NucEnvDB

NucEnvDB

A database of Nuclear Envelope Proteins and their Interactions

JNK-interacting protein - Caenorhabditis elegans - NucEnvDB

JNK-interacting protein (Caenorhabditis elegans)

FASTA TEXT XML

Subcellular Location Biology & Function Interactions Cross-References

General Information

Protein Information
Protein Name	JNK-interacting protein
Accession Code	P34609
Gene	unc
Organism	Caenorhabditis elegans (Taxonomy: 6239)
Part of Reference Proteome?	Yes
Sequence (Length: 1190)
MACNLSPVNEMADSITSSTPSEIVYGGPGSPDEHRTMSDKVQTMASAIYRELETMIKVHGEDGVKTLMPLVVNVLEALDLAYLERDEQTAELEMLKEDNEQLQTQYEREKALRKQTEQKYIEIEDTLIGQ NKELDKKIESLESIMRMLELKAKNATDHASRLEEREVEQKLEFDRLHERYNTLLRTHVDHMERTKYLMGSEKFELMQNMPLPNMQLRNKMGMAASVDASSIRGVSDLISAHMTQSTTMDVNLANHITNED WQDEFSSDIEPSPRDIPQSSADALTSPITTKEPTPKREAASPKQSEEEEADETTSVDPKENNDLLGADLTDDESDWNGLGLIPRRHRPNEMLDDDDTSDDGSLGMGREVENLIKENSELLDMKNALNIVK NDLINQVDELNSENMILRDENLSRQMVSEKMQEQITKHEEEIKTLKQKLMEKENEQEEDDVPMAMRKRFTRSEMQRVLMDRNAYKEKLMELEESIKWTEMQRAKKMQQQQQNVNQKKSGGIWEFFSSLLG DSVTPPASSRGNRASSSRGKMTRSVEYIDPDMISERRAAERREQYKLVREHVKKEDGRIEAYGWSLPNVEAEVSSVPIPVCCRPLLDNEPSLKIWCATGVVLRGGRDERGQWIVGDPIYFAPASMKKTKT SNHRPELEDEIKRARNLDARESELDEWQSSSLVWVVSSNQGKSLIAVLDANNPNNIIETFPACDSHLLCIQAVSGVMEGEPEMNEEQSKKYLSGGGKIKDLPEGLDGTDLGACEWVELRKMEDSEDGVPT YCSNDMKPSPKRTRDFSISEVAPVDSSAPVKEDPLPPPANRPGGRAALPPHIRDAMSKYDGVSGQMSGALPTVWMGGQNQYIYIHSAVTAWKQCLRRIKMPDAVLSIVHYKSRIFAALANGTIAIFHRNK HGEWSDEGYHSLRVGSATSSVRSLCLVSTNIWATYKNCVVVLDAESLQIVKVFAAHPRKDSQVRNMQWVGAGVWLSIRLDSTLRLYHAHTYEHLQDVDIEPYVTKMLGTSKLDFSYMRTTALLVSNRRLW IGTGTGVIISVPFSGQLEKKIETKDSKRPAGPGGLVRVYGATSENATNDEKTNDDFIPYCNLAHAQLSFHGHKDSVKFFLGVPGASKNGEDESAEVTLRRMLIMSGGDGYIDFRIGEENEPELTGQSIRP RDMSHLIIWEVDAELPILSK

Subcellular Location

Description
Cytoplasm, perinuclear region {Experimental EvidencePubMed:10393177, Experimental EvidencePubMed:11738026}. Note=Diffusely localized throughout cell body but intensely localized in regions adjacent to nucleus and at presumptive tips of neural processes.
Position in the Nuclear Envelope
Location	Location ID	Description
Perinuclear Region	SL-0198	The perinuclear region is the cytoplasmic region just around the nucleus.
Membrane Topology
Topology	Source	Annotation Type
Unknown	UniProt	Sequence Analysis
Assigned Ontology terms

Cellular Component	Axon (GO:0030424) Axon Initial Segment (GO:0043194) Axon Terminus (GO:0043679) Cell Body (GO:0044297) Cytoplasm (GO:0005737) Perinuclear Region Of Cytoplasm (GO:0048471)

Biology & Function

Description
The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module. May function as a regulator of synaptic vesicle transport, through interactions with the JNK-signaling components and motor proteins. Binds specific components of the JNK signaling pathway namely jnk-1, jkk-1 and sek-1. Associates with components of the motor protein, kinesin-1. Pre-assembled unc-16 scaffolding complexes are then transported as a cargo of kinesin, to the required subcellular location. Regulates the retrograde transport of autophagosomes from the neurites to the cell body of AIY interneurons (PubMed:30880001). {Experimental EvidencePubMed:10393177, Experimental EvidencePubMed:11738026, Experimental EvidencePubMed:30880001}.
Assigned Ontology terms

Biological Process	Defecation (GO:0030421) Locomotion (GO:0040011) Oviposition (GO:0018991) Regulation Of JNK Cascade (GO:0046328) Sleep (GO:0030431) Synaptic Vesicle Transport (GO:0048489) Vesicle-Mediated Transport (GO:0016192)
Molecular Function	JUN Kinase Binding (GO:0008432) Kinase Binding (GO:0019900) Kinesin Binding (GO:0019894) MAP-Kinase Scaffold Activity (GO:0005078) Signaling Receptor Complex Adaptor Activity (GO:0030159)

Protein-Protein Interactions

Interactions with Nuclear Envelope proteins (1 interactors)

Partner (NucEnvDB)		IntAct	Confidence score
P46822	Kinesin light chain	EBI-2413629	0.62
Interactions with other proteins (7 interactors)

Partner (UniProt)		IntAct	Confidence score
Q5WRT0	SF4 helicase domain-containing protein	EBI-337898	0.00
H2L0F6	GEX Interacting protein	EBI-343424	0.00
P34686	F-actin-capping protein subunit beta	EBI-345569	0.00
Q93345	Uncharacterized protein	EBI-345563	0.00
Q18668	Dymeclin	EBI-345566	0.00
Q8WQG9	Stress-activated protein kinase jnk-1 (EC 2.7.11.24)	EBI-1811901	0.40
G5EDT6	Dual specificity mitogen-activated protein kinase kinase jkk-1 (MAP kinase kinase jkk-1) (EC 2.7.12.2) (JNK-1 activator kinase) (JNK kinase)	EBI-1811913	0.40

Cross-References

Database	Links
UNIPROT	P34609 A7LPE3 A7LPE4 C0P271 C7FZT6 Q95V72 S6EZN6 S6EZP3 S6F548 S6F556 S6FD02 S6FN04 S6FN08 S6FWP4 S6FWP6 U4MKU8
Pfam	PF16471 PF09744
PROSITE	PS51776 PS51777

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