National and Kapodistrian University of Athens
Department of Biology
Biophysics & Bioinformatics Laboratory
Protein Information |
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|---|---|
| Protein Name | Protein pid-4 |
| Accession Code | O44749 |
| Gene | pid |
| Organism | Caenorhabditis elegans (Taxonomy: 6239) |
| Part of Reference Proteome? | Yes |
| Sequence (Length: 515) |
Description |
Position in the Nuclear Envelope |
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|---|---|---|
| Location | Location ID | Description |
| Perinuclear Region | SL-0198 | The perinuclear region is the cytoplasmic region just around the nucleus. | Membrane Topology |
| Topology | Source | Annotation Type |
| Unknown | UniProt | Sequence Analysis | Assigned Ontology terms |
Description |
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|---|---|
| Together with pid-5, it is involved in gene silencing mediated by a class of 21 nucleotide PIWI-interacting RNAs (piRNAs) that possess a uracil residue at the 5'-end (also called 21U-RNAs) and guide the Piwi protein prg-1 to its DNA targets for silencing (PubMed:33231880). Together with pid-5, it is required for the biogenesis of secondary and tertiary 22G-siRNAs (PubMed:33231880). Specifically, promotes the production of 22G-siRNAs from the 5' end of target mRNAs (PubMed:33231880). Together with pid-5, plays a role in small RNA-directed transgenerational epigenetic inheritance (also called RNAe) over several generations and germline immortality (PubMed:33231880). Together with pid-5, plays a role in the formation of liquid-like condensates in the cytoplasm called Z granules (PubMed:33231880). {Experimental EvidencePubMed:33231880}. | Assigned Ontology terms |
Interactions with other proteins (3 interactors) |
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National and Kapodistrian University of Athens
Department of Biology
Biophysics & Bioinformatics Laboratory