NucEnvDB

NucEnvDB

A database of Nuclear Envelope Proteins and their Interactions

Importin subunit beta - Xenopus laevis - NucEnvDB

Importin subunit beta (Xenopus laevis)

FASTA TEXT XML

Subcellular Location Biology & Function Interactions Cross-References

General Information

Protein Information
Protein Name	Importin subunit beta
Accession Code	P52297
Gene	kpnb1
Organism	Xenopus laevis \| African clawed frog (Taxonomy: 8355)
Part of Reference Proteome?	Yes
Sequence (Length: 876)
MELVTILEKTVSPDRNELEAAQKFLEQAAVENLPTFVVELSKVLANPANSQVARVAAGLQIKNPLTSRDPDVKAQYQQRWLAIDASARGEIKTYVLRTLGTESYRPSSASQCVAGIACAEITVNQWPQLI PQLVANVTDPNSTERMKESTLEAIGYICQDIDPEQLQHKSNEILTAIIQGMRKEEPSNNVRLAATNALLNSLEFTKANFDKESERHYIMQVVCEATQCPDTRVRVAALQNLVKIMSLYYQYMETYMGPAL FAITVEAMKNEIDEVALQGIEFWSNVCDEEMDLAIEASEAAEQGRPPEHTSKFYAKGALQYLVPILTQTLTKQDENDDDDDWNPCKAAGVCLMLLATCCEDDIVPHVLPFIKEHIKNPDWRYRDAAVMAF GCILEGPESCQLKPLVIQAMPTLIELMKDPSVVVRDTTAWTVGRICELLPEAAINDVYLAPLLQCLIEGLGAEPRVASNVCWAFSSLAEAAYEAADVADDQEEPSSYCLSSSFEVIVQKLLETTDRPDGH QNNLRSAAYEALMEIVKNSAKDCYPAVQKTTLVIMERLQQVLQVESHIQSTSDRIQFNDLQSLLCATLQNVLRKVQHQDALQISDVVMASLLRMFQSTAGSGGVQEDALMAVSTLVEVLGAEFLKYMEAF KPFLTIGLKNYAEYQVCLAAVGLVGDLCRALQSNILPFCDEMMQFLLENLGNENVHRSVKPQILSVFGDVALAIGGEFKKYLDVVLNTLQQASQAQVDKSDYDMVDYLNELREGCIEAYTGIIQGLKGDQ ENVHPDVMLVQPRVEFILSFIDHIAGDEDHTDSVVACGAGLIGDLCTAFGKDVLKLVEARPMIHELLTEGRRSKTNKTKTLATWATKELRKLKNQA

Subcellular Location

Description
Cytoplasm {By SimilarityUniProtKB:Q14974}. Nucleus envelope {By SimilarityUniProtKB:Q14974}.
Position in the Nuclear Envelope
Location	Location ID	Description
Nuclear Envelope	SL-0178	The nuclear envelope is a membrane system which surrounds the nucleoplasm of eukaryotic cells. It is composed of the nuclear lamina, nuclear pore complexes and two nuclear membranes. The space between the two membranes is called the nuclear intermembrane space.
Membrane Topology
Topology	Source	Annotation Type
Unknown	UniProt	Sequence Analysis
Assigned Ontology terms

Cellular Component	Cytosol (GO:0005829) Nuclear Envelope (GO:0005635)

Biology & Function

Description
Required for nuclear protein import and mediates docking of import substrate to distinct nucleoporins. {Experimental EvidencePubMed:7878057}.
Assigned Ontology terms

Biological Process	Protein Import Into Nucleus (GO:0006606)
Molecular Function	Small GTPase Binding (GO:0031267)

Protein-Protein Interactions

Interactions with Nuclear Envelope proteins (2 interactors)

Partner (NucEnvDB)		IntAct	Confidence score
P20676	Nucleoporin NUP1	EBI-6285121	0.44
P62826	GTP-binding nuclear protein Ran	EBI-286729	0.35
Interactions with other proteins (8 interactors)

Partner (UniProt)		IntAct	Confidence score
P70012	Nuclear/mitotic apparatus protein (nuclear mitotic apparatus protein 1 S homeolog)	EBI-7780729	0.44
Q7ZZY7	Rae1 protein homolog (mRNA-associated protein mrnp 41)	EBI-618939	0.63
Q5EWX9	Nuclear pore protein pom121 (nuclear envelope pore membrane protein POM 121)	EBI-8070373	0.50
A5XAW2	Kinesin-like protein	EBI-3511241	0.35
A0A1L8G4G8	vigilin	EBI-3645151	0.35
Q6PAY1	MGC68541 protein (nucleoporin 54kDa S homeolog)	EBI-6285093	0.35
Q91349	IL4I1 protein (Nuclear pore complex glycoprotein p62) (nucleoporin 62kDa L homeolog)	EBI-6285081	0.35
Q6DCP4	Nup98 protein	EBI-6285109	0.44

Cross-References

Database	Links
UNIPROT	P52297 B0LM40
Pfam	PF03810
PROSITE	PS50077 PS50166

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