NucEnvDB

NucEnvDB

A database of Nuclear Envelope Proteins and their Interactions

Ras GTPase-activating-like protein rng2 - Schizosaccharomyces pombe 972h- - NucEnvDB

Ras GTPase-activating-like protein rng2 (Schizosaccharomyces pombe 972h-)

FASTA TEXT XML

Subcellular Location Biology & Function Interactions Cross-References

General Information

Protein Information
Protein Name	Ras GTPase-activating-like protein rng2
Accession Code	O14188
Gene	rng2
Organism	Schizosaccharomyces pombe 972h- (Taxonomy: 284812)
Part of Reference Proteome?	Yes
Sequence (Length: 1489)
MDVNVGLSRLQSQAGAPVGTKGSNTRLAAKQRETLQAYDYLCRVDEAKKWIEECLGTDLGPTSTFEQSLRNGVVLALLVQ KFQPDKLIKIFYSNELQFRHSDNINKFLDFIHGIGLPEIFHFELTDIYEGKNLPKVIYCIHALSYFLSMQDLAPPLIKSD ENLSFTDEDVSIIVRRLRQSNVILPNFKALSADFMLRASPVSSRTPSPTRFPKHARFQTLNSSDSASIYSSPYTSPTLEF SKKDASARSDILKMHRRTKSATPSLEQFNEPYKQTLPSHSIEFEDSFFQPPSQKGHMQRSFLTTFSAPTRRREALFSTTS GLSQRSPVDEKIVNAIQACGRGVLVRLRLVDMLQSLVEQSSSVVLLQAVIRGYISRNTYRIRKKAYDELVNWVTSIQSIS RAYLIRAQYRKVVLQEEATKSIQTLQSIIRGGFYRRKYHSLIERLDLFTPSFVLIQSSALGFLTRHAIVNMLDNLYNYIP LFNRMQSILRANMFRNEWSNFLDSVQSFPVSFHSICKGRLIRDSINRLNGSLLGELDNFIKLQNLSRGFMIRRAFKEKLE KLKASTSSFIALQAIVRAFLLRKNLESIYDSFQKSHLSVIKAQSLYRGFITRTKIDYCNDYLLKRLPDIVFMQSAVRAIL LRDDVNYTEVQLDSFIPEIVLLQSLIRGYLSRNKFSRKLQNFHKNMENPIVAKSIFRGRQEGLAYRELATAKNPPVMTVK NFVHLLDDTNFDFEEEVLLEKMRKEIVQQVRDNEEIEVHINELDVKIALLVKNKISLDDVLKHHNKYKFGKQSTEYLKIN TLSMKSLNNSSRKFLELYQCFFYVLQTNEMYLANYFQALKTEGTSSVKIRHAVYLVLQIFGHGSNRREEVLLLRFISQVI KLEAALVNSSQDLLSDDCVWKLLFTGYRGDVREVKLWKTILGRIHKVLVADNHLDFEINPLTLFKSFNPEVASQTDSPKL TLSLAMQHPPTRNLYVSRLRELRKLCQSFLVALSKNIENIPYALCYTAAQLKNSLQRYFPAAHKEEIFGVIGKFVYWAYV APVLVSPDNFKLVDGSITALQRKNLYTLSSILSEIFSIESCDSKQLGFFRPLSEFIEVSKQDTMLMLERLVDVVDPEVYF EFDAFEDLVNTKRPVIYMKRDDILGIYSSIAYVIDSIAPPDVNDPLRAVVNSLGPVSEQDNDFVQDETDVKLELNPKFCT IENPVAQERTLIVQTKRYILFIIRIQNGLNLLEILVKPVTDSDEAAWQNLLAEESEKNARNYDLFDDSIFSMSFAELKYT ALSNIVEMEKLGFANRRNNYQDMVNSIALDIRNKSRRRMQRQRELDAGHQSLLNLREKRAFLDSQLKSYNEYIEQAMETL QSKKGKKKLIPFSKQYFHMRDLRKSGRVPRFGSFKYPALKLYDRGVLVSISHMPQKEKLYITISADEVGKFILEATSPTV KVSSPRCELHLDDLLSAQYNKVLTLDVLDGRLKLNTNMFLHLIFSKFYS

Structure Viewer (PDB: 1P2X)

Subcellular Location

Description
Cytoplasm, cytoskeleton. Nucleus envelope. Cytoplasm, cytoskeleton, microtubule organizing center, spindle pole body. Note=Localized to the F-actin ring and spindle pole body during interphase and mitosis. Also found in septum.
Position in the Nuclear Envelope
Location	Location ID	Description
Nuclear Envelope	SL-0178	The nuclear envelope is a membrane system which surrounds the nucleoplasm of eukaryotic cells. It is composed of the nuclear lamina, nuclear pore complexes and two nuclear membranes. The space between the two membranes is called the nuclear intermembrane space.
Membrane Topology
Topology	Source	Annotation Type
Unknown	UniProt	Sequence Analysis
Assigned Ontology terms

Cellular Component	Cytoplasm (GO:0005737) Medial Cortical Node (GO:0071341) Mitotic Actomyosin Contractile Ring (GO:0110085) Mitotic Actomyosin Contractile Ring, Proximal Layer (GO:0120104) Mitotic Spindle Pole Body (GO:0044732) Nuclear Envelope (GO:0005635) Spindle Pole Body (GO:0005816)

Biology & Function

Description
Required for cytokinesis. Component of the contractile F- actin ring; required for its construction following assembly of F-actin at the division site. {Experimental EvidencePubMed:9635188}.
Assigned Ontology terms

Biological Process	Actin Filament Bundle Convergence Involved In Mitotic Contractile Ring Assembly (GO:1903478) Division Septum Assembly (GO:0000917) Establishment Of Mitotic Actomyosin Contractile Ring Localization (GO:1903486) Mitotic Actomyosin Contractile Ring Assembly (GO:1903475) Mitotic Actomyosin Contractile Ring Assembly Actin Filament Organization (GO:1903479) Mitotic Actomyosin Contractile Ring Contraction (GO:1902404) Mitotic Actomyosin Contractile Ring Maintenance (GO:1902406) Regulation Of Actin Cytoskeleton Organization (GO:0032956) Regulation Of GTPase Activity (GO:0043087) Signal Transduction (GO:0007165)
Molecular Function	Actin Filament Binding (GO:0051015) Calmodulin Binding (GO:0005516) Cytoskeletal Anchor Activity (GO:0008093) GTPase Activator Activity (GO:0005096)

Protein-Protein Interactions

Interactions with other proteins (2 interactors)

Partner (UniProt)		IntAct	Confidence score
P05933	Calmodulin (CaM)	EBI-1152509	0.52
P10989	Actin (EC 3.6.4.-)	EBI-7190604	0.49

Cross-References

Database	Links
UNIPROT	O14188 Q9USG0
PDB	1P2X 1P5S
Pfam	PF00307 PF00612 PF00616 PF03836
PROSITE	PS50021 PS50096 PS50018

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