NucEnvDB

NucEnvDB

A database of Nuclear Envelope Proteins and their Interactions

Sodium channel protein type 5 subunit alpha - Rattus norvegicus - NucEnvDB

Sodium channel protein type 5 subunit alpha (Rattus norvegicus)

FASTA TEXT XML

Subcellular Location Biology & Function Interactions Cross-References

General Information

Protein Information
Protein Name	Sodium channel protein type 5 subunit alpha
Accession Code	P15389
Gene	Scn5a
Organism	Rattus norvegicus \| Norway rat (Taxonomy: 10116)
Part of Reference Proteome?	Yes
Sequence (Length: 2019)
MANLLLPRGTSSFRRFTRESLAAIEKRMAEKQARGGSATSQESREGLQEEEAPRPQLDLQASKKLPDLYGNPPRELIGEP LEDLDPFYSTQKTFIVLNKGKTIFRFSATNALYVLSPFHPVRRAAVKILVHSLFSMLIMCTILTNCVFMAQHDPPPWTKY VEYTFTAIYTFESLVKILARGFCLHAFTFLRDPWNWLDFSVIVMAYTTEFVDLGNVSALRTFRVLRALKTISVISGLKTI VGALIQSVKKLADVMVLTVFCLSVFALIGLQLFMGNLRHKCVRNFTELNGTNGSVEADGLVWNSLDVYLNDPANYLLKNG TTDVLLCGNSSDAGTCPEGYRCLKAGENPDHGYTSFDSFAWAFLALFRLMTQDCWERLYQQTLRSAGKIYMIFFMLVIFL GSFYLVNLILAVVAMAYEEQNQATIAETEEKEKRFQEAMEMLKKEHEALTIRGVDTVSRSSLEMSPLAPVTNHERKSKRR KRLSSGTEDGGDDRLPKSDSEDGPRALNQLSLTHGLSRTSMRPRSSRGSIFTFRRRDQGSEADFADDENSTAGESESHRT SLLVPWPLRHPSAQGQPGPGASAPGYVLNGKRNSTVDCNGVVSLLGAGDAEATSPGSYLLRPMVLDRPPDTTTPSEEPGG PQMLTPQAPCADGFEEPGARQRALSAVSVLTSALEELEESHRKCPPCWNRFAQHYLIWECCPLWMSIKQKVKFVVMDPFA DLTITMCIVLNTLFMALEHYNMTAEFEEMLQVGNLVFTGIFTAEMTFKIIALDPYYYFQQGWNIFDSIIVILSLMELGLS RMGNLSVLRSFRLLRVFKLAKSWPTLNTLIKIIGNSVGALGNLTLVLAIIVFIFAVVGMQLFGKNYSELRHRISDSGLLP RWHMMDFFHAFLIIFRILCGEWIETMWDCMEVSGQSLCLLVFLLVMVIGNLVVLNLFLALLLSSFSADNLTAPDEDGEMN NLQLALARIQRGLRFVKRTTWDFCCGILRRRPKKPAALATHSQLPSCITAPRSPPPPEVEKVPPARKETRFEEDKRPGQG TPGDSEPVCVPIAVAESDTEDQEEDEENSLGTEEESSKQESQVVSGGHEPYQEPRAWSQVSETTSSEAGASTSQADWQQE QKTEPQAPGCGETPEDSYSEGSTADMTNTADLLEQIPDLGEDVKDPEDCFTEGCVRRCPCCMVDTTQSPGKVWWRLRKTC YRIVEHSWFETFIIFMILLSSGALAFEDIYLEERKTIKVLLEYADKMFTYVFVLEMLLKWVAYGFKKYFTNAWCWLDFLI VDVSLVSLVANTLGFAEMGPIKSLRTLRALRPLRALSRFEGMRVVVNALVGAIPSIMNVLLVCLIFWLIFSIMGVNLFAG KFGRCINQTEGDLPLNYTIVNNKSECESFNVTGELYWTKVKVNFDNVGAGYLALLQVATFKGWMDIMYAAVDSRGYEEQP QWEDNLYMYIYFVVFIIFGSFFTLNLFIGVIIDNFNQQKKKLGGQDIFMTEEQKKYYNAMKKLGSKKPQKPIPRPLNKYQ GFIFDIVTKQAFDVTIMFLICLNMVTMMVETDDQSPEKVNILAKINLLFVAIFTGECIVKMAALRHYYFTNSWNIFDFVV VILSIVGTVLSDIIQKYFFSPTLFRVIRLARIGRILRLIRGAKGIRTLLFALMMSLPALFNIGLLLFLVMFIYSIFGMAN FAYVKWEAGIDDMFNFQTFANSMLCLFQITTSAGWDGLLSPILNTGPPYCDPNLPNSNGSRGNCGSPAVGILFFTTYIII SFLIVVNMYIAIILENFSVATEESTEPLSEDDFDMFYEIWEKFDPEATQFIEYLALSDFADALSEPLRIAKPNQISLINM DLPMVSGDRIHCMDILFAFTKRVLGESGEMDALKIQMEEKFMAANPSKISYEPITTTLRRKHEEVSATVIQRAFRRHLLQ RSVKHASFLFRQQAGGSGLSDEDAPEREGLIAYMMNGNFSRRSAPLSSSSISSTSFPPSYDSVTRATSDNLPVRASDYSR SEDLADFPPSPDRDRESIV

Structure Viewer (PDB: 7K18)

Subcellular Location

Description
Cell membrane {By SimilarityUniProtKB:Q14524}; Multi-pass membrane protein {By SimilarityUniProtKB:D0E0C2}. Cytoplasm, perinuclear region {By SimilarityUniProtKB:Q14524}. Cell membrane, sarcolemma, T-tubule {ECO:0000269\|PubMed:15579534}. Note=RANGRF promotes trafficking to the cell membrane. {By SimilarityUniProtKB:Q14524}.
Position in the Nuclear Envelope
Location	Location ID	Description
Perinuclear Region	SL-0198	The perinuclear region is the cytoplasmic region just around the nucleus.
Membrane Topology
Topology	Source	Annotation Type
Transmembrane	UniProt	By Similarity {ECO:0000250\|UniProtKB:D0E0C2}
Assigned Ontology terms

Cellular Component	Caveola (GO:0005901) Cell Surface (GO:0009986) Endoplasmic Reticulum (GO:0005783) Intercalated Disc (GO:0014704) Lateral Plasma Membrane (GO:0016328) Perinuclear Region Of Cytoplasm (GO:0048471) Plasma Membrane (GO:0005886) Sarcolemma (GO:0042383) Sodium Channel Complex (GO:0034706) T-Tubule (GO:0030315) Voltage-Gated Sodium Channel Complex (GO:0001518) Z Disc (GO:0030018)

Biology & Function

Description
This protein mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. It is a tetrodotoxin-resistant Na(+) channel isoform. This channel is responsible for the initial upstroke of the action potential. Channel inactivation is regulated by intracellular calcium levels. {By SimilarityUniProtKB:Q14524, By SimilarityUniProtKB:Q9JJV9}.
Assigned Ontology terms

Biological Process	Atrial Cardiac Muscle Cell Action Potential (GO:0086014) AV Node Cell Action Potential (GO:0086016) AV Node Cell To Bundle Of His Cell Communication (GO:0086067) Brainstem Development (GO:0003360) Bundle Of His Cell Action Potential (GO:0086043) Cardiac Muscle Cell Action Potential Involved In Contraction (GO:0086002) Cardiac Muscle Contraction (GO:0060048) Cardiac Ventricle Development (GO:0003231) Cellular Response To Calcium Ion (GO:0071277) Cerebellum Development (GO:0021549) Membrane Depolarization (GO:0051899) Membrane Depolarization During Action Potential (GO:0086010) Membrane Depolarization During Atrial Cardiac Muscle Cell Action Potential (GO:0098912) Membrane Depolarization During AV Node Cell Action Potential (GO:0086045) Membrane Depolarization During Bundle Of His Cell Action Potential (GO:0086048) Membrane Depolarization During Cardiac Muscle Cell Action Potential (GO:0086012) Membrane Depolarization During Purkinje Myocyte Cell Action Potential (GO:0086047) Membrane Depolarization During SA Node Cell Action Potential (GO:0086046) Neuronal Action Potential (GO:0019228) Odontogenesis Of Dentin-Containing Tooth (GO:0042475) Positive Regulation Of Action Potential (GO:0045760) Positive Regulation Of Epithelial Cell Proliferation (GO:0050679) Positive Regulation Of Heart Rate (GO:0010460) Positive Regulation Of Sodium Ion Transport (GO:0010765) Regulation Of Atrial Cardiac Muscle Cell Membrane Depolarization (GO:0060371) Regulation Of Atrial Cardiac Muscle Cell Membrane Repolarization (GO:0060372) Regulation Of Cardiac Muscle Cell Contraction (GO:0086004) Regulation Of Heart Rate (GO:0002027) Regulation Of Heart Rate By Cardiac Conduction (GO:0086091) Regulation Of Sodium Ion Transmembrane Transport (GO:1902305) Regulation Of Ventricular Cardiac Muscle Cell Membrane Depolarization (GO:0060373) Regulation Of Ventricular Cardiac Muscle Cell Membrane Repolarization (GO:0060307) Response To Denervation Involved In Regulation Of Muscle Adaptation (GO:0014894) Response To Organic Cyclic Compound (GO:0014070) SA Node Cell Action Potential (GO:0086015) Sodium Ion Import Across Plasma Membrane (GO:0098719) Sodium Ion Transmembrane Transport (GO:0035725) Sodium Ion Transport (GO:0006814) Telencephalon Development (GO:0021537) Ventricular Cardiac Muscle Cell Action Potential (GO:0086005)
Molecular Function	Ankyrin Binding (GO:0030506) Calmodulin Binding (GO:0005516) Enzyme Binding (GO:0019899) Fibroblast Growth Factor Binding (GO:0017134) Nitric-Oxide Synthase Binding (GO:0050998) Protein Domain Specific Binding (GO:0019904) Protein Kinase Binding (GO:0019901) Scaffold Protein Binding (GO:0097110) Transmembrane Transporter Binding (GO:0044325) Ubiquitin Protein Ligase Binding (GO:0031625) Voltage-Gated Ion Channel Activity (GO:0005244) Voltage-Gated Sodium Channel Activity (GO:0005248) Voltage-Gated Sodium Channel Activity Involved In AV Node Cell Action Potential (GO:0086060) Voltage-Gated Sodium Channel Activity Involved In Bundle Of His Cell Action Potential (GO:0086061) Voltage-Gated Sodium Channel Activity Involved In Cardiac Muscle Cell Action Potential (GO:0086006) Voltage-Gated Sodium Channel Activity Involved In Purkinje Myocyte Action Potential (GO:0086062) Voltage-Gated Sodium Channel Activity Involved In SA Node Cell Action Potential (GO:0086063)

Protein-Protein Interactions

Interactions with other proteins (2 interactors)

Partner (UniProt)		IntAct	Confidence score
Q64273	Inward rectifier potassium channel 2 (Inward rectifier K(+) channel Kir2.1) (IRK-1) (RBL-IRK1) (Potassium channel, inwardly rectifying subfamily J member 2)	EBI-15981683	0.35
Q62696	Disks large homolog 1 (Synapse-associated protein 97) (SAP-97) (SAP97)	EBI-15981701	0.35

Cross-References

Database	Links
UNIPROT	P15389 Q925G6
PDB	6UZ0 6UZ3 7FBS 7K18
Pfam	PF00520 PF06512 PF11933

Powered by W3.css | Privacy Notice

x

This website uses cookies to improve user experience. By using NucEnvDB you consent to all cookies in accordance with our privacy policy. OK