NucEnvDB

NucEnvDB

A database of Nuclear Envelope Proteins and their Interactions

Ran GTPase-activating protein 1 - Schizosaccharomyces pombe 972h- - NucEnvDB

Ran GTPase-activating protein 1 (Schizosaccharomyces pombe 972h-)

FASTA TEXT XML

Subcellular Location Biology & Function Interactions Cross-References

General Information

Protein Information
Protein Name	Ran GTPase-activating protein 1
Accession Code	P41391
Gene	rna1
Organism	Schizosaccharomyces pombe 972h- (Taxonomy: 284812)
Part of Reference Proteome?	Yes
Sequence (Length: 386)
MSRFSIEGKSLKLDAITTEDEKSVFAVLLEDDSVKEIVLSGNTIGTEAARWLSENIASKKDLEIAEFSDIFTGRVKDEIP EALRLLLQALLKCPKLHTVRLSDNAFGPTAQEPLIDFLSKHTPLEHLYLHNNGLGPQAGAKIARALQELAVNKKAKNAPP LRSIICGRNRLENGSMKEWAKTFQSHRLLHTVKMVQNGIRPEGIEHLLLEGLAYCQELKVLDLQDNTFTHLGSSALAIAL KSWPNLRELGLNDCLLSARGAAAVVDAFSKLENIGLQTLRLQYNEIELDAVRTLKTVIDEKMPDLLFLELNGNRFSEEDD VVDEIREVFSTRGRGELDELDDMEELTDEEEEDEEEEAESQSPEPETSEEEKEDKELADELSKAHI

Structure Viewer (PDB: 2CA6)

Subcellular Location

Description
Cytoplasm. Cytoplasm, perinuclear region {Curator Inference}. Note=Possibly enriched in the nuclear periphery.
Position in the Nuclear Envelope
Location	Location ID	Description
Perinuclear Region	SL-0198	The perinuclear region is the cytoplasmic region just around the nucleus.
Membrane Topology
Topology	Source	Annotation Type
Unknown	UniProt	Sequence Analysis
Assigned Ontology terms

Cellular Component	Cytoplasm (GO:0005737) Cytosol (GO:0005829) Nuclear Membrane (GO:0031965) Nucleus (GO:0005634) Perinuclear Region Of Cytoplasm (GO:0048471)

Biology & Function

Description
GTPase activator for the nuclear Ras-related regulatory protein spi1 (Ran), converting it to the putatively inactive GDP-bound state.
Assigned Ontology terms

Biological Process	Activation Of GTPase Activity (GO:0090630) Nucleocytoplasmic Transport (GO:0006913) Positive Regulation Of Protein Export From Nucleus (GO:0046827)
Molecular Function	GTPase Activator Activity (GO:0005096) Small GTPase Binding (GO:0031267)

Protein-Protein Interactions

Interactions with Nuclear Envelope proteins (1 interactors)

Partner (NucEnvDB)		IntAct	Confidence score
P62826	GTP-binding nuclear protein Ran	EBI-1032926	0.40

Cross-References

Database	Links
UNIPROT	P41391
PDB	1K5D 1K5G 1YRG 2CA6

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