NucEnvDB

NucEnvDB

A database of Nuclear Envelope Proteins and their Interactions

Kinesin-like protein KIF1A - Rattus norvegicus - NucEnvDB

Kinesin-like protein KIF1A (Rattus norvegicus)

FASTA TEXT XML

Subcellular Location Biology & Function Interactions Cross-References

General Information

Protein Information
Protein Name	Kinesin-like protein KIF1A
Accession Code	F1M4A4
Gene	Kif1a
Organism	Rattus norvegicus \| Norway rat (Taxonomy: 10116)
Part of Reference Proteome?	Yes
Sequence (Length: 1707)
MAGASVKVAVRVRPFNSREMSRDSKCIIQMSGSTTTIVNPKQPKETPKSFSFDYSYWSHTSPEDINYASQKQVYRDIGEEMLQHAFEGYNVCIFAYGQTGAGKSYTMMGKQEKDQQGIIPQLCEDLFSRI NDTTNDNMSYSVEVSYMEIYCERVRDLLNPKNKGNLRVREHPLLGPYVEDLSKLAVTSYNDIQDLMDSGNKARTVAATNMNETSSRSHAVFNIIFTQKRHDAETNITTEKVSKISLVDLAGSERADSTGA KGTRLKEGANINKSLTTLGKVISALAEMDSGPNKNKKKKKTDFIPYRDSVLTWLLRENLGGNSRTAMVAALSPADINYDETLSTLRYADRAKQIRCNAIINEDPNNKLIRELKDEVTRLRDLLYAQGLGD ITDTNTVPGGPKLTNALVGMSPSSSLSALSSRAASVSSLHERILFAPGSEEAIERLKETEKIIAELNETWEEKLRRTEAIRMEREALLAEMGVAMREDGGTLGVFSPKKTPHLVNLNEDPLMSECLLYYI KDGVTRVGREDAERRQDIVLSGHFIKEEHCIFRSDSRGGGEAVVTLEPCEGADTYVNGKKVTEPSILRSGNRIIMGKSHVFRFNHPEQARQERERTPCAETPAEPVDWAFAQRELLEKQGIDMKQEMEQR LQELEDQYRREREEATYLLEQQRLDYESKLEALQKQMDSRYYPEVNEEEEEPEDEVQWTERECELALWAFRKWKWYQFTSLRDLLWGNAIFLKEANAISVELKKKVQFQFVLLTDTLYSPLPPDLLPPEA AKDRETRPFPRTIVAVEVQDQKNGATHYWTLEKLRQRLDLMREMYDRAAEVPSSVVEDCDNVVTGGDPFYDRFPWFRLVGRAFVYLSNLLYPVPLVHRVAIVSEKGEVKGFLRVAVQAISADEEAPDYGS GVRQSGTAKISFDDQHFEKFQSESCPVVGMSRSGTSQEELRIVEGQGQGADAGPSADEVNNNTCSAVPPEGLLDSPEKAALDGPLDTALDHLRLGSTFTFRVTVLQASSISAEYADIFCQFNFIHRHDEA FSTEPLKNTGRGPPLGFYHVQNIAVEVTKSFIEYIKSQPIVFEVFGHYQQHPFPPLCKDVLSPLRPSRRHFPRVMPLSKPVPATKLSTMTRPSPGPCHCKYDLLVYFEICELEANGDYIPAVVDHRGGMP CMGTFLLHQGIQRRITVTLLHETGSHIRWKEVRELVVGRIRNTPETDEALIDPNILSLNILSSGYVHPAQDDRQFLDSDIPRTFYQFEAAWDSSMHNSLLLNRVTPYREKIYMTLSAYIEMENCTQPAVI TKDFCMVFYSRDAKLPASRSIRNLFGSGSLRATEGNRVTGVYELSLCHVADAGSPGMQRRRRRVLDTSVAYVRGEENLAGWRPRSDSLILDHQWELEKLSLLQEVEKTRHYLLLREKLETTQRPVPEVLS PASSEDSESRSSSGASSPLSAEGQPSPLEVPNERQRELAVKCLRLLMHTFNREYTHSHVCISASESKLSEMSVTLMRDPSMSPLGAATLTPSSTCPSLIEGRYGATDVRTPQPCSRPASPEPELLPELDS KKTPSPVRATETEKEPQRLLVPDIQEIRVSPIVSKKGYLHFLEPHTAGWAKRFVVVRRPYAYMYNSDKDTVERFVLNLSTAQVEYSEDQQAMLKTPNTFAVCTEHRGILLQANSDKDMHDWLYAFNPLLA GTIRSKLSRRRSAQMRV

Subcellular Location

Description
Cytoplasm, cytoskeleton {By SimilarityUniProtKB:Q12756}. Cell projection, neuron projection {By SimilarityUniProtKB:Q12756}. Cell projection, axon {By SimilarityUniProtKB:P33173}. Cytoplasm, perinuclear region {By SimilarityUniProtKB:P33173}. Synapse {By SimilarityUniProtKB:P33173}. Cytoplasmic vesicle, secretory vesicle, neuronal dense core vesicle membrane {ECO:0000269\|PubMed:29166604, ECO:0000269\|PubMed:30021165}; Peripheral membrane protein {ECO:0000305\|PubMed:30021165}; Cytoplasmic side {ECO:0000305\|PubMed:30021165}. Note=Within neuronal cells concentrated in the axon, with smaller amounts in the perinuclear and synaptic regions (By similarity). Expressed in distal regions of neurites. {By SimilarityUniProtKB:P33173, By SimilarityUniProtKB:Q12756}.
Position in the Nuclear Envelope
Location	Location ID	Description
Perinuclear Region	SL-0198	The perinuclear region is the cytoplasmic region just around the nucleus.
Membrane Topology
Topology	Source	Annotation Type
Peripheral	UniProt	Curator Inference {ECO:0000305\|PubMed:30021165}
Assigned Ontology terms

Cellular Component	Anchoring Junction (GO:0070161) Axon (GO:0030424) Axon Cytoplasm (GO:1904115) Cytosol (GO:0005829) Dendrite (GO:0030425) Extrinsic Component Of Neuronal Dense Core Vesicle Membrane (GO:0098674) Kinesin Complex (GO:0005871) Microtubule (GO:0005874) Neuron Projection (GO:0043005) Neuronal Cell Body (GO:0043025) Neuronal Dense Core Vesicle (GO:0098992) Perinuclear Region Of Cytoplasm (GO:0048471) Postsynapse (GO:0098794) Presynapse (GO:0098793) Protein-Containing Complex (GO:0032991) Synaptic Vesicle (GO:0008021)

Biology & Function

Description
Motor for anterograde axonal transport of synaptic vesicle precursors (Probable). Also required for neuronal dense core vesicles (DCVs) transport to the dendritic spines and axons (PubMed:29166604, PubMed:30021165). The interaction calcium-dependent with CALM1 increases vesicle motility and interaction with the scaffolding proteins PPFIA2 and TANC2 recruits DCVs to synaptic sites (PubMed:30021165). {Experimental EvidencePubMed:29166604, Experimental EvidencePubMed:30021165, Curator Inference}.
Assigned Ontology terms

Biological Process	Anterograde Axonal Transport (GO:0008089) Anterograde Neuronal Dense Core Vesicle Transport (GO:1990048) Cytoskeleton-Dependent Intracellular Transport (GO:0030705) Dense Core Granule Cytoskeletal Transport (GO:0099519) Interkinetic Nuclear Migration (GO:0022027) Microtubule-Based Movement (GO:0007018) Protein Transport Along Microtubule (GO:0098840) Regulation Of Dendritic Spine Development (GO:0060998) Regulation Of Dendritic Spine Morphogenesis (GO:0061001) Retrograde Neuronal Dense Core Vesicle Transport (GO:1990049) Vesicle-Mediated Transport (GO:0016192)
Molecular Function	ATP Binding (GO:0005524) ATP Hydrolysis Activity (GO:0016887) Identical Protein Binding (GO:0042802) Microtubule Binding (GO:0008017) Microtubule Motor Activity (GO:0003777) Plus-End-Directed Microtubule Motor Activity (GO:0008574)

Protein-Protein Interactions

Interactions with other proteins (1 interactors)

Partner (UniProt)		IntAct	Confidence score
A0A142I9X8	11 kDa protein (Membrane protein US9) (Tegument protein US9)	EBI-11701393	0.50

Cross-References

Database	Links
UNIPROT	F1M4A4
Pfam	PF12473 PF00498 PF12423 PF00225 PF16183 PF00169
PROSITE	PS50006 PS00411 PS50067 PS50003

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