Importin beta-like protein KAP122 - Saccharomyces cerevisiae S288C

Importin beta-like protein KAP122 (Saccharomyces cerevisiae S288C)

FASTA TEXT XML

Subcellular Location Biology & Function Interactions Cross-References

General Information

Protein Information
Protein Name	Importin beta-like protein KAP122
Accession Code	P32767
Gene	KAP122
Organism	Saccharomyces cerevisiae S288C (Taxonomy: 559292)
Part of Reference Proteome?	Yes
Sequence (Length: 1081)
MSSIHEVVALIEELYSPHPKHDVNQIQQSLQSIQKSEQGFHLANELLSDDKYSANVKYFGALTLTVQLNTRGENDYETLW NVFRSNLLYLTKFSTLYVSNPNMYGQSLIIIKKLMSNLSLIFTKINDPQLNNAGNENMIKQWNNPINTFIQLMSVQNQNI NADQLLLDSINCSLTYEQLSQFVSLSQKHNELALTFTEVIVEDLTKFQTKRHSMSQIHEVVHEHLYISTMALINLNLTAQ AVFNPTVFDCITAWINYISLTRSVSSSGRMDLSEIFQNLIDLMYQSTEGSDGYENAEKILTIFGNVFANDPLLMSYDLRQ QIECIFLGVVRPDSGITDISNKNSWMLQYMNYLVTNDFFSELKELAICIVDFLQINTLSVCNKLFTNIQAADNGQVQDEY IQEYIKVLLQMTNFPLTPVLQEFFSVRMVDFWLDLSDAYTNLASETLRPNSIELSTQIFQQLINIYLPKISLSVKQRIIE EEGESTSVNEFEDFRNAVSDLAQSLWSILGNDNLTNVLIDGMGQMPAASDETLIIKDTDVLFRIETMCFVLNTILVDMTL SESPWIKNIVDANKFFNQNVISVFQTGFQTSASTKVSQILKLDFVRTSTTLIGTLAGYFKQEPFQLNPYVEALFQGLHTC TNFTSKNEQEKISNDKLEVMVIKTVSTLCETCREELTPYLMHFISFLNTVIMPDSNVSHFTRTKLVRSIGYVVQCQVSNG PEEQAKYILQLTNLLSGSIEHCLASSVQLQEQQDYINCLLYCISELATSLIQPTEIIENDALLQRLSEFQSFWSSDPLQI RSKIMCTIDKVLDNSIYCKNSAFVEIGCLIVGKGLNLPDGEPYFLKYNMSEVMNFVLRHVPNCELATCLPYFVYLLEKLI SEFRKELTPQEFDFMFEKILLVYYDAYIINDPDLLQMTIGFVNNVLDVKPGLAIGSKHWTSFILPQFLKLIPSREKFTIV AVAKFWTKLINNKKYNQEELTTVRQQVSSIGGDLVYQIMYGLFHTQRSDLNSYTDLLRALVAKFPIEAREWLVAVLPQIC NNPAGHEKFINKLLITRGSRAAGNVILQWWLDCTTLPNYQG

Structure Viewer (PDB: 6Q84)

Subcellular Location

Description
Nucleus envelope {Experimental EvidencePubMed:10525531, Experimental EvidencePubMed:10617640}.
Position in the Nuclear Envelope
Location	Location ID	Description
Nuclear Envelope	SL-0178	The nuclear envelope is a membrane system which surrounds the nucleoplasm of eukaryotic cells. It is composed of the nuclear lamina, nuclear pore complexes and two nuclear membranes. The space between the two membranes is called the nuclear intermembrane space.
Membrane Topology
Topology	Source	Annotation Type
Unknown	UniProt	Sequence Analysis
Assigned Ontology terms

Cellular Component	Cytoplasm (GO:0005737) Nuclear Envelope (GO:0005635) Nucleus (GO:0005634)

Biology & Function

Description
Nuclear transport factor (karyopherin) involved in protein transport between the cytoplasm and nucleoplasm. Required for the nuclear import of the complex composed the large subunit (TOA1) and the small subunit (TOA2) of the general transcription factor IIA (TFIIA). Required for the nuclear import of the RNR2-RNR4 heterodimer, also called beta-beta' subunit, which corresponds to the small subunit of the ribonucleotide reductase (RNR). May play a role in regulation of pleiotropic drug resistance. {Experimental EvidencePubMed:10525531, Experimental EvidencePubMed:16432237, Experimental EvidencePubMed:1882553, Experimental EvidencePubMed:18838542}.
Assigned Ontology terms

Biological Process	Protein Import Into Nucleus (GO:0006606) Regulation Of Cell Size (GO:0008361)
Molecular Function	Nuclear Import Signal Receptor Activity (GO:0061608)

Protein-Protein Interactions

Interactions with Nuclear Envelope proteins (1 interactors)

Partner (NucEnvDB)		IntAct	Confidence score
P25491	Mitochondrial protein import protein MAS5	EBI-3764975	0.35
Interactions with other proteins (22 interactors)

Partner (UniProt)		IntAct	Confidence score
P16140	V-type proton ATPase subunit B (V-ATPase subunit B) (V-ATPase 57 kDa subunit) (Vacuolar proton pump subunit B)	EBI-800949	0.35
P07259	Protein URA2 [Includes: Glutamine-dependent carbamoyl-phosphate synthase (EC 6.3.5.5); Aspartate carbamoyltransferase (EC 2.1.3.2)]	EBI-800949	0.35
P09734	Tubulin alpha-3 chain (EC 3.6.5.-)	EBI-800949	0.35
P02557	Tubulin beta chain (Beta-tubulin)	EBI-800949	0.35
P02994	Elongation factor 1-alpha (EF-1-alpha) (Eukaryotic elongation factor 1A) (eEF1A) (Translation elongation factor 1A)	EBI-800949	0.35
P11484	Ribosome-associated molecular chaperone SSB1 (EC 3.6.4.10) (Cold-inducible protein YG101) (Heat shock protein SSB1) (Hsp70 chaperone Ssb)	EBI-800949	0.35
P10592	Heat shock protein SSA2	EBI-800949	0.35
Q04062	26S proteasome regulatory subunit RPN9 (Proteasome non-ATPase subunit 7)	EBI-800949	0.35
P41940	Mannose-1-phosphate guanyltransferase (EC 2.7.7.13) (ATP-mannose-1-phosphate guanylyltransferase) (GDP-mannose pyrophosphorylase) (NDP-hexose pyrophosphorylase)	EBI-800949	0.35
P40495	Homoisocitrate dehydrogenase, mitochondrial (HIcDH) (EC 1.1.1.87)	EBI-800949	0.35
P00549	Pyruvate kinase 1 (PK 1) (EC 2.7.1.40) (cell division cycle protein 19)	EBI-800949	0.35
P00830	ATP synthase subunit beta, mitochondrial (EC 7.1.2.2)	EBI-800949	0.44
P50085	Prohibitin-2	EBI-810540	0.35
P39925	Mitochondrial respiratory chain complexes assembly protein AFG3 (EC 3.4.24.-) (ATPase family gene 3 protein) (Tat-binding homolog 10)	EBI-812746	0.27
Q00955	Acetyl-CoA carboxylase (ACC) (EC 6.4.1.2) (Fatty acid synthetase 3) (mRNA transport-defective protein 7) [Includes: Biotin carboxylase (EC 6.3.4.14)]	EBI-814773	0.27
Q06625	Glycogen debranching enzyme (Glycogen debrancher) [Includes: 4-alpha-glucanotransferase (EC 2.4.1.25) (Oligo-1,4-1,4-glucantransferase); Amylo-alpha-1,6-glucosidase (Amylo-1,6-glucosidase) (EC 3.2.1.33) (Dextrin 6-alpha-D-glucosidase)]	EBI-820843	0.27
P06103	Eukaryotic translation initiation factor 3 subunit B (eIF3b) (Cell cycle regulation and translation initiation protein) (Eukaryotic translation initiation factor 3 90 kDa subunit) (eIF3 p90) (Translation initiation factor eIF3 p90 subunit)	EBI-7560214	0.40
P40019	Histone H2A.Z-specific chaperone CHZ1	EBI-8225157	0.22
Q12363	Transcriptional modulator WTM1	EBI-15565947	0.40
P38316	Ubiquitin-like protein ATG12 (Autophagy-related protein 12)	EBI-16263556	0.35
P32381	Actin-related protein 2 (Actin-like protein ARP2) (Actin-like protein 2)	EBI-16264169	0.35
P07703	DNA-directed RNA polymerases I and III subunit RPAC1 (RNA polymerases I and III subunit AC1) (C37) (DNA-directed RNA polymerases I and III 40 kDa polypeptide) (AC40) (C40)	EBI-16280355	0.35

Cross-References

Database	Links
UNIPROT	P32767 D6VUC1
PDB	6Q82 6Q83 6Q84

Importin beta-like protein KAP122 (Saccharomyces cerevisiae S288C)

General Information

Protein Information

Structure Viewer (PDB: 6Q84)

Subcellular Location

Description Show

Position in the Nuclear Envelope

Membrane Topology

Assigned Ontology terms

Biology & Function

Description Hide

Assigned Ontology terms

Protein-Protein Interactions

Interactions with Nuclear Envelope proteins (1 interactors)

Interactions with other proteins (22 interactors)

Cross-References

Database

Links

Description

Description