NucEnvDB

NucEnvDB

A database of Nuclear Envelope Proteins and their Interactions

Cyclin-G-associated kinase - Rattus norvegicus - NucEnvDB

Cyclin-G-associated kinase (Rattus norvegicus)

FASTA TEXT XML

Subcellular Location Biology & Function Interactions Cross-References

General Information

Protein Information
Protein Name	Cyclin-G-associated kinase
Accession Code	P97874
Gene	Gak
Organism	Rattus norvegicus \| Norway rat (Taxonomy: 10116)
Part of Reference Proteome?	Yes
Sequence (Length: 1305)
MSLLQSALDFLAGPGSLGGAAGRDQSDFVGQTVELGELRLRVRRVLAEGGFAFVYEAQDLGSGREYALKRLLSNEEEKNRAIIQEVCFLKKLSGHPNIVQFCSAASIGKEESDTGQAEFLLLTELCKGQL VEFLRRVECKGPLSCDSILKIFYQTCRAVQHMHRQKPPIIHRDLKVENLLLSNQGTIKLCDFGSATTISHYPDYSWSAQKRAMVEEEITRNTTPMYRTPEIVDLYSNFPIGEKQDIWALGCILYLLCFRQ HPFEDGAKLRIVNGKYSIPVNDTRYTVFHDLIRGMLKVNPEERLSIAEVVRQLQEIAAARNVNPKAPITELLEQNGGYGNSGPSRAQPPSGGPVNSSGVLALAEYDQPYGGFLDILRGGTERLFTNLKDT SSKVIQSVANYAKGDLDISYITSRIAVMSFPAEGVESAIKNNIEDVRLFLDAKHPGHYAVYNLSPRIYRASKFHNRVTECGWAVRRAPHLHSLYTLCRSMHAWLREDHRNVCVVHCMDGRAASAVAVCAF LCFCRLFSTAEAAVYMFSMKRCPPGIWPSHKRYIEYVCDMVAEEPITPHSKPMLVKSVVMTPVPLFSKQRNGCRPFCEVYVGEERVTTTSQEYDRMKEFKIEDGKAVIPLGITVQGDVLTIIYHARSTLG GRLQAKMASMKMFQIQFHTGFVPRNATTVKFAKYDLDACDIQEKYPDLFQVNLEVEVEPRDRPSRDVPPWENTSLRGLNPKILFSNREEQQDILSKFGKPELPRQPGSTAQYDAEAGSPEAEITESDSPQ SSSTDTNHFLHTLDWQEEKDPETGVDNTSPKESQSNLIADGDGSEVSDEEEASCPSEERKPGAGEDTPRLAAGTRQQDLIFDVGMLAAPQEPVQPEEGVDLLGLHSEGDLRPAAPLQASGVQSSNTDLLS SLLEPSDASQVGPPGDLLGGETPLLLASPVSLLGVQSNLQGKVPDTVDPFDQFLLPSSSDTQPCSKPDLFGEFLNSDSVASSTAFPSTHSAPPPSCSTAFLHLGDLPAEPNKVIASSSHPDLLGGWDTWA ETALPGPASMPVPEGTLFSSAGHPAPPGPNPSQTKSQNPDPFADLSDLSSSLQGLPAGLPAGSFVGTSATTHKSNSSWQTTRPTAPGTSWPPQAKPAPRASEQLRSHFSVIGAREERGVRAPSFAQKPKV SENDFEDLLPNQGFSKSDKKGPKTMAEMRKQELARDTDPFKLKLLDWIEGKERNIRALLSTLHTVLWDGESRWTPVSMADLVTPEQVKKQYRRAVLVVHPDKATGQPYEQSAKMIFMELNDAWSEFENQG SRPLF

Subcellular Location

Description
Cytoplasm, perinuclear region {By Similarity}. Golgi apparatus, trans-Golgi network {By Similarity}. Cell junction, focal adhesion {By Similarity}. Note=Localizes to the perinuclear area and to the trans-Golgi network. Also seen on the plasma membrane, probably at focal adhesions (By similarity). {By Similarity}.
Position in the Nuclear Envelope
Location	Location ID	Description
Perinuclear Region	SL-0198	The perinuclear region is the cytoplasmic region just around the nucleus.
Membrane Topology
Topology	Source	Annotation Type
Unknown	UniProt	Sequence Analysis
Assigned Ontology terms

Cellular Component	Cytoplasm (GO:0005737) Cytosol (GO:0005829) Focal Adhesion (GO:0005925) Golgi Apparatus (GO:0005794) Intracellular Membrane-Bounded Organelle (GO:0043231) Perinuclear Region Of Cytoplasm (GO:0048471) Vesicle (GO:0031982)

Biology & Function

Description
Associates with cyclin G and CDK5. Seems to act as an auxilin homolog that is involved in the uncoating of clathrin-coated vesicles by Hsc70 in non-neuronal cells. Expression oscillates slightly during the cell cycle, peaking at G1 (By similarity). {By Similarity}.
Assigned Ontology terms

Biological Process	Cell Cycle (GO:0007049) Cell Development (GO:0048468) Clathrin Coat Disassembly (GO:0072318) Clathrin-Coated Pit Assembly (GO:1905224) Clathrin-Dependent Endocytosis (GO:0072583) Endoplasmic Reticulum Organization (GO:0007029) Epidermal Cell Differentiation (GO:0009913) Epithelial Cell Development (GO:0002064) Establishment Of Skin Barrier (GO:0061436) Forebrain Morphogenesis (GO:0048853) Golgi Organization (GO:0007030) Golgi To Lysosome Transport (GO:0090160) Intrahepatic Bile Duct Development (GO:0035622) Keratinocyte Differentiation (GO:0030216) Negative Regulation Of Neuron Projection Development (GO:0010977) Neural Precursor Cell Proliferation (GO:0061351) Neuroepithelial Cell Differentiation (GO:0060563) Positive Regulation Of Neural Precursor Cell Proliferation (GO:2000179) Positive Regulation Of Stem Cell Proliferation (GO:2000648) Protein Localization To Golgi Apparatus (GO:0034067) Protein Localization To Plasma Membrane (GO:0072659) Protein Phosphorylation (GO:0006468) Receptor-Mediated Endocytosis (GO:0006898) Stem Cell Differentiation (GO:0048863) Stem Cell Proliferation (GO:0072089)
Molecular Function	ATP Binding (GO:0005524) Clathrin Binding (GO:0030276) Cyclin Binding (GO:0030332) Protein Serine Kinase Activity (GO:0106310) Protein Serine/Threonine Kinase Activity (GO:0004674)

Protein-Protein Interactions

Interactions with other proteins (2 interactors)

Partner (UniProt)		IntAct	Confidence score
P39052	Dynamin-2 (EC 3.6.5.5)	EBI-6947872	0.38
Q5XIE8	Integral membrane protein 2B (Immature BRI2) (imBRI2) (Transmembrane protein BRI) (Bri) [Cleaved into: BRI2, membrane form (Mature BRI2) (mBRI2); BRI2 intracellular domain (BRI2 ICD); BRI2C, soluble form; Bri23 peptide (Bri2-23) (ABri23) (C-terminal peptide) (P23 peptide)]	EBI-26440627	0.35

Cross-References

Database	Links
UNIPROT	P97874
Pfam	PF00226 PF00069 PF10409
PROSITE	PS51182 PS50076 PS51181 PS50011 PS00108

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