National and Kapodistrian University of Athens
Department of Biology
Biophysics & Bioinformatics Laboratory
Protein Information |
|
|---|---|
| Protein Name | Processed inositol 1,4,5-triphosphate receptor associated 2 |
| Accession Code | Q12912 |
| Gene | IRAG2 |
| Organism | Homo sapiens | Human (Taxonomy: 9606) |
| Part of Reference Proteome? | Yes |
| Sequence (Length: 555) |
Description |
Position in the Nuclear Envelope |
|
|---|---|---|
| Location | Location ID | Description |
| Nuclear Envelope | SL-0178 | The nuclear envelope is a membrane system which surrounds the nucleoplasm of eukaryotic cells. It is composed of the nuclear lamina, nuclear pore complexes and two nuclear membranes. The space between the two membranes is called the nuclear intermembrane space. | Membrane Topology |
| Topology | Source | Annotation Type |
| Transmembrane | UniProt | Sequence Analysis {ECO:0000255} | Assigned Ontology terms |
Description |
|
|---|---|
| Plays a role in the delivery of peptides to major histocompatibility complex (MHC) class I molecules; this occurs in a transporter associated with antigen processing (TAP)-independent manner. May play a role in taste signal transduction via ITPR3. May play a role during fertilization in pronucleus congression and fusion. Plays a role in maintaining nuclear shape, maybe as a component of the LINC complex and through interaction with microtubules. {By SimilarityUniProtKB:Q60664}. | Assigned Ontology terms |
Interactions with other proteins (8 interactors) |
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|---|---|---|---|
Database | Links |
| UNIPROT | Q12912 A0AVM2 B4E077 Q8N301 |
| Pfam | PF05781 |
| OMIM | 602003 |
| DisGeNET | 4033 |
National and Kapodistrian University of Athens
Department of Biology
Biophysics & Bioinformatics Laboratory