The host nuclear envelope is a membrane system which surrounds the host nucleoplasm of eukaryotic cells. It is composed of the nuclear lamina, nuclear pore complexes and two nuclear membranes. The space between the two membranes is called the host nuclear intermembrane space. Note: This location is defined for viral proteins that appear in the Nuclear Envelope of infected host cells
The membrane surrounding the host nucleus. This term is used when it is not known if the protein is found in or associated with the inner or outer host nuclear membrane. Note: This location is defined for viral proteins that appear in the Nuclear Membrane of infected host cells
Plays a major role in assembly and budding of virion. Condensates the ribonucleocapsid core during virus assembly. Shut off cellular transcription by inhibiting mRNA nuclear export through direct interaction with host RAE1-NUP98 complex. This shutoff presumably inhibits interferon signaling and thus establishment of antiviral state in virus infected cells. Induces cell-rounding, cytoskeleton disorganization and apoptosis in infected cell (By similarity). {By
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National and Kapodistrian University of Athens
Department of Biology
Biophysics & Bioinformatics Laboratory