NucEnvDB

NucEnvDB

A database of Nuclear Envelope Proteins and their Interactions

Coiled-coil domain-containing protein 78 - Mus musculus - NucEnvDB

Coiled-coil domain-containing protein 78 (Mus musculus)

FASTA TEXT XML

Subcellular Location Biology & Function Cross-References

General Information

Protein Information
Protein Name	Coiled-coil domain-containing protein 78
Accession Code	D3Z5T1
Gene	Ccdc78
Organism	Mus musculus \| House mouse (Taxonomy: 10090)
Part of Reference Proteome?	Yes
Sequence (Length: 437)
MDQRPELLSSMEYVASPDPKPGVPLRVAENVAPGAEDWLPSASGHLAWATSLETEHQTHLELSEEQRLQISKELVDLQIATHHLREQHEAEVFELRREILRLESRVLELELHGNGACQGHKVQPMANLGQ HQVPPLEPPGGQQKLQEELKWLLEHHRARQQALETQVGVLSQQLQGAREEARTTGQQLASQAMVLASCKGQLRQAEAENTQLQLQLKKMNEEYAVRLQHYARETVENASSTNQAALQAFLESTLQDIRAA HRTREQQLAQAARTYRKRLADLNQRQELLLTTCRATFATAINLEPLPMHWATELSHPRENEYGRHRTLLLYPEKGSGETSKENKSQPLALDTASWAQIQQRLQDFSQDTQAELERERAQLMVRATMAEQQ LSELQEYVDQHLGRYKQEILKLRKLVNIGDPQGVEAVSSPGSGGARL

Subcellular Location

Description
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {By Similarity}. Cytoplasm, perinuclear region {By Similarity}. Cell membrane, sarcolemma {By Similarity}. Sarcoplasmic reticulum {By Similarity}. Note=Localizes to centrioles and deuterosome. Found primarily in the perinuclear region as well as along the sarcolemmal membrane and in reticular pattern within the sarcoplasm (By similarity). {By Similarity}.
Position in the Nuclear Envelope
Location	Location ID	Description
Perinuclear Region	SL-0198	The perinuclear region is the cytoplasmic region just around the nucleus.
Membrane Topology
Topology	Source	Annotation Type
Unknown	UniProt	Sequence Analysis
Assigned Ontology terms

Cellular Component	Centriole (GO:0005814) Cytoplasm (GO:0005737) Deuterosome (GO:0098536) Perinuclear Region Of Cytoplasm (GO:0048471) Sarcolemma (GO:0042383) Sarcoplasmic Reticulum (GO:0016529)

Biology & Function

Description
Component of the deuterosome, a structure that promotes de novo centriole amplification in multiciliated cells that can generate more than 100 centrioles. Deuterosome-mediated centriole amplification occurs in terminally differentiated multiciliated cells (G1/0) and not in S phase. Essential for centriole amplification and is required for CEP152 localization to the deuterosome (By similarity). {By Similarity}.
Assigned Ontology terms

Biological Process	Cell Projection Organization (GO:0030030) De Novo Centriole Assembly Involved In Multi-Ciliated Epithelial Cell Differentiation (GO:0098535) Skeletal Muscle Contraction (GO:0003009)
Molecular Function

Cross-References

Database	Links
UNIPROT	D3Z5T1
Pfam	PF14739

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