NucEnvDB

NucEnvDB

A database of Nuclear Envelope Proteins and their Interactions

Tyrosine 3-monooxygenase - Anguilla anguilla - NucEnvDB

Tyrosine 3-monooxygenase (Anguilla anguilla)

FASTA TEXT XML

Subcellular Location Biology & Function Cross-References

General Information

Protein Information
Protein Name	Tyrosine 3-monooxygenase
Accession Code	O42091
Gene	th
Organism	Anguilla anguilla \| European eel (Taxonomy: 7936)
Part of Reference Proteome?	No
Sequence (Length: 488)
MPISNSSGSSTKSITRAGSELDRADSITSPRFVGRRQSLIEDARKEREAAAAAESSEASEQIVFDEEDGKALLNLFFTLRSSKIPALSRALKVFETFEAKIHHLETRTRRKPKDSLEDLEYFVRCEVHLA DVSTLISSIRRIAEDVRTTKEVKFHWFPKKISELDSCHHLVTKFDPDLDQDHPGFTDPVYRQRRRMIGEIAFRYKHGEPIPRVEYTEEEIGTWREVYSTLRDLYTTHACSEHLEAFRLLERHCGYSPNSI PQLEDVSHFLKERTGFQLRPVAGLLSARDFLASLAFRVFQCTQYIRHASSPMHSPEPDCVHELLGHVPMLADRTFAQFSQNIGLASLGASEEDIEKLSTLYWFTVEFGLCKQGDGVKAYGAGLLSSYGEL VHSLSDEPERREFDPEAAAAEPYQDQNYQSVYFVSESFTDAKEKLRVYAAGINRPFSVRFDPYTYSIEVLDNPLKIRGGLESVKDELKVLTDALNVLA

Subcellular Location

Description
Cytoplasm, perinuclear region {By SimilarityUniProtKB:P24529}. Cell projection, axon {By SimilarityUniProtKB:P24529}. Note=Expressed in dopaminergic axons and axon terminals. {By SimilarityUniProtKB:P24529}.
Position in the Nuclear Envelope
Location	Location ID	Description
Perinuclear Region	SL-0198	The perinuclear region is the cytoplasmic region just around the nucleus.
Membrane Topology
Topology	Source	Annotation Type
Unknown	UniProt	Sequence Analysis
Assigned Ontology terms

Cellular Component	Axon (GO:0030424) Perinuclear Region Of Cytoplasm (GO:0048471)

Biology & Function

Description
Plays an important role in the physiology of adrenergic neurons. {By Similarity}.
Assigned Ontology terms

Biological Process	Aromatic Amino Acid Metabolic Process (GO:0009072) Dopamine Biosynthetic Process (GO:0042416) Neurotransmitter Biosynthetic Process (GO:0042136)
Molecular Function	Iron Ion Binding (GO:0005506) Tyrosine 3-Monooxygenase Activity (GO:0004511)

Cross-References

Database	Links
UNIPROT	O42091
Pfam	PF00351 PF12549
PROSITE	PS00367 PS51410

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