NucEnvDB

NucEnvDB

A database of Nuclear Envelope Proteins and their Interactions

Ras GTPase-activating protein 2 - Homo sapiens - NucEnvDB

Ras GTPase-activating protein 2 (Homo sapiens)

FASTA TEXT XML

Subcellular Location Biology & Function Cross-References

General Information

Protein Information
Protein Name	Ras GTPase-activating protein 2
Accession Code	Q15283
Gene	RASA2
Organism	Homo sapiens \| Human (Taxonomy: 9606)
Part of Reference Proteome?	Yes
Sequence (Length: 850)
MAAAAPAAAAASSEAPAASATAEPEAGDQDSREVRVLQSLRGKICEAKNLLPYLGPHKMRDCFCTINLDQEEVYRTQVVEKSLSPFFSEEFYFEIPRTFQYLSFYVYDKNVLQRDLRIGKVAIKKEDLCN HSGKETWFSLQPVDSNSEVQGKVHLELKLNELITENGTVCQQLVVHIKACHGLPLINGQSCDPYATVSLVGPSRNDQKKTKVKKKTSNPQFNEIFYFEVTRSSSYTRKSQFQVEEEDIEKLEIRIDLWNN GNLVQDVFLGEIKVPVNVLRTDSSHQAWYLLQPRDNGNKSSKTDDLGSLRLNICYTEDYVLPSEYYGPLKTLLLKSPDVQPISASAAYILSEICRDKNDAVLPLVRLLLHHDKLVPFATAVAELDLKDTQ DANTIFRGNSLATRCLDEMMKIVGGHYLKVTLKPILDEICDSSKSCEIDPIKLKEGDNVENNKENLRYYVDKLFNTIVKSSMSCPTVMCDIFYSLRQMATQRFPNDPHVQYSAVSSFVFLRFFAVAVVSP HTFHLRPHHPDAQTIRTLTLISKTIQTLGSWGSLSKSKSSFKETFMCEFFKMFQEEGYIIAVKKFLDEISSTETKESSGTSEPVHLKEGEMYKRAQGRTRIGKKNFKKRWFCLTSRELTYHKQPGSKDAI YTIPVKNILAVEKLEESSFNKKNMFQVIHTEKPLYVQANNCVEANEWIDVLCRVSRCNQNRLSFYHPSVYLNGNWLCCQETGENTLGCKPCTAGVPADIQIDIDEDRETERIYSLFTLSLLKLQKMEEAC GTIAVYQGPQKEPDDYSNFVIEDSVTTFKTIQQIKSIIEKLDEPHEKYRKKRSSSAKYGSKENPIVGKAS

Subcellular Location

Description
Cytoplasm. Cytoplasm, perinuclear region.
Position in the Nuclear Envelope
Location	Location ID	Description
Perinuclear Region	SL-0198	The perinuclear region is the cytoplasmic region just around the nucleus.
Membrane Topology
Topology	Source	Annotation Type
Unknown	UniProt	Sequence Analysis
Assigned Ontology terms

Cellular Component	Cytosol (GO:0005829) Perinuclear Region Of Cytoplasm (GO:0048471)

Biology & Function

Description
Inhibitory regulator of the Ras-cyclic AMP pathway. Binds inositol tetrakisphosphate (IP4).
Assigned Ontology terms

Biological Process	Intracellular Signal Transduction (GO:0035556) Negative Regulation Of Ras Protein Signal Transduction (GO:0046580) Regulation Of GTPase Activity (GO:0043087) Signal Transduction (GO:0007165)
Molecular Function	GTPase Activator Activity (GO:0005096) Metal Ion Binding (GO:0046872) Phospholipid Binding (GO:0005543)

Cross-References

Database	Links
UNIPROT	Q15283 A8K7K1 G3V0F9 O00695 Q15284 Q92594 Q99577 Q9UEQ2
Pfam	PF00779 PF00168 PF00169 PF00616
PROSITE	PS50004 PS50003 PS00509 PS50018 PS51113
OMIM	601589
DisGeNET	5922

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