NucEnvDB

NucEnvDB

A database of Nuclear Envelope Proteins and their Interactions

Nucleoporin POM152 - Saccharomyces cerevisiae S288C - NucEnvDB

Nucleoporin POM152 (Saccharomyces cerevisiae S288C)

FASTA TEXT XML

Subcellular Location Biology & Function Interactions Cross-References

General Information

Protein Information
Protein Name	Nucleoporin POM152
Accession Code	P39685
Gene	POM152
Organism	Saccharomyces cerevisiae S288C (Taxonomy: 559292)
Part of Reference Proteome?	Yes
Sequence (Length: 1337)
MEHRYNVFNDTPRGNHWMGSSVSGSPRPSYSSRPNVNTTRRFQYSDDEPAEKIRPLRSRSFKSTESNISDEKSRISERDS KDRYINGDKKVDIYSLPLISTDVLEISKQRTFAVILFLIIQCYKIYDLVILKSGLPLSGLLFKNYRFNFISKYFIIDSFF LYVLPSFNIPRLTFKPWVVYLQILAMLLLNIFISSDHEFVLISLIMTTWRKLYTKELSVTGSAINHHRIFDSSAHFKGAL TIKILPENTAMFNPLHESYCLPMDTNLFKINSIDVPIRINSTEEIEYIELEYRDLYTNSVELRSLSKKDFKIIDNPKSFL KKDQSVLKSHSNDFEEGSTIRYLAVTLQDIGFYQIKKIVDSKKLNLKIHQSHLVVPYCPIASITGTGSNDRCIGDSDNVS FEIQGVPPMKLAYSKIVNGQTFSYVDSSLQPEYFESPLQSSKSKQSFTQGELNDLKWGRNQPVNINLDSSITQDGKFAYK IDKITDGLGNVVDFTSLPEELKKRYDLSYNFNVHEVPRAALEERFDPKSPTKRSIAIVFEEIKNWISDIPYVISLSYTDA QDKSKKIMNVTTDSLTKVLQADLPGSYNLEYIESKFCPGEIVGKSNVLVTMPVAPTMEVKSFPILDQCVGQVGLNFELSF TGAPPYYYNTKIYKLENGERKLYDAKRYTSEGTRNRFSYSPPKEGNYEIVFDTVSNKLFTEPIKLEPVKEYTFKTSMRVK PSASLKLHHDLKLCLGDHSSVPVALKGQGPFTLTYDIIETFSSKRKTFEIKEIKTNEYVIKTPVFTTGGDYILSLVSIKD STGCVVGLSQPDAKIQVRRDIPSAAFNFFEPIKEAKIKHGSVTEIPLKLSGEGPFTVKFKHMDYDGNIVKEFENKFQNSY KPALKVSKEGLYQLVDIRDSSCQGNVIYRNSLYKVSFLEKPKFAIQDNHHITKVTENLFSKEEVCQGMEGTVDLALFGSP PFILEYDLMAPNGHISTKKIQVATKYASLKLPNQIPGEYITTIKAIFDGNYGESDIHFREHQSELIIKQTVHPIPDVAFA DGGKTLRACAANVDQISFLEPINLKFLQGESPFSITFSVYHESTSRTDQYTIDNIDSENFSFEKLYEGMKLGNHAITIDS VVDANGCVNSLISGPRNQILVSITDAPKIHILDPSTEYCVGDYVAYQLNGVAPFMIKYEFNGIPLKSKERSSQFVRLASE PGIISITSLQDSSSQCIVDFTNPKLKSEFDDLSLNIHPIPSVTVSQGNYVTEDIREGDQAEVIFSFEGTPPFSLTYVRTE ETDGKHGKRRSQVVETHKVTDIYSHEYKVITSLQGTYEAIEITDAYCFAKNDLFFNN

Structure Viewer (PDB: 5TVZ)

Subcellular Location

Description
Nucleus, nuclear pore complex {Experimental EvidencePubMed:10684247}. Nucleus membrane; Multi-pass membrane protein. Note=Central core structure of the nuclear pore complex.
Position in the Nuclear Envelope
Location	Location ID	Description
Nuclear Envelope	SL-0178	The nuclear envelope is a membrane system which surrounds the nucleoplasm of eukaryotic cells. It is composed of the nuclear lamina, nuclear pore complexes and two nuclear membranes. The space between the two membranes is called the nuclear intermembrane space.
Nuclear Membrane	SL-0182	The membrane surrounding the nucleus. This term is used when it is not known if the protein is found in or associated with the inner or outer nuclear membrane.
Nuclear Pore Complex	SL-0185	The nuclear pore complex (NPC) constitutes the exclusive means of nucleocytoplasmic transport. NPCs allow the passive diffusion of ions and small molecules and the active bidirectional transport of macromolecules such as proteins, RNAs etc across the double-membrane nuclear envelope.The NPC is composed of at least 30 distinct subunits known as Nucleoporins (NUPs).
Membrane Topology
Topology	Source	Annotation Type
Transmembrane	UniProt	Sequence Analysis {ECO:0000255}
Assigned Ontology terms

Cellular Component	Cell Periphery (GO:0071944) Mitochondrion (GO:0005739) Nuclear Envelope (GO:0005635) Nuclear Envelope Lumen (GO:0005641) Nuclear Membrane (GO:0031965) Nuclear Periphery (GO:0034399) Nuclear Pore (GO:0005643) Nuclear Pore Transmembrane Ring (GO:0070762)

Biology & Function

Description
Functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. POM152 is important for the de novo assembly of NPCs. {Experimental EvidencePubMed:10684247, Experimental EvidencePubMed:11352933, Experimental EvidencePubMed:8682855, Experimental EvidencePubMed:9988776}.
Assigned Ontology terms

Biological Process	MRNA Transport (GO:0051028) Nuclear Pore Organization (GO:0006999) Nucleocytoplasmic Transport (GO:0006913) Protein Import Into Nucleus (GO:0006606) Spindle Pole Body Duplication (GO:0030474)
Molecular Function	Protein-Membrane Adaptor Activity (GO:0043495) Structural Constituent Of Nuclear Pore (GO:0017056)

Protein-Protein Interactions

Interactions with Nuclear Envelope proteins (2 interactors)

Partner (NucEnvDB)		IntAct	Confidence score
P40358	DnaJ-like chaperone JEM1	EBI-3657572	0.35
Q03790	Nucleoporin NUP53	EBI-390975	0.37
Interactions with other proteins (11 interactors)

Partner (UniProt)		IntAct	Confidence score
P47042	Probable serine/threonine-protein kinase IKS1 (EC 2.7.11.1) (IRA1 kinase suppressor 1)	EBI-390972	0.37
P38305	Altered inheritance of mitochondria protein 4 (Synthetic with old yellow enzyme protein 1)	EBI-761900	0.40
P02994	Elongation factor 1-alpha (EF-1-alpha) (Eukaryotic elongation factor 1A) (eEF1A) (Translation elongation factor 1A)	EBI-804163	0.40
Q12158	Sister chromatid cohesion protein 1	EBI-821936	0.35
P10591	Heat shock protein SSA1 (Heat shock protein YG100)	EBI-3674542	0.35
P11484	Ribosome-associated molecular chaperone SSB1 (EC 3.6.4.10) (Cold-inducible protein YG101) (Heat shock protein SSB1) (Hsp70 chaperone Ssb)	EBI-3692806	0.35
P15108	ATP-dependent molecular chaperone HSC82 (82 kDa heat shock cognate protein) (Heat shock protein Hsp90 constitutive isoform)	EBI-3734723	0.35
P10592	Heat shock protein SSA2	EBI-3756439	0.35
P32589	Heat shock protein homolog SSE1 (Chaperone protein MSI3)	EBI-3757151	0.35
P39102	DnaJ protein homolog XDJ1	EBI-3761596	0.35
P39078	T-complex protein 1 subunit delta (TCP-1-delta) (CCT-delta)	EBI-3822546	0.35

Cross-References

Database	Links
UNIPROT	P39685 D6VZV2
PDB	5TVZ

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