NucEnvDB

NucEnvDB

A database of Nuclear Envelope Proteins and their Interactions

CBP80/20-dependent translation initiation factor - Homo sapiens - NucEnvDB

CBP80/20-dependent translation initiation factor (Homo sapiens)

FASTA TEXT XML

Subcellular Location Biology & Function Interactions Cross-References

General Information

Protein Information
Protein Name	CBP80/20-dependent translation initiation factor
Accession Code	O43310
Gene	CTIF
Organism	Homo sapiens \| Human (Taxonomy: 9606)
Part of Reference Proteome?	Yes
Sequence (Length: 598)
MENSSAASASSEAGSSRSQEIEELERFIDSYVLEYQVQGLLADKTEGDGESERTQSHISQWTADCSEPLDSSCSFSRGRAPPQQNGSKDNSLDMLGTDIWAANTFDSFSGATWDLQPEKLDFTQFHRKVR HTPKQPLPHIDREGCGKGKLEDGDGINLNDIEKVLPAWQGYHPMPHEVEIAHTKKLFRRRRNDRRRQQRPPGGNKPQQHGDHQPGSAKHNRDHQKSYQGGSAPHPSGRPTHHGYSQNRRWHHGNMKHPPG DKGEAGAHRNAKETMTIENPKLEDTAGDTGHSSLEAPRSPDTLAPVASERLPPQQSGGPEVETKRKDSILPERIGERPKITLLQSSKDRLRRRLKEKDEVAVETTTPQQNKMDKLIEILNSMRNNSSDVD TKLTTFMEEAQNSTNSEEMLGEIVRTIYQKAVSDRSFAFTAAKLCDKMALFMVEGTKFRSLLLNMLQKDFTVREELQQQDVERWLGFITFLCEVFGTMRSSTGEPFRVLVCPIYTCLRELLQSQDVKEDA VLCCSMELQSTGRLLEEQLPEMMTELLASARDKMLCPSESMLTRSLLLEVIELHANSWNPLTPPITQYYNRTIQKLTA

Subcellular Location

Description
Cytoplasm, perinuclear region {Experimental EvidencePubMed:19648179}.
Position in the Nuclear Envelope
Location	Location ID	Description
Perinuclear Region	SL-0198	The perinuclear region is the cytoplasmic region just around the nucleus.
Membrane Topology
Topology	Source	Annotation Type
Unknown	UniProt	Sequence Analysis
Assigned Ontology terms

Cellular Component	Cytosol (GO:0005829) Perinuclear Region Of Cytoplasm (GO:0048471)

Biology & Function

Description
Specifically required for the pioneer round of mRNA translation mediated by the cap-binding complex (CBC), that takes place during or right after mRNA export via the nuclear pore complex (NPC). Acts via its interaction with the NCBP1/CBP80 component of the CBC complex and recruits the 40S small subunit of the ribosome via eIF3. In contrast, it is not involved in steady state translation, that takes place when the CBC complex is replaced by cytoplasmic cap-binding protein eIF4E. Also required for nonsense-mediated mRNA decay (NMD), the pioneer round of mRNA translation mediated by the cap-binding complex playing a central role in nonsense-mediated mRNA decay (NMD). {Experimental EvidencePubMed:19648179}.
Assigned Ontology terms

Biological Process	Nuclear-Transcribed MRNA Catabolic Process, Nonsense-Mediated Decay (GO:0000184) Regulation Of Translational Initiation (GO:0006446)
Molecular Function	RNA Binding (GO:0003723) Translation Activator Activity (GO:0008494)

Protein-Protein Interactions

Interactions with other proteins (9 interactors)

Partner (UniProt)		IntAct	Confidence score
A0A2U2H131	N-acetyltransferase domain-containing protein	EBI-2866199	0.00
Q86VS8	Protein Hook homolog 3 (h-hook3) (hHK3)	EBI-24326289	0.56
Q9NZD8	Maspardin (Acid cluster protein 33) (Spastic paraplegia 21 autosomal recessive Mast syndrome protein) (Spastic paraplegia 21 protein)	EBI-24333116	0.56
Q96MH2	Protein HEXIM2 (Hexamethylene bis-acetamide-inducible protein 2)	EBI-24352467	0.56
Q6P9E2	RECK protein	EBI-24373771	0.56
Q9NUU7	ATP-dependent RNA helicase DDX19A (EC 3.6.4.13) (DDX19-like protein) (DEAD box protein 19A)	EBI-24377593	0.67
A9UHW6	MIF4G domain-containing protein (SLBP-interacting protein 1) (hSLIP1)	EBI-24392534	0.56
Q8N5M1	ATP synthase mitochondrial F1 complex assembly factor 2 (ATP12 homolog)	EBI-24400192	0.56
Q9UMR2	ATP-dependent RNA helicase DDX19B (EC 3.6.4.13) (DEAD box RNA helicase DEAD5) (DEAD box protein 19B)	EBI-25260673	0.56

Cross-References

Database	Links
UNIPROT	O43310 B3KTR8 Q8IVD5
Pfam	PF02854
OMIM	613178
DisGeNET	9811

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