NucEnvDB

NucEnvDB

A database of Nuclear Envelope Proteins and their Interactions

Rho GTPase-activating protein 10 - Homo sapiens - NucEnvDB

Rho GTPase-activating protein 10 (Homo sapiens)

FASTA TEXT XML

Subcellular Location Biology & Function Interactions Cross-References

General Information

Protein Information
Protein Name	Rho GTPase-activating protein 10
Accession Code	A1A4S6
Gene	ARHGAP10
Organism	Homo sapiens \| Human (Taxonomy: 9606)
Part of Reference Proteome?	Yes
Sequence (Length: 786)
MGLQPLEFSDCYLDSPWFRERIRAHEAELERTNKFIKELIKDGKNLIAATKSLSVAQRKFAHSLRDFKFEFIGDAVTDDE RCIDASLREFSNFLKNLEEQREIMALSVTETLIKPLEKFRKEQLGAVKEEKKKFDKETEKNYSLIDKHLNLSAKKKDSHL QEADIQVEQNRQHFYELSLEYVCKLQEIQERKKFEFVEPMLSFFQGMFTFYHQGHELAKDFNHYKMELQINIQNTRNRFE GTRSEVEELMNKIRQNPKDHKRASQFTAEGYLYVQEKRPAPFGSSWVKHYCMYRKAAKKFNMIPFEHRSGGKLGDGEVFF LKECTKRHTDSIDRRFCFDIEAADRPGVSLTMQAFSEEERKQWLEALGGKEALSHSFNTAIIPRPEGNAQLDKMGFTIIR KCISAVETRGINDQGLYRVVGVSSKVQRLLSMLMDVKTCNEVDLENSADWEVKTITSALKQYLRSLPEPLMTYELHGDFI VPAKSGSPESRVNAIHFLVHKLPEKNKEMLDILVKHLTNVSNHSKQNLMTVANLGVVFGPTLMRPQEETVAALMDLKFQN IVVEILIENHEKIFRTPPDTTFPEPTCLSASPPNAPPRQSKRQGQRTKRPVAVYNLCLELEDGDNPYPSKEDTPTSSLDS LSSPSPVTTAVPGPPGPDKNHLLADGGSFGDWASTIPGQTRSSMVQWLNPQSPTTTSSNSAVTPLSPGSSPFPFSPPATV ADKPPESIRSRKARAVYPCEAEHSSELSFEIGAIFEDVQTSREPGWLEGTLNGKRGLIPQNYVKLL

Structure Viewer (PDB: 2MIO)

Subcellular Location

Description
Cytoplasm {By Similarity}. Cytoplasm, perinuclear region {By Similarity}. Cell membrane {By Similarity}. Note=Association to cell membrane is dependent on PH domain. {By Similarity}.
Position in the Nuclear Envelope
Location	Location ID	Description
Perinuclear Region	SL-0198	The perinuclear region is the cytoplasmic region just around the nucleus.
Membrane Topology
Topology	Source	Annotation Type
Unknown	UniProt	Sequence Analysis
Assigned Ontology terms

Cellular Component	Cytosol (GO:0005829) Perinuclear Region Of Cytoplasm (GO:0048471) Plasma Membrane (GO:0005886)

Biology & Function

Description
GTPase activator for the small GTPases RhoA and Cdc42 by converting them to an inactive GDP-bound state. Essential for PTKB2 regulation of cytoskeletal organization via Rho family GTPases. Inhibits PAK2 proteolytic fragment PAK-2p34 kinase activity and changes its localization from the nucleus to the perinuclear region. Stabilizes PAK-2p34 thereby increasing stimulation of cell death (By similarity). {By Similarity, Experimental EvidencePubMed:11432776}.
Assigned Ontology terms

Biological Process	Cytoskeleton Organization (GO:0007010) Negative Regulation Of Apoptotic Process (GO:0043066) Regulation Of Small GTPase Mediated Signal Transduction (GO:0051056) Signal Transduction (GO:0007165)
Molecular Function	GTPase Activator Activity (GO:0005096)

Protein-Protein Interactions

Interactions with Nuclear Envelope proteins (2 interactors)

Partner (NucEnvDB)		IntAct	Confidence score
Q14289	Protein-tyrosine kinase 2-beta	EBI-28941112	0.35
Q6P5Z2	Serine/threonine-protein kinase N3	EBI-1390955	0.68
Interactions with other proteins (11 interactors)

Partner (UniProt)		IntAct	Confidence score
P78314	SH3 domain-binding protein 2 (3BP-2)	EBI-10692719	0.49
Q92625	Ankyrin repeat and SAM domain-containing protein 1A (Odin)	EBI-10697254	0.37
Q9C009	Forkhead box protein Q1 (HNF-3/forkhead-like protein 1) (HFH-1) (Hepatocyte nuclear factor 3 forkhead homolog 1)	EBI-11321694	0.35
Q9UNA1	Rho GTPase-activating protein 26 (GTPase regulator associated with focal adhesion kinase) (Oligophrenin-1-like protein) (Rho-type GTPase-activating protein 26)	EBI-11898726	0.00
Q9ULB1	Neurexin-1 (Neurexin I-alpha) (Neurexin-1-alpha)	EBI-11898717	0.00
Q9Y426	C2 domain-containing protein 2 (Transmembrane protein 24-like)	EBI-21517999	0.35
C9J6V4	Rho GTPase-activating protein 26	EBI-21517948	0.35
P46013	Proliferation marker protein Ki-67 (Antigen identified by monoclonal antibody Ki-67) (Antigen KI-67) (Antigen Ki67)	EBI-20562326	0.35
Q02539	Histone H1.1 (Histone H1a)	EBI-20937220	0.40
P03372	Estrogen receptor (ER) (ER-alpha) (Estradiol receptor) (Nuclear receptor subfamily 3 group A member 1)	EBI-21302175	0.35
Q05209	Tyrosine-protein phosphatase non-receptor type 12 (EC 3.1.3.48) (PTP-PEST) (Protein-tyrosine phosphatase G1) (PTPG1)	EBI-27116319	0.27

Cross-References

Database	Links
UNIPROT	A1A4S6 A1L0S5 Q2VPC4 Q2VPC5 Q96EV3 Q96S75
PDB	2MIO
Pfam	PF00169 PF00620 PF14604
PROSITE	PS50003 PS50238 PS50002
OMIM	609746
DisGeNET	79658

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