NucEnvDB

NucEnvDB

A database of Nuclear Envelope Proteins and their Interactions

Neuronal calcium sensor 1 - Rattus norvegicus - NucEnvDB

Neuronal calcium sensor 1 (Rattus norvegicus)

FASTA TEXT XML

Subcellular Location Biology & Function Interactions Cross-References

General Information

Protein Information
Protein Name	Neuronal calcium sensor 1
Accession Code	P62168
Gene	Ncs1
Organism	Rattus norvegicus \| Norway rat (Taxonomy: 10116)
Part of Reference Proteome?	Yes
Sequence (Length: 190)
MGKSNSKLKPEVVEELTRKTYFTEKEVQQWYKGFIKDCPSGQLDAAGFQKIYKQFFPFGDPTKFATFVFNVFDENKDGRI EFSEFIQALSVTSRGTLDEKLRWAFKLYDLDNDGYITRNEMLDIVDAIYQMVGNTVELPEEENTPEKRVDRIFAMMDKNA DGKLTLQEFQEGSKADPSIVQALSLYDGLV

Structure Viewer (PDB: 4YRU)

Subcellular Location

Description
Golgi apparatus {Experimental EvidencePubMed:11526106}. Postsynaptic density {Curator Inference}. Cytoplasm, perinuclear region {By SimilarityUniProtKB:P62166}. Cytoplasm {Experimental EvidencePubMed:11526106}. Cell membrane {Experimental EvidencePubMed:11526106}. Membrane {By SimilarityUniProtKB:P62166, ECO:0000269\|PubMed:10514519}; Lipid-anchor {By SimilarityUniProtKB:P62166}. Note=Associated with Golgi stacks. Post-synaptic densities of dendrites, and in the pre-synaptic nerve terminal at neuromuscular junctions. {By SimilarityUniProtKB:P62166, Experimental EvidencePubMed:11526106, Curator Inference}.
Position in the Nuclear Envelope
Location	Location ID	Description
Perinuclear Region	SL-0198	The perinuclear region is the cytoplasmic region just around the nucleus.
Membrane Topology
Topology	Source	Annotation Type
Lipid-Anchored	UniProt	Experimental Evidence {ECO:0000269\|PubMed:10514519}
Assigned Ontology terms

Cellular Component	Anchoring Junction (GO:0070161) Axon (GO:0030424) Calyx Of Held (GO:0044305) Cytoplasm (GO:0005737) Cytoplasmic Vesicle (GO:0031410) Cytosol (GO:0005829) Dendrite (GO:0030425) Glutamatergic Synapse (GO:0098978) Golgi Apparatus (GO:0005794) Perinuclear Region Of Cytoplasm (GO:0048471) Plasma Membrane (GO:0005886) Postsynapse (GO:0098794) Postsynaptic Cytosol (GO:0099524) Postsynaptic Density (GO:0014069) Presynaptic Cytosol (GO:0099523)

Biology & Function

Description
Neuronal calcium sensor, regulator of G protein-coupled receptor phosphorylation in a calcium dependent manner. Directly regulates GRK1 (RHOK), but not GRK2 to GRK5. Can substitute for calmodulin. Stimulates PI4KB kinase activity. Involved in long-term synaptic plasticity through its interaction with PICK1. May also play a role in neuron differentiation through inhibition of the activity of N- type voltage-gated calcium channel. {Experimental EvidencePubMed:17502602}.
Assigned Ontology terms

Biological Process	Phosphatidylinositol-Mediated Signaling (GO:0048015) Positive Regulation Of Exocytosis (GO:0045921) Regulation Of Neuron Projection Development (GO:0010975) Regulation Of Synaptic Vesicle Exocytosis (GO:2000300)
Molecular Function	Calcium Ion Binding (GO:0005509) Calcium Sensitive Guanylate Cyclase Activator Activity (GO:0008048) Calcium-Dependent Protein Kinase Inhibitor Activity (GO:0008427) Magnesium Ion Binding (GO:0000287) Protein Kinase Binding (GO:0019901) Voltage-Gated Calcium Channel Activity (GO:0005245) Voltage-Gated Calcium Channel Activity Involved In Regulation Of Presynaptic Cytosolic Calcium Levels (GO:0099626)

Protein-Protein Interactions

Interactions with other proteins (7 interactors)

Partner (UniProt)		IntAct	Confidence score
P14100	Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A (Cam-PDE 1A) (EC 3.1.4.17) (61 kDa Cam-PDE)	EBI-907835	0.50
P84080	ADP-ribosylation factor 1 (EC 3.6.5.2)	EBI-907835	0.50
P00829	ATP synthase subunit beta, mitochondrial (EC 7.1.2.2) (ATP synthase F1 subunit beta)	EBI-907835	0.35
Q28115	Glial fibrillary acidic protein (GFAP)	EBI-907835	0.35
P19120	Heat shock cognate 71 kDa protein (EC 3.6.4.10) (Heat shock 70 kDa protein 8)	EBI-907835	0.35
P20004	Aconitate hydratase, mitochondrial (Aconitase) (EC 4.2.1.3) (Citrate hydro-lyase)	EBI-907835	0.35
P19483	ATP synthase subunit alpha, mitochondrial (ATP synthase F1 subunit alpha)	EBI-907835	0.35

Cross-References

Database	Links
UNIPROT	P62168 P36610 Q9UK26
PDB	4OV2 4YRU 5AEQ 5AER 5AFP
Pfam	PF00036 PF13499
PROSITE	PS00018 PS50222

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