The nuclear envelope is a membrane system which surrounds the nucleoplasm of eukaryotic cells. It is composed of the nuclear lamina, nuclear pore complexes and two nuclear membranes. The space between the two membranes is called the nuclear intermembrane space.
GTPase activator for RAN, converting it to the GDP-bound state (PubMed:9108047). Converts cytoplasmic GTP-bound RAN to GDP-bound RAN, which is required for RAN-mediated nuclear import and export (By similarity). {By
SimilarityUniProtKB:P46060, Experimental EvidencePubMed:9108047}.
National and Kapodistrian University of Athens
Department of Biology
Biophysics & Bioinformatics Laboratory