NucEnvDB

NucEnvDB

A database of Nuclear Envelope Proteins and their Interactions

Dexamethasone-induced Ras-related protein 1 - Mus musculus - NucEnvDB

Dexamethasone-induced Ras-related protein 1 (Mus musculus)

FASTA TEXT XML

Subcellular Location Biology & Function Interactions Cross-References

General Information

Protein Information
Protein Name	Dexamethasone-induced Ras-related protein 1
Accession Code	O35626
Gene	Rasd1
Organism	Mus musculus \| House mouse (Taxonomy: 10090)
Part of Reference Proteome?	Yes
Sequence (Length: 280)
MKLAAMIKKMCPSDSELSIPAKNCYRMVILGSSKVGKTAIVSRFLTGRFEDAYTPTIEDFHRKFYSIRGEVYQLDILDTSGNHPFPAMRRLSILTGDVFILVFSLDNRDSFEEVQRLKQQILDTKSCLKN KTKENVDVPLVICGNKGDRDFYREVEQREIEQLVGDDPQRCAYFEISAKKNSSLDQMFRALFAMAKLPSEMSPDLHRKVSVQYCDVLHKKALRNKKLLRAGSGGGGDHGDAFGILAPFARRPSVHSDLMY IREKTSVGSQAKDKERCVIS

Subcellular Location

Description
Cell membrane {Curator Inference}; Lipid-anchor {Curator Inference}; Cytoplasmic side {Curator Inference}. Cytoplasm, perinuclear region {ECO:0000250}. Nucleus {ECO:0000250}.
Position in the Nuclear Envelope
Location	Location ID	Description
Perinuclear Region	SL-0198	The perinuclear region is the cytoplasmic region just around the nucleus.
Membrane Topology
Topology	Source	Annotation Type
Lipid-Anchored	UniProt	By Similarity {ECO:0000250}
Assigned Ontology terms

Cellular Component	Cytoplasm (GO:0005737) Nucleus (GO:0005634) Perinuclear Region Of Cytoplasm (GO:0048471) Plasma Membrane (GO:0005886) Sarcoplasmic Reticulum (GO:0016529)

Biology & Function

Description
Small GTPase. Negatively regulates the transcription regulation activity of the APBB1/FE65-APP complex via its interaction with APBB1/FE65 (By similarity). {By Similarity}.
Assigned Ontology terms

Biological Process	Negative Regulation Of DNA-Templated Transcription (GO:0045892) Nitric Oxide Mediated Signal Transduction (GO:0007263) Signal Transduction (GO:0007165)
Molecular Function	G-Protein Beta-Subunit Binding (GO:0031681) GTP Binding (GO:0005525) GTPase Activity (GO:0003924)

Protein-Protein Interactions

Interactions with Nuclear Envelope proteins (2 interactors)

Partner (NucEnvDB)		IntAct	Confidence score
Q8CG79	Apoptosis-stimulating of p53 protein 2	EBI-4325310	0.37
Q9JJ00	Phospholipid scramblase 1	EBI-4325299	0.37
Interactions with other proteins (6 interactors)

Partner (UniProt)		IntAct	Confidence score
P43136	Nuclear receptor subfamily 2 group F member 6 (COUP transcription factor 3) (COUP-TF3) (V-erbA-related protein 2) (EAR-2)	EBI-4319978	0.64
P27790	Major centromere autoantigen B (Centromere protein B) (CENP-B)	EBI-4325272	0.37
P62874	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 (Transducin beta chain 1)	EBI-4325276	0.37
Q62420	Endophilin-A1 (Endophilin-1) (SH3 domain protein 2A) (SH3 domain-containing GRB2-like protein 2) (SH3p4)	EBI-4325302	0.37
Q920B9	FACT complex subunit SPT16 (Chromatin-specific transcription elongation factor 140 kDa subunit) (FACT 140 kDa subunit) (FACTp140) (Facilitates chromatin transcription complex subunit SPT16)	EBI-4325306	0.37
P68510	14-3-3 protein eta	EBI-4325314	0.37

Cross-References

Database	Links
UNIPROT	O35626
Pfam	PF00071
PROSITE	PS51421

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