NucEnvDB

NucEnvDB

A database of Nuclear Envelope Proteins and their Interactions

Obscurin-like protein 1 - Mus musculus - NucEnvDB

Obscurin-like protein 1 (Mus musculus)

FASTA TEXT XML

Subcellular Location Biology & Function Cross-References

General Information

Protein Information
Protein Name	Obscurin-like protein 1
Accession Code	D3YYU8
Gene	Obsl1
Organism	Mus musculus \| House mouse (Taxonomy: 10090)
Part of Reference Proteome?	Yes
Sequence (Length: 1804)
MKAGSGDQGSPPCFLRFPRPVRVVSGAEAELKCVVLGEPPPTVVWEKGGQQLVASERLSFPEDGAEHGLLLSGALPTDAGVYVCRARNAAGEAYAAAAVTVLEPPAPEPEPESSECPLPTPGTGEGAPKF LTGPQSQWVLRGEEVVLTCQVGGLPEPKLYWEKDGMALDEVWDSSHFKLEPGRGASDEGASLTLRILAARLPDSGVYVCHARNAHGHAQAGALLQVHQPRESPPQDPDENPKPVLEPLKGAPKTFWVNEG KHAKFRCYVMGKPEPEIEWHLEGRPLLPDRRRLMYRDRDGGFVLKVLYCQAKDRGLYVCAARNSAGQTLSAVQLHVKEPRLRFTRPLQDVEGREHGIVVLECKVPNSRIPTAWFREDQRLLPCRKYEQIE EGAVRRLVIHKLKADDDGVYLCEMRGRVRTVANVTVKGPILKRLPRKLDVLEGENAVLLVETQEAGVQGCWSRDGEDLPDTCQSSCGHMHALVLPGVTREDAGEITFSLGNSRTTTLLRVKCVKHSPPGP PVMVEMFKGQKNKVLLTWKPPEPPPETSFIYRLERQEVGSDDWIQCFSIEKAGAVEVPGDCVPTEGDYHFRICTVSEHGRSPHVVFNGSAHLVPTARLVSGLEDVQVYDGEDAVFSLDLSAIIQGSWFLN GEQLQSNEPEGQVEPGALRYRIEQKGLQHRLILQAVKHRDSGALVGFSCPGVQDSAALTIQESSVHILSPQDKVSLTFTTSERVVLTCELSRVDFPATWYKDGQKVEESESLIVKTEGRKHRLILPEAQV RDSGEFECRTEGVSAFFGVTVQDPPVHIVNPQEHVFVHAITSECVRLTCEVDREDTTVHWYKDGQEVEESDIIVLENKGPHHRLVLPAARPSDGGEFQCVAGDERAYFTVTITDVFSWIVYPSSEVHVAA VRLERVVLTCELCRPWAEVRWTKDGEEVVESPALLLEKEDTIRRLVLPSVQLEDSGEYLCEIHDESASFTITVTEPPVRIIYPQDEVTLHAVSLECVVLTCELSREDAPVRWYKDGLEVEESEALVLQSD GPRRRLVLPAAQPEDGGEFVCDAGDDSAFFTVTVTAPPERIVHPAARSLDLQFGAPGHVELRCEVAPAGSQVRWYKDGLEVEVSDALQLGAEGPARTLTLPHAQPEDAGEYVCETRDEAVTFNVSLAELP VQFLAPEAAPNPLCVVPGEPVVLSCELSRASAQVFWSHNGSPVQQGEGLELRAEGPRRILCIQAADLAHTGVYTCQSGASPGAPSLSFNVQVAELPPVKLVSELTPLTVHEGDDATFQCEVSPPDAEVTW LRNGAVITAGPQLEMVQNGSSRTLIIRGCQLKDAGTVTARAGAADTSARLHVRETELLFLRRLQDVRAEEGQDVHLEVETGRVGAAGTVRWIRGGEPLPLDSRLTTAQDGHVHRLSIHGVLLTDQGTYGC ESRHDRTLARLSVRPRQLRELRPLEDVTVHEGGSATFQLELSQEGVTGEWAQGGVRLHPGPKCHIQSEGRTHRLVLSGLGLADSGCVSFTADTLRCAARLTVREVPVTIVQGPQDLEVTEGDTATFECEL SQTLADVIWEKDGQALSLSPRLRLQALGTRRLLLLRRCCSSDAGTYSCVVGTARSEPARLTVREREVSVLRELRSVSAREGDGATFECTVSETEITGRWELGGRALRPGGRVRIRQEGKKHILVLSELRT EDTGEVCFQAGPAQSLARLEVEALPLQMCRRPPREKTVLVNRRAVLEVTVSRPGGHVCWMREGVELCPGNKYETRRHGTTHSLVIHDVRPEDQGTYSCQAGQDSADTQLLVDGD

Subcellular Location

Description
Cytoplasm {By SimilarityUniProtKB:O75147}. Cytoplasm, perinuclear region {By SimilarityUniProtKB:O75147}. Golgi apparatus {By SimilarityUniProtKB:O75147}. Note=Colocalizes with CUL7 at the Golgi apparatus in neurons. {By SimilarityUniProtKB:O75147}.
Position in the Nuclear Envelope
Location	Location ID	Description
Perinuclear Region	SL-0198	The perinuclear region is the cytoplasmic region just around the nucleus.
Membrane Topology
Topology	Source	Annotation Type
Unknown	UniProt	Sequence Analysis
Assigned Ontology terms

Cellular Component	3M Complex (GO:1990393) Centrosome (GO:0005813) Cytoplasm (GO:0005737) Golgi Apparatus (GO:0005794) Perinuclear Region Of Cytoplasm (GO:0048471) Synapse (GO:0045202)

Biology & Function

Description
Core component of the 3M complex, a complex required to regulate microtubule dynamics and genome integrity. It is unclear how the 3M complex regulates microtubules, it could act by controlling the level of a microtubule stabilizer. Acts as a regulator of the Cul7- RING(FBXW8) ubiquitin-protein ligase, playing a critical role in the ubiquitin ligase pathway that regulates Golgi morphogenesis and dendrite patterning in brain. Required to localize CUL7 to the Golgi apparatus in neurons (By similarity). {By Similarity}.
Assigned Ontology terms

Biological Process	Golgi Organization (GO:0007030) Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules (GO:0007156) Microtubule Cytoskeleton Organization (GO:0000226) Positive Regulation Of Dendrite Morphogenesis (GO:0050775) Protein Localization To Golgi Apparatus (GO:0034067) Regulation Of Mitotic Nuclear Division (GO:0007088) Retina Layer Formation (GO:0010842) Synapse Assembly (GO:0007416)
Molecular Function

Cross-References

Database	Links
UNIPROT	D3YYU8 F7AD47 Q80WA6
Pfam	PF07679
PROSITE	PS50853 PS50835

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