C-Jun-amino-terminal kinase-interacting protein 4 - Homo sapiens

C-Jun-amino-terminal kinase-interacting protein 4 (Homo sapiens)

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Subcellular Location Biology & Function Interactions Cross-References

General Information

Protein Information
Protein Name	C-Jun-amino-terminal kinase-interacting protein 4
Accession Code	O60271
Gene	SPAG9
Organism	Homo sapiens \| Human (Taxonomy: 9606)
Part of Reference Proteome?	Yes
Sequence (Length: 1321)
MELEDGVVYQEEPGGSGAVMSERVSGLAGSIYREFERLIGRYDEEVVKELMPLVVAVLENLDSVFAQDQEHQVELELLRD DNEQLITQYEREKALRKHAEEKFIEFEDSQEQEKKDLQTRVESLESQTRQLELKAKNYADQISRLEEREAELKKEYNALH QRHTEMIHNYMEHLERTKLHQLSGSDQLESTAHSRIRKERPISLGIFPLPAGDGLLTPDAQKGGETPGSEQWKFQELSQP RSHTSLKVSNSPEPQKAVEQEDELSDVSQGGSKATTPASTANSDVATIPTDTPLKEENEGFVKVTDAPNKSEISKHIEVQ VAQETRNVSTGSAENEEKSEVQAIIESTPELDMDKDLSGYKGSSTPTKGIENKAFDRNTESLFEELSSAGSGLIGDVDEG ADLLGMGREVENLILENTQLLETKNALNIVKNDLIAKVDELTCEKDVLQGELEAVKQAKLKLEEKNRELEEELRKARAEA EDARQKAKDDDDSDIPTAQRKRFTRVEMARVLMERNQYKERLMELQEAVRWTEMIRASRENPAMQEKKRSSIWQFFSRLF SSSSNTTKKPEPPVNLKYNAPTSHVTPSVKKRSSTLSQLPGDKSKAFDFLSEETEASLASRREQKREQYRQVKAHVQKED GRVQAFGWSLPQKYKQVTNGQGENKMKNLPVPVYLRPLDEKDTSMKLWCAVGVNLSGGKTRDGGSVVGASVFYKDVAGLD TEGSKQRSASQSSLDKLDQELKEQQKELKNQEELSSLVWICTSTHSATKVLIIDAVQPGNILDSFTVCNSHVLCIASVPG ARETDYPAGEDLSESGQVDKASLCGSMTSNSSAETDSLLGGITVVGCSAEGVTGAATSPSTNGASPVMDKPPEMEAENSE VDENVPTAEEATEATEGNAGSAEDTVDISQTGVYTEHVFTDPLGVQIPEDLSPVYQSSNDSDAYKDQISVLPNEQDLVRE EAQKMSSLLPTMWLGAQNGCLYVHSSVAQWRKCLHSIKLKDSILSIVHVKGIVLVALADGTLAIFHRGVDGQWDLSNYHL LDLGRPHHSIRCMTVVHDKVWCGYRNKIYVVQPKAMKIEKSFDAHPRKESQVRQLAWVGDGVWVSIRLDSTLRLYHAHTY QHLQDVDIEPYVSKMLGTGKLGFSFVRITALMVSCNRLWVGTGNGVIISIPLTETNKTSGVPGNRPGSVIRVYGDENSDK VTPGTFIPYCSMAHAQLCFHGHRDAVKFFVAVPGQVISPQSSSSGTDLTGDKAGPSAQEPGSQTPLKSMLVISGGEGYID FRMGDEGGESELLGEDLPLEPSVTKAERSHLIVWQVMYGNE

Structure Viewer (PDB: 2W83)

Subcellular Location

Description
Cytoplasm {By SimilarityUniProtKB:Q58A65}. Cytoplasm, perinuclear region {By SimilarityUniProtKB:Q58A65}. Lysosome membrane {Experimental EvidencePubMed:29146937}. Note=Perinuclear distribution in response to stress signals such as UV radiation. {By SimilarityUniProtKB:Q58A65}. [Isoform 5]: Cytoplasmic vesicle, secretory vesicle, acrosome {ECO:0000269\|PubMed:15693750}. Note=Associated with the plasma membrane of the acrosomal compartment and also localizes in the acrosome matrix. {ECO:0000269\|PubMed:15693750}.
Position in the Nuclear Envelope
Location	Location ID	Description
Perinuclear Region	SL-0198	The perinuclear region is the cytoplasmic region just around the nucleus.
Membrane Topology
Topology	Source	Annotation Type
Unknown	UniProt	Sequence Analysis
Assigned Ontology terms

Cellular Component	Acrosomal Vesicle (GO:0001669) Centriolar Satellite (GO:0034451) Cytoplasm (GO:0005737) Cytosol (GO:0005829) Extracellular Exosome (GO:0070062) Lysosomal Membrane (GO:0005765) Perinuclear Region Of Cytoplasm (GO:0048471)

Biology & Function

Description
The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module (PubMed:14743216). Regulates lysosomal positioning by acting as an adapter protein which links PIP4P1-positive lysosomes to the dynein- dynactin complex (PubMed:29146937). Assists PIKFYVE selective functionality in microtubule-based endosome-to-TGN trafficking (By similarity). {By SimilarityUniProtKB:Q58A65, Experimental EvidencePubMed:14743216, Experimental EvidencePubMed:29146937}.
Assigned Ontology terms

Biological Process	Lysosome Localization (GO:0032418) Negative Regulation Of Dendrite Extension (GO:1903860) Negative Regulation Of Neuron Differentiation (GO:0045665) Negative Regulation Of Protein Phosphorylation (GO:0001933) Positive Regulation Of Cell Migration (GO:0030335) Positive Regulation Of Neuron Differentiation (GO:0045666) Retrograde Transport, Endosome To Golgi (GO:0042147) Striated Muscle Cell Differentiation (GO:0051146) Vesicle-Mediated Transport (GO:0016192)
Molecular Function	Identical Protein Binding (GO:0042802) JUN Kinase Binding (GO:0008432) Kinesin Binding (GO:0019894) MAP-Kinase Scaffold Activity (GO:0005078) Signaling Receptor Complex Adaptor Activity (GO:0030159)

Protein-Protein Interactions

Interactions with Nuclear Envelope proteins (4 interactors)

Partner (NucEnvDB)		IntAct	Confidence score
O60271	Self	EBI-7141074	0.44
P61026	Ras-related protein Rab-10	EBI-25436875	0.40
Q00613	Heat shock factor protein 1	EBI-11911387	0.00
Q9UPT6	C-Jun-amino-terminal kinase-interacting protein 3	EBI-21663692	0.35
Interactions with other proteins (82 interactors)

Partner (UniProt)		IntAct	Confidence score
P19838	Nuclear factor NF-kappa-B p105 subunit (DNA-binding factor KBF1) (EBP-1) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1) [Cleaved into: Nuclear factor NF-kappa-B p50 subunit]	EBI-353534	0.69
O88447	Kinesin light chain 1 (KLC 1)	EBI-7681059	0.27
Q14240	Eukaryotic initiation factor 4A-II (eIF-4A-II) (eIF4A-II) (EC 3.6.4.13) (ATP-dependent RNA helicase eIF4A-2)	EBI-1068469	0.00
P53350	Serine/threonine-protein kinase PLK1 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-1) (Serine/threonine-protein kinase 13) (STPK13)	EBI-2372594	0.73
Q07832	Serine/threonine-protein kinase PLK1 (EC 2.7.11.21) (Polo-like kinase 1) (PLK-1) (Serine/threonine-protein kinase 13) (STPK13)	EBI-2560950	0.40
Q8ZED8	Exoribonuclease 2 (EC 3.1.13.1) (Exoribonuclease II) (RNase II) (Ribonuclease II)	EBI-2866304	0.00
P62330	ADP-ribosylation factor 6 (EC 3.6.5.2)	EBI-7140974	0.62
P84077	ADP-ribosylation factor 1 (EC 3.6.5.2)	EBI-7141242	0.44
Q9HC52	Chromobox protein homolog 8 (Polycomb 3 homolog) (Pc3) (hPc3) (Rectachrome 1)	EBI-3951861	0.35
Q9GZQ8	Microtubule-associated proteins 1A/1B light chain 3B (Autophagy-related protein LC3 B) (Autophagy-related ubiquitin-like modifier LC3 B) (MAP1 light chain 3-like protein 2) (MAP1A/MAP1B light chain 3 B) (MAP1A/MAP1B LC3 B) (Microtubule-associated protein 1 light chain 3 beta)	EBI-7190550	0.37
Q9NPJ4	Proline-rich nuclear receptor coactivator 2	EBI-7316035	0.37
P62331	ADP-ribosylation factor 6 (EC 3.6.5.2)	EBI-7832567	0.40
Q96A65	Exocyst complex component 4 (Exocyst complex component Sec8)	EBI-9817790	0.56
P23771	Trans-acting T-cell-specific transcription factor GATA-3 (GATA-binding factor 3)	EBI-10891010	0.35
A3KN83	Protein strawberry notch homolog 1 (Monocyte protein 3) (MOP-3)	EBI-11898766	0.00
Q9UQ88	Cyclin-dependent kinase 11A (EC 2.7.11.22) (Cell division cycle 2-like protein kinase 2) (Cell division protein kinase 11A) (Galactosyltransferase-associated protein kinase p58/GTA) (PITSLRE serine/threonine-protein kinase CDC2L2)	EBI-11901851	0.00
Q9UKN8	General transcription factor 3C polypeptide 4 (EC 2.3.1.48) (TF3C-delta) (Transcription factor IIIC 90 kDa subunit) (TFIIIC 90 kDa subunit) (TFIIIC90) (Transcription factor IIIC subunit delta)	EBI-11901842	0.00
Q9UBC2	Epidermal growth factor receptor substrate 15-like 1 (Eps15-related protein) (Eps15R)	EBI-11901833	0.00
Q8WUA4	General transcription factor 3C polypeptide 2 (TF3C-beta) (Transcription factor IIIC 110 kDa subunit) (TFIIIC 110 kDa subunit) (TFIIIC110) (Transcription factor IIIC subunit beta)	EBI-11901824	0.00
P11274	Breakpoint cluster region protein (EC 2.7.11.1) (Renal carcinoma antigen NY-REN-26)	EBI-11901815	0.00
P30291	Wee1-like protein kinase (WEE1hu) (EC 2.7.10.2) (Wee1A kinase)	EBI-11907279	0.00
P33991	DNA replication licensing factor MCM4 (EC 3.6.4.12) (CDC21 homolog) (P1-CDC21)	EBI-11907576	0.00
P33993	DNA replication licensing factor MCM7 (EC 3.6.4.12) (CDC47 homolog) (P1.1-MCM3)	EBI-11907675	0.00
P49736	DNA replication licensing factor MCM2 (EC 3.6.4.12) (Minichromosome maintenance protein 2 homolog) (Nuclear protein BM28)	EBI-11908484	0.00
Q06945	Transcription factor SOX-4	EBI-11911777	0.00
Q12955	Ankyrin-3 (ANK-3) (Ankyrin-G)	EBI-11912325	0.00
Q14566	DNA replication licensing factor MCM6 (EC 3.6.4.12) (p105MCM)	EBI-11913337	0.00
Q14C86	GTPase-activating protein and VPS9 domain-containing protein 1 (GAPex-5) (Rab5-activating protein 6)	EBI-11913870	0.00
Q14683	Structural maintenance of chromosomes protein 1A (SMC protein 1A) (SMC-1-alpha) (SMC-1A) (Sb1.8)	EBI-11913616	0.00
Q6IN85	Serine/threonine-protein phosphatase 4 regulatory subunit 3A (SMEK homolog 1)	EBI-11917442	0.00
Q96BY7	Autophagy-related protein 2 homolog B	EBI-11926258	0.00
Q9NY27	Serine/threonine-protein phosphatase 4 regulatory subunit 2	EBI-11934518	0.00
Q9P260	RAB11-binding protein RELCH (LisH domain and HEAT repeat-containing protein KIAA1468) (RAB11 binding and LisH domain, coiled-coil and HEAT repeat-containing) (RAB11-binding protein containing LisH, coiled-coil, and HEAT repeats)	EBI-11935551	0.00
Q9UQE7	Structural maintenance of chromosomes protein 3 (SMC protein 3) (SMC-3) (Basement membrane-associated chondroitin proteoglycan) (Bamacan) (Chondroitin sulfate proteoglycan 6) (Chromosome-associated polypeptide) (hCAP)	EBI-11939891	0.00
Q9Y4E8	Ubiquitin carboxyl-terminal hydrolase 15 (EC 3.4.19.12) (Deubiquitinating enzyme 15) (Ubiquitin thioesterase 15) (Ubiquitin-specific-processing protease 15) (Unph-2) (Unph4)	EBI-11941617	0.00
Q9Y6Y0	Influenza virus NS1A-binding protein (NS1-BP) (NS1-binding protein) (Aryl hydrocarbon receptor-associated protein 3) (Kelch-like protein 39)	EBI-11942633	0.00
Q8TBP5	Membrane protein FAM174A (Hepatitis C virus NS5A-transactivated protein 6) (HCV NS5A-transactivated protein 6) (Transmembrane protein 157)	EBI-21502646	0.35
Q8N6T3	ADP-ribosylation factor GTPase-activating protein 1 (ARF GAP 1) (ADP-ribosylation factor 1 GTPase-activating protein) (ARF1 GAP) (ARF1-directed GTPase-activating protein)	EBI-21541414	0.35
Q9UF02	Voltage-dependent calcium channel gamma-5 subunit (Neuronal voltage-gated calcium channel gamma-5 subunit) (Transmembrane AMPAR regulatory protein gamma-5) (TARP gamma-5)	EBI-21554221	0.35
Q86VU5	Catechol O-methyltransferase domain-containing protein 1 (EC 2.1.1.-)	EBI-21596714	0.35
Q6EMK4	Vasorin (Protein slit-like 2)	EBI-21651359	0.35
P08247	Synaptophysin (Major synaptic vesicle protein p38)	EBI-21652717	0.35
Q2TBA0	Kelch-like protein 40 (Kelch repeat and BTB domain-containing protein 5) (Sarcosynapsin)	EBI-21658220	0.35
Q96MC5	bMERB domain-containing protein 1	EBI-21663233	0.35
O96006	E3 SUMO-protein ligase ZBED1 (EC 2.3.2.-) (DNA replication-related element-binding factor) (Putative Ac-like transposable element) (Zinc finger BED domain-containing protein 1) (dREF homolog)	EBI-21692488	0.35
A6NED2	RCC1 domain-containing protein 1	EBI-21716445	0.35
P31350	Ribonucleoside-diphosphate reductase subunit M2 (EC 1.17.4.1) (Ribonucleotide reductase small chain) (Ribonucleotide reductase small subunit)	EBI-21732275	0.35
Q7LG56	Ribonucleoside-diphosphate reductase subunit M2 B (EC 1.17.4.1) (TP53-inducible ribonucleotide reductase M2 B) (p53-inducible ribonucleotide reductase small subunit 2-like protein) (p53R2)	EBI-21732528	0.35
Q8WYK0	Acetyl-coenzyme A thioesterase (EC 3.1.2.1) (Acyl-CoA thioester hydrolase 12) (Acyl-coenzyme A thioesterase 12) (Acyl-CoA thioesterase 12) (Cytoplasmic acetyl-CoA hydrolase 1) (CACH-1) (hCACH-1) (START domain-containing protein 15) (StARD15)	EBI-21732608	0.35
O00592	Podocalyxin (GCTM-2 antigen) (Gp200) (Podocalyxin-like protein 1) (PC) (PCLP-1)	EBI-21750748	0.35
Q96CA5	Baculoviral IAP repeat-containing protein 7 (EC 2.3.2.27) (Kidney inhibitor of apoptosis protein) (KIAP) (Livin) (Melanoma inhibitor of apoptosis protein) (ML-IAP) (RING finger protein 50) (RING-type E3 ubiquitin transferase BIRC7) [Cleaved into: Baculoviral IAP repeat-containing protein 7 30kDa subunit (Truncated livin) (p30-Livin) (tLivin)]	EBI-21754959	0.35
O14863	Zinc transporter 4 (ZnT-4) (Solute carrier family 30 member 4)	EBI-21768088	0.35
O95159	Zinc finger protein-like 1 (Zinc finger protein MCG4)	EBI-21768155	0.35
P06753	Tropomyosin alpha-3 chain (Gamma-tropomyosin) (Tropomyosin-3) (Tropomyosin-5) (hTM5)	EBI-21768209	0.35
P09493	Tropomyosin alpha-1 chain (Alpha-tropomyosin) (Tropomyosin-1)	EBI-21768262	0.35
P16150	Leukosialin (GPL115) (Galactoglycoprotein) (GALGP) (Leukocyte sialoglycoprotein) (Sialophorin) (CD antigen CD43) [Cleaved into: CD43 cytoplasmic tail (CD43-ct) (CD43ct)]	EBI-21768371	0.35
Q14108	Lysosome membrane protein 2 (85 kDa lysosomal membrane sialoglycoprotein) (LGP85) (CD36 antigen-like 2) (Lysosome membrane protein II) (LIMP II) (Scavenger receptor class B member 2) (CD antigen CD36)	EBI-21768396	0.35
Q147U7	Single-pass membrane and coiled-coil domain-containing protein 1 (Single-pass membrane protein with coiled-coil domains 1)	EBI-21768421	0.35
Q2T9K0	Transmembrane protein 44	EBI-21768445	0.35
Q5XKK7	Protein FAM219B	EBI-21768464	0.35
Q8N565	Melanoregulin (Dilute suppressor protein homolog)	EBI-21768514	0.35
Q96L93	Kinesin-like protein KIF16B (Sorting nexin-23)	EBI-21768545	0.35
Q9BWT6	Meiotic nuclear division protein 1 homolog	EBI-21768576	0.35
Q9NWA0	Mediator of RNA polymerase II transcription subunit 9 (Mediator complex subunit 9)	EBI-21768607	0.35
Q9NPJ6	Mediator of RNA polymerase II transcription subunit 4 (Activator-recruited cofactor 36 kDa component) (ARC36) (Mediator complex subunit 4) (TRAP/SMCC/PC2 subunit p36 subunit) (Vitamin D3 receptor-interacting protein complex 36 kDa component) (DRIP36)	EBI-25472202	0.27
P61006	Ras-related protein Rab-8A (EC 3.6.5.2) (Oncogene c-mel)	EBI-21006330	0.62
Q5NFC5	Type II secretion system protein H (General secretion pathway protein H)	EBI-22299450	0.37
Q5NES6	Curli production assembly/transport component CsgG	EBI-22299440	0.37
H9EJ66	Non-structural protein 3	EBI-25685143	0.35
P0DTC3	ORF3a protein (ORF3a) (Accessory protein 3a) (Protein 3a) (Protein U274) (Protein X1)	EBI-25686340	0.35
Q2TAZ0	Autophagy-related protein 2 homolog A	EBI-26443127	0.35
P22612	cAMP-dependent protein kinase catalytic subunit gamma (PKA C-gamma) (EC 2.7.11.11)	EBI-28934688	0.35
P36507	Dual specificity mitogen-activated protein kinase kinase 2 (MAP kinase kinase 2) (MAPKK 2) (EC 2.7.12.2) (ERK activator kinase 2) (MAPK/ERK kinase 2) (MEK 2)	EBI-28935019	0.35
P51617	Interleukin-1 receptor-associated kinase 1 (IRAK-1) (EC 2.7.11.1)	EBI-28935882	0.35
Q8TDX7	Serine/threonine-protein kinase Nek7 (EC 2.7.11.1) (Never in mitosis A-related kinase 7) (NimA-related protein kinase 7)	EBI-28943744	0.35
Q92918	Mitogen-activated protein kinase kinase kinase kinase 1 (EC 2.7.11.1) (Hematopoietic progenitor kinase) (MAPK/ERK kinase kinase kinase 1) (MEK kinase kinase 1) (MEKKK 1)	EBI-28944233	0.35
Q96QS6	Serine/threonine-protein kinase H2 (EC 2.7.11.1) (Protein serine kinase H2) (PSK-H2)	EBI-28944559	0.35
Q99502	Eyes absent homolog 1 (EC 3.1.3.16) (EC 3.1.3.48)	EBI-27113432	0.35
O15297	Protein phosphatase 1D (EC 3.1.3.16) (Protein phosphatase 2C isoform delta) (PP2C-delta) (Protein phosphatase magnesium-dependent 1 delta) (p53-induced protein phosphatase 1)	EBI-27113880	0.35
O14830	Serine/threonine-protein phosphatase with EF-hands 2 (PPEF-2) (EC 3.1.3.16)	EBI-27113806	0.35
Q8N3J5	Protein phosphatase 1K, mitochondrial (EC 3.1.3.16) (PP2C domain-containing protein phosphatase 1K) (PP2C-like mitochondrial protein) (PP2C-type mitochondrial phosphoprotein phosphatase) (PTMP) (Protein phosphatase 2C isoform kappa) (PP2C-kappa)	EBI-27114011	0.35
P56180	Putative tyrosine-protein phosphatase TPTE (EC 3.1.3.48) (Cancer/testis antigen 44) (CT44) (Transmembrane phosphatase with tensin homology) (Tumor antigen BJ-HCC-5)	EBI-27115406	0.35

Cross-References

Database	Links
UNIPROT	O60271 A6H8U5 A8MSX0 B4DHH2 O60905 Q3KQU8 Q3MKM7 Q86WC7 Q86WC8 Q8IZX7 Q96II0 Q9H811
PDB	2W83
Pfam	PF16471 PF09744
PROSITE	PS51776 PS51777
OMIM	605430
DisGeNET	9043

C-Jun-amino-terminal kinase-interacting protein 4 (Homo sapiens)

General Information

Protein Information

Structure Viewer (PDB: 2W83)

Subcellular Location

Description Show

Position in the Nuclear Envelope

Membrane Topology

Assigned Ontology terms

Biology & Function

Description Hide

Assigned Ontology terms

Protein-Protein Interactions

Interactions with Nuclear Envelope proteins (4 interactors)

Interactions with other proteins (82 interactors)

Cross-References

Database

Links

Description

Description