NucEnvDB

NucEnvDB

A database of Nuclear Envelope Proteins and their Interactions

Signal-induced proliferation-associated protein 1 - Mus musculus - NucEnvDB

Signal-induced proliferation-associated protein 1 (Mus musculus)

FASTA TEXT XML

Subcellular Location Biology & Function Interactions Cross-References

General Information

Protein Information
Protein Name	Signal-induced proliferation-associated protein 1
Accession Code	P46062
Gene	Sipa1
Organism	Mus musculus \| House mouse (Taxonomy: 10090)
Part of Reference Proteome?	Yes
Sequence (Length: 1037)
MWAGGVGSPRRGMAPAPTDDLFARKLRQPARPPLTPNTFEPRPARGPLLRSGSDAGEVRPPTPASPRARAHSHEDASRPAATPTRLFTDPLALLGLPAEEPEPTFPPVLEPRWFAHYDVQSLLFDWAPRP RGTGSHTEANSGTLAEGQTTTSDLLLGAPGFVSELGGEGELGLGGPISPPVPPALPNAAVSVLEEPQTRTTTYSLEHADLGAGYYRKYFYGKEHQNFFGLDEALGPVAVSLRREEKEGSGGGTLHSYRVI VRTTQLRTLRGTISEDALPPGPPSVSPRKLLEHVAPRLSPTCLRLGSASPKVPRQLLTLDEQVLSFQRKGGILYCRAGQGSEEEMYNNQEAGAAFMQFLTLLGDVVRLKGFESYRAQLDTKTDSTGTHSL YTTYQDHEIMFHVSTMLPYTPNNQQQLLRKRHIGNDIVTIVFQEPGSKPFCPTTIRSHFQHVFLVVRAHAPCTPHTSYRVAVSRTQDTPAFGPALPEGGGPFAANADFRAFLLAKALNGEQAAGHARQFH AMATRTRQQYLQDLATNEVTTTSLDSASRFGLPSLGGRRRATPRSPGADVQAAGALMWGVRAAPGARVAAGAETSGPDDAEVPCLLGISAETLVLVAPRDGRVVFNCACRDVLAWTFSEHQLDLYHGRGE AITLRLDGAPGQAVGEVVARLQLVSRGCETRELALPRDGQGRLGFEVDAEGFITHVERFTFAETTGLRPGARLLRVCGQTLPKLGPETAAQMLRSAPKVCVTVLPPDESGRPRRSFSELYMLSLKEPSRR GGPEPVQDETGKLVILPPTKQLLHFCLKDSSSPPGPGDLTEERTEFLRTHNSLSSGSSLSDEAPVLPNTTPDLLLVTTANPSAPGTDRETPPSQDQSGSPSSHEDTSDSGPELRASILPRTLSLRNSISK IMSEAGSETLEDEWQSISEIASTCNTILESLSREGQPISESGDPKEALKCDSEPEPGSLSEKVSHLESMLWKLQEDLQREKADRAALEEEVRSLRHNNQRLLAESESAATRLLLASKHLGAPTTDLA

Subcellular Location

Description
Nucleus {Experimental EvidencePubMed:7799964}. Cytoplasm, perinuclear region {By SimilarityUniProtKB:Q96FS4}. Endomembrane system; Peripheral membrane protein {By SimilarityUniProtKB:Q96FS4}. Note=Mostly localized in the perinuclear membraneous region. {By SimilarityUniProtKB:Q96FS4}.
Position in the Nuclear Envelope
Location	Location ID	Description
Perinuclear Region	SL-0198	The perinuclear region is the cytoplasmic region just around the nucleus.
Membrane Topology
Topology	Source	Annotation Type
Peripheral	UniProt	By Similarity {ECO:0000250\|UniProtKB:Q96FS4}
Assigned Ontology terms

Cellular Component	Cytoplasm (GO:0005737) Membrane (GO:0016020) Nucleus (GO:0005634) Perinuclear Region Of Cytoplasm (GO:0048471) Protein-Containing Complex (GO:0032991) Transport Vesicle (GO:0030133)

Biology & Function

Description
GTPase activator for the nuclear Ras-related regulatory proteins Rap1, Rsr1 and Ran in vitro, converting them to the putatively inactive GDP-bound state. Affects cell cycle progression. {Experimental EvidencePubMed:7799964}.
Assigned Ontology terms

Biological Process	Activation Of GTPase Activity (GO:0090630) Cellular Response To Water Deprivation (GO:0042631) Regulation Of Cell Cycle (GO:0051726) Regulation Of Small GTPase Mediated Signal Transduction (GO:0051056)
Molecular Function	GTPase Activator Activity (GO:0005096) Protein C-Terminus Binding (GO:0008022)

Protein-Protein Interactions

Interactions with other proteins (2 interactors)

Partner (UniProt)		IntAct	Confidence score
Q4U2R1	E3 ubiquitin-protein ligase HERC2 (EC 2.3.2.26) (HECT domain and RCC1-like domain-containing protein 2) (HECT-type E3 ubiquitin transferase HERC2)	EBI-16730475	0.35
Q7TPH6	E3 ubiquitin-protein ligase MYCBP2 (EC 2.3.2.33) (Myc-binding protein 2) (Pam/highwire/rpm-1 protein) (Protein Magellan) (Protein associated with Myc)	EBI-16731507	0.35

Cross-References

Database	Links
UNIPROT	P46062 P70204
Pfam	PF00595 PF02145
PROSITE	PS50106 PS50085

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