National and Kapodistrian University of Athens
Department of Biology
Biophysics & Bioinformatics Laboratory
Protein Information |
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|---|---|
| Protein Name | Interferon-induced GTP-binding protein Mx2 |
| Accession Code | P20592 |
| Gene | MX2 |
| Organism | Homo sapiens | Human (Taxonomy: 9606) |
| Part of Reference Proteome? | Yes |
| Sequence (Length: 715) |
Structure Viewer (PDB: 4WHJ) |
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Description |
Position in the Nuclear Envelope |
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|---|---|---|
| Location | Location ID | Description |
| Nuclear Envelope | SL-0178 | The nuclear envelope is a membrane system which surrounds the nucleoplasm of eukaryotic cells. It is composed of the nuclear lamina, nuclear pore complexes and two nuclear membranes. The space between the two membranes is called the nuclear intermembrane space. |
| Nuclear Pore Complex | SL-0185 | The nuclear pore complex (NPC) constitutes the exclusive means of nucleocytoplasmic transport. NPCs allow the passive diffusion of ions and small molecules and the active bidirectional transport of macromolecules such as proteins, RNAs etc across the double-membrane nuclear envelope.The NPC is composed of at least 30 distinct subunits known as Nucleoporins (NUPs). | Membrane Topology |
| Topology | Source | Annotation Type |
| Unknown | UniProt | Sequence Analysis | Assigned Ontology terms |
Description |
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|---|---|
| Interferon-induced dynamin-like GTPase with potent antiviral activity against human immunodeficiency virus type 1 (HIV-1). Acts by targeting the viral capsid and affects the nuclear uptake and/or stability of the HIV-1 replication complex and the subsequent chromosomal integration of the proviral DNA. Exhibits antiviral activity also against simian immunodeficiency virus (SIV-mnd). May play a role in regulating nucleocytoplasmic transport and cell-cycle progression. {Experimental EvidencePubMed:15184662, Experimental EvidencePubMed:24048477, Experimental EvidencePubMed:24055605, Experimental EvidencePubMed:24121441}. | Assigned Ontology terms |
Interactions with other proteins (6 interactors) |
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Database | Links |
| UNIPROT | P20592 B7Z5D3 D3DSI7 |
| PDB | 4WHJ 4X0R 5UOT |
| Pfam | PF01031 PF00350 PF02212 |
| PROSITE | PS00410 PS51718 PS51388 |
| OMIM | 147890 |
| DisGeNET | 4600 |
National and Kapodistrian University of Athens
Department of Biology
Biophysics & Bioinformatics Laboratory