NucEnvDB

NucEnvDB

A database of Nuclear Envelope Proteins and their Interactions

Early growth response factor homolog 1 - Caenorhabditis elegans - NucEnvDB

Early growth response factor homolog 1 (Caenorhabditis elegans)

FASTA TEXT XML

Subcellular Location Biology & Function Cross-References

General Information

Protein Information
Protein Name	Early growth response factor homolog 1
Accession Code	Q18250
Gene	egrh
Organism	Caenorhabditis elegans (Taxonomy: 6239)
Part of Reference Proteome?	Yes
Sequence (Length: 461)
MALHEPPSKLNRHSHSNLLKPPSLNKPILTFADNDCLKTPTMNDMLKTPTVNSPRHTPMNIDGTPKVNGFSGFTPQTDQKFFGEHEPLFNQMHTTTLMPAPSSSYKEPAYSSEQPSSSSDEAKPKELLGS NSFGVPRMTNGNSKQKPEELTLKDIEISSTGPGGVDSPGLSAAMFQFSPMVEHFLQNLTNKAGLPELVVDSKTAGLNHQEPSDLIKSVQVRRSSIEDQKFSDVLHVPTLPRKTSEPSHLGSSLQNEHPQS NSRPSTVIPRVQRTNTSASLTRSMDHSSMSPISAHDDPYSNSASYSSLSTHTSFSDSASLAHFEPKTEPMDDYSYNFSDNDFNSFEFSSTSEELKNIGCQKMKSSKMPLQDRPYKCPRDGCDRRFSRSDE LTRHIRIHTGQKPFQCRICMRAFSRSDHLTTHVRTHTGEKPFSCDICGRKFARSDERKRHTKVHKTSRSGS

Subcellular Location

Description
Nucleus {Experimental EvidencePubMed:20736289}. Cytoplasm, perinuclear region {Experimental EvidencePubMed:20736289}. Note=Perinuclear localization only observed in sperm. {Experimental EvidencePubMed:20736289}.
Position in the Nuclear Envelope
Location	Location ID	Description
Perinuclear Region	SL-0198	The perinuclear region is the cytoplasmic region just around the nucleus.
Membrane Topology
Topology	Source	Annotation Type
Unknown	UniProt	Sequence Analysis
Assigned Ontology terms

Cellular Component	Nucleus (GO:0005634) Perinuclear Region Of Cytoplasm (GO:0048471)

Biology & Function

Description
Sequence-specific DNA-binding transcription factor (By similarity). Plays a role in oocyte development, acting cell- autonomously in the somatic gonad (PubMed:20736289). Involved in negative regulation of oocyte MAPK activation and inhibits oocyte maturation and ovulation (PubMed:20736289). {By SimilarityUniProtKB:P11161, Experimental EvidencePubMed:20736289}.
Assigned Ontology terms

Biological Process	Negative Regulation Of MAP Kinase Activity (GO:0043407) Negative Regulation Of Oocyte Maturation (GO:1900194) Negative Regulation Of Ovulation (GO:0060280) Regulation Of Transcription By RNA Polymerase II (GO:0006357)
Molecular Function	DNA-Binding Transcription Factor Activity, RNA Polymerase II-Specific (GO:0000981) Metal Ion Binding (GO:0046872) RNA Polymerase II Cis-Regulatory Region Sequence-Specific DNA Binding (GO:0000978)

Cross-References

Database	Links
UNIPROT	Q18250
Pfam	PF00096
PROSITE	PS00028 PS50157

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