NucEnvDB

NucEnvDB

A database of Nuclear Envelope Proteins and their Interactions

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 - Bos taurus - NucEnvDB

Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 (Bos taurus)

FASTA TEXT XML

Subcellular Location Biology & Function Cross-References

General Information

Protein Information
Protein Name	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2
Accession Code	P11017
Gene	GNB2
Organism	Bos taurus \| Cattle (Taxonomy: 9913)
Part of Reference Proteome?	Yes
Sequence (Length: 340)
MSELEQLRQEAEQLRNQIRDARKACGDSTLTQITAGLDPVGRIQMRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCAYAPSGNFVACGGLDNICSIYSLKTRE GNVRVSRELPGHTGYLSCCRFLDDNQIITSSGDTTCALWDIETGQQTVGFAGHSGDVMSLSLAPDGRTFVSGACDASIKLWDVRDSMCRQTFIGHESDINAVAFFPNGYAFTTGSDDATCRLFDLRADQE LLMYSHDNIICGITSVAFSRSGRLLLAGYDDFNCNIWDAMKGDRAGVLAGHDNRVSCLGVTDDGMAVATGSWDSFLKIWN

Subcellular Location

Description
Cytoplasm, perinuclear region {By SimilarityUniProtKB:P62879}. Cell membrane {By SimilarityUniProtKB:P62879}.
Position in the Nuclear Envelope
Location	Location ID	Description
Perinuclear Region	SL-0198	The perinuclear region is the cytoplasmic region just around the nucleus.
Membrane Topology
Topology	Source	Annotation Type
Unknown	UniProt	Sequence Analysis
Assigned Ontology terms

Cellular Component	Cytoplasm (GO:0005737) Heterotrimeric G-Protein Complex (GO:0005834) Perinuclear Region Of Cytoplasm (GO:0048471)

Biology & Function

Description
Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
Assigned Ontology terms

Biological Process	G Protein-Coupled Receptor Signaling Pathway (GO:0007186) Regulation Of Potassium Ion Transmembrane Transport (GO:1901379)
Molecular Function	GTPase Activity (GO:0003924) GTPase Binding (GO:0051020) Protein-Containing Complex Binding (GO:0044877) Signaling Receptor Complex Adaptor Activity (GO:0030159)

Cross-References

Database	Links
UNIPROT	P11017 A5D7A9
Pfam	PF00400
PROSITE	PS00678 PS50082 PS50294

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