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A database of Nuclear Envelope Proteins and their Interactions
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Tyrosine 3-monooxygenase - Caenorhabditis briggsae - NucEnvDB
Tyrosine 3-monooxygenase (
Caenorhabditis briggsae
)
FASTA
TEXT
XML
Subcellular Location
Biology & Function
Cross-References
General Information
Protein Information
Protein Name
Tyrosine 3-monooxygenase
Accession Code
A8X3V8
Gene
cat
Organism
Caenorhabditis briggsae
(Taxonomy:
6238
)
Part of Reference Proteome?
Yes
Sequence (Length: 517)
Show
MSSLTNPTTVMEEEEVPVAAPIRRGNKNPRRYSLVHQASCETQHHIGIRRQNTIQHRKQLTDQMREQKILQQLNDEGVEVIFAANDVSSIDFSVIVTSTDYISTFVSDILYNMKSAGVQICHVETRESKA
VSGHDVLLDCRATKNQLIKAAELLTQNHVALTHFSIFSKKSVEKSQSMIWFPRHISELDQCSKCITKYEPTTDPRHPGHGDDEYIARRKFLNDQALEFKFGDEIGYVEYTEDEHATWKAVYEKLGGLHES
HTCSVYRQNLKILQKEKVLTADRIPQIRDVNKFLQKKTGFELRPCSGLLSARDFLASLAFRVFQTTTYLRHHKSPHHSPEPDLIHELLGHVPMFSDPLLAQMSQDIGLMSLGASDEHIEKLATVYWFIVE
FGLCKEDGKLKAIGAGLLSAYGELIHACSDAPEHKDFDPAVTAIQKYEDDDYQPLYFVADSIHDALAKLRKYASSMDRPFSVVYDPFTKSIETIQSSADLEKAFSRLSNDLSAITHAADRMKISITA
Subcellular Location
Description
Show
Cytoplasm, perinuclear region {
By Similarity
UniProtKB:P24529
}. Cell projection, axon {
By Similarity
UniProtKB:P24529
}. Note=Expressed in dopaminergic axons and axon terminals. {
By Similarity
UniProtKB:P24529
}.
Position in the Nuclear Envelope
Location
Location ID
Description
Perinuclear Region
SL-0198
The perinuclear region is the cytoplasmic region just around the nucleus.
Membrane Topology
Topology
Source
Annotation Type
Unknown
UniProt
Sequence Analysis
Assigned Ontology terms
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Cellular Component
Axon
(
GO:0030424
)
Cytoplasm
(
GO:0005737
)
Perikaryon
(
GO:0043204
)
Perinuclear Region Of Cytoplasm
(
GO:0048471
)
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Biology & Function
Description
Hide
Involved in the synthesis of catecholamines, such as dopamine. Has a role in serotonin signaling. Required for normal explorative and foraging behavior (By similarity). {
By Similarity
UniProtKB:P90986
}.
Assigned Ontology terms
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Biological Process
Behavior
(
GO:0007610
)
Dopamine Biosynthetic Process From Tyrosine
(
GO:0006585
)
Neurotransmitter Biosynthetic Process
(
GO:0042136
)
Molecular Function
Iron Ion Binding
(
GO:0005506
)
Tyrosine 3-Monooxygenase Activity
(
GO:0004511
)
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Cross-References
Database
Links
UNIPROT
A8X3V8
Pfam
PF00351
PROSITE
PS00367
PS51410
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National and Kapodistrian University of Athens
Department of Biology
Biophysics & Bioinformatics Laboratory