQKLLDEQLAVLRSAAAEAEAILQDAVSKLDDPLHLRC TSSPDYLVSRAQAALDSVSGLEQGHTQYLASSEDASALVAALTRFSHLAADTIVNGAATSHLAPTDPADRLMDTCRECGARALELVGQLQDQTVLPRAQPSLMRAPLQGILQLGQDLKPKSLDVRQEELG AMVDKEMAATSAAIEDAVRRIEDMMSQARHESSGVKLEVNERILNSCTDLMKAIRLLVMTSTSLQKEIVESGRGAATQQEFYAKNSRWTEGLISASKAVGWGATQLVESADKVVLHMGKYEELIVCSHEI AASTAQLVAASKVKANKNSPHLSRLQECSRTVNERAANVVASTKSGQEQIEDRDTMDFSGLSLIKLKKQEMETQVRVLELEKTLEAERVRLGELRKQHYVLAGGMGTPSEEEPSRPSPAPRSGATKKPPL AQKPSIAPRTDNQLDKKDGVYPAQLVNY

Subcellular Location

Description
Cytoplasm, perinuclear region. Endomembrane system. Cytoplasmic vesicle, clathrin-coated vesicle membrane. Note=Membrane-associated protein, mainly localized at the endocytic compartments and in the perinuclear region.
Position in the Nuclear Envelope
Location	Location ID	Description
Perinuclear Region	SL-0198	The perinuclear region is the cytoplasmic region just around the nucleus.
Membrane Topology
Topology	Source	Annotation Type
Unknown	UniProt	Sequence Analysis
Assigned Ontology terms

Cellular Component	Apical Plasma Membrane (GO:0016324) Cell Cortex (GO:0005938) Clathrin-Coated Pit (GO:0005905) Clathrin-Coated Vesicle (GO:0030136) Clathrin-Coated Vesicle Membrane (GO:0030665) Cytoskeleton (GO:0005856) Cytosol (GO:0005829) Dendrite Cytoplasm (GO:0032839) Dendritic Spine (GO:0043197) Intracellular Membrane-Bounded Organelle (GO:0043231) Membrane (GO:0016020) Mitochondrion (GO:0005739) Neuronal Cell Body (GO:0043025) Perinuclear Region Of Cytoplasm (GO:0048471) Plasma Membrane (GO:0005886) Postsynaptic Density (GO:0014069) Ruffle Membrane (GO:0032587) Synaptic Membrane (GO:0097060)

Biology & Function

Description
Component of clathrin-coated pits and vesicles, that may link the endocytic machinery to the actin cytoskeleton. Binds 3- phosphoinositides (via ENTH domain). May act through the ENTH domain to promote cell survival by stabilizing receptor tyrosine kinases following ligand-induced endocytosis.
Assigned Ontology terms

Biological Process	Actin Filament Organization (GO:0007015) Activation Of Cysteine-Type Endopeptidase Activity Involved In Apoptotic Process (GO:0006919) Apoptotic Process (GO:0006915) Clathrin Coat Assembly (GO:0048268) Digestive System Development (GO:0055123) Endocytosis (GO:0006897) Membrane Organization (GO:0061024) Negative Regulation Of Actin Filament Polymerization (GO:0030837) Negative Regulation Of Apoptotic Process (GO:0043066) Negative Regulation Of Arp2/3 Complex-Mediated Actin Nucleation (GO:0034316) Positive Regulation Of Apoptotic Process (GO:0043065) Positive Regulation Of Clathrin Coat Assembly (GO:1905445) Positive Regulation Of Clathrin-Dependent Endocytosis (GO:2000370) Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway (GO:0045742) Positive Regulation Of Mitochondrial Outer Membrane Permeabilization Involved In Apoptotic Signaling Pathway (GO:1901030) Positive Regulation Of Platelet-Derived Growth Factor Receptor-Beta Signaling Pathway (GO:2000588) Positive Regulation Of Protein Binding (GO:0032092) Protein Stabilization (GO:0050821) Receptor-Mediated Endocytosis (GO:0006898) Regulation Of Actin Cytoskeleton Organization (GO:0032956) Regulation Of Clathrin-Dependent Endocytosis (GO:2000369) Regulation Of Endocytosis (GO:0030100) Regulation Of Gastric Acid Secretion (GO:0060453)
Molecular Function	Actin Binding (GO:0003779) Actin Filament Binding (GO:0051015) Clathrin Adaptor Activity (GO:0035615) Clathrin Binding (GO:0030276) Clathrin Light Chain Binding (GO:0032051) Identical Protein Binding (GO:0042802) Phosphatidylinositol Binding (GO:0035091) Phosphatidylinositol-3,4,5-Trisphosphate Binding (GO:0005547) Phosphatidylinositol-3,4-Bisphosphate Binding (GO:0043325) Phosphatidylinositol-3,5-Bisphosphate Binding (GO:0080025) Phosphatidylinositol-4,5-Bisphosphate Binding (GO:0005546) Protein Heterodimerization Activity (GO:0046982) Protein Homodimerization Activity (GO:0042803) SH3 Domain Binding (GO:0017124)

Protein-Protein Interactions

Interactions with Nuclear Envelope proteins (1 interactors)

Partner (NucEnvDB)		IntAct	Confidence score
Q01279	Epidermal growth factor receptor	EBI-27088765	0.40
Interactions with other proteins (6 interactors)

Partner (UniProt)		IntAct	Confidence score
P04973	Clathrin light chain A (Lca)	EBI-7374625	0.37
P04975	Clathrin light chain B (Lcb)	EBI-7374604	0.57
Q61210	Rho guanine nucleotide exchange factor 1 (Lbc's second cousin) (Lymphoid blast crisis-like 2)	EBI-649779	0.37
Q60598	Src substrate cortactin	EBI-7285203	0.49
Q96B97	SH3 domain-containing kinase-binding protein 1 (CD2-binding protein 3) (CD2BP3) (Cbl-interacting protein of 85 kDa) (Human Src family kinase-binding protein 1) (HSB-1)	EBI-7167363	0.40
G3V6K6	Receptor protein-tyrosine kinase (EC 2.7.10.1)	EBI-27088754	0.52

Cross-References

Database	Links
UNIPROT	Q9JKY5 Q3UJ14
Pfam	PF07651 PF16515 PF01608
PROSITE	PS50942 PS50945

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