NucEnvDB

NucEnvDB

A database of Nuclear Envelope Proteins and their Interactions

Ubiquitin carboxyl-terminal hydrolase 2 - Gallus gallus - NucEnvDB

Ubiquitin carboxyl-terminal hydrolase 2 (Gallus gallus)

FASTA TEXT XML

Subcellular Location Biology & Function Cross-References

General Information

Protein Information
Protein Name	Ubiquitin carboxyl-terminal hydrolase 2
Accession Code	O57429
Gene	USP2
Organism	Gallus gallus \| Chicken (Taxonomy: 9031)
Part of Reference Proteome?	Yes
Sequence (Length: 357)
MAARMAPTPRSSKVVQGLTGLRNLGNTCFMNSILQCLSNTKELRDYCLQNQYLRDLNNNSRMRTALMSEFAKLIQLLWTSSPNDSVSPSEFKTQIQRYAPRFVGYNQQDAQEFLRFLLDGLHGEVNRVLV RPRANADTLDHLPDDEKSRQMWRRYQEREDSRVSDLFVGQLKSSLTCSECGYCSTAFDPFWDLSLPIPKKGYGEVTLMDCLRLFTKEDVLDGDEKPTCCRCKARTRCTKKFSIQKFPKILVLHLKRFSEA RIRASKLTTFVNFPLKDLDLREFASQSCNHAVYNLYAVSNHSGTTMGGHYTAYCKSPISSEWHSFNDSRVTPMSSSHVRSSDAYLLFYELASPSSRM

Subcellular Location

Description
Cytoplasm {By SimilarityUniProtKB:O88623}. Cytoplasm, perinuclear region {By SimilarityUniProtKB:O88623}.
Position in the Nuclear Envelope
Location	Location ID	Description
Perinuclear Region	SL-0198	The perinuclear region is the cytoplasmic region just around the nucleus.
Membrane Topology
Topology	Source	Annotation Type
Unknown	UniProt	Sequence Analysis
Assigned Ontology terms

Cellular Component	Cytoplasm (GO:0005737) Perinuclear Region Of Cytoplasm (GO:0048471)

Biology & Function

Description
Hydrolase that deubiquitinates polyubiquitinated target proteins such as MDM2, MDM4 and CCND1. Possesses both ubiquitin- specific peptidase and isopeptidase activities. May play a role in the regulation of the circadian clock. {By SimilarityUniProtKB:O75604, By SimilarityUniProtKB:O88623}.
Assigned Ontology terms

Biological Process	Protein Deubiquitination (GO:0016579) Rhythmic Process (GO:0048511) Ubiquitin-Dependent Protein Catabolic Process (GO:0006511)
Molecular Function	Cysteine-Type Deubiquitinase Activity (GO:0004843) Metal Ion Binding (GO:0046872)

Cross-References

Database	Links
UNIPROT	O57429
Pfam	PF00443
PROSITE	PS00972 PS00973 PS50235

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