NucEnvDB

NucEnvDB

A database of Nuclear Envelope Proteins and their Interactions

Glycerophosphodiester phosphodiesterase domain-containing protein 5 - Gallus gallus - NucEnvDB

Glycerophosphodiester phosphodiesterase domain-containing protein 5 (Gallus gallus)

FASTA TEXT XML

Subcellular Location Biology & Function Interactions Cross-References

General Information

Protein Information
Protein Name	Glycerophosphodiester phosphodiesterase domain-containing protein 5
Accession Code	Q3KTM2
Gene	GDPD5
Organism	Gallus gallus \| Chicken (Taxonomy: 9031)
Part of Reference Proteome?	Yes
Sequence (Length: 599)
MVKHQPLQYYEPQLCLSCLTGIYGCRWKRYQRSHDDTTKWERLWFLILTSSFFLTLVWFYFWWEVHNDYNEINWFLYNRMGYWSDWSIPILVTTAAGFTYITVLLILALCHIAVGQQMNLHWLHKIGLMT TLITTVVTMSSIAQLWDDEWEMVFISLQATAPFLHIGALAAVTALSWLIAGQFARMEKATSQMLMVTAYLAVVVALYLVPLTISSPCIMEKKALGPKPAIIGHRGAPMLAPENTLMSFQKAVEQKIYGVQ ADVILSYDGVPFLMHDKTLRRTTNVEEVFPGRAYEHSSMFNWTDLEMLNAGEWFLRNDPFWTAGSLSRSDYLEAANQSVCKLADMLEVIKDNTSLILNFQDLPPDHPYYTSYINITLKTILASGIQQQAV MWLPDTERQLVRQIAPAFQQTSGLKLDAERLREKGIVKLNLRYTKVTNEDVRDYMAANLSVNLYTVNEPWLYSILWCTGVPSVTSDSSHVLRKVPFPIWLMPPDEYRLIWITSDLISFIIIVGVFIFQNY HNDQWRLGSIRTYNPEQIMLSAAVRRSSRDVKIMKEKLIFSEINNGVETTDELSLCSENGYANEMVTPTDHRDTRLRMN

Subcellular Location

Description
Endomembrane system {By SimilarityUniProtKB:Q640M6}; Multi-pass membrane protein {Sequence Analysis}. Cytoplasm, perinuclear region {By SimilarityUniProtKB:Q640M6}. Cell projection, growth cone {By SimilarityUniProtKB:Q640M6}.
Position in the Nuclear Envelope
Location	Location ID	Description
Perinuclear Region	SL-0198	The perinuclear region is the cytoplasmic region just around the nucleus.
Membrane Topology
Topology	Source	Annotation Type
Transmembrane	UniProt	Sequence Analysis {ECO:0000255}
Assigned Ontology terms

Cellular Component	Endomembrane System (GO:0012505) Growth Cone (GO:0030426) Membrane (GO:0016020) Perinuclear Region Of Cytoplasm (GO:0048471) Plasma Membrane (GO:0005886)

Biology & Function

Description
Glycerophosphodiester phosphodiesterase that promotes cell cycle exit and drives spinal motor neuron differentiation (PubMed:16195461, PubMed:19766572, PubMed:23329048). Mediates the cleavage of glycosylphosphatidylinositol (GPI) anchor of target proteins: removes the GPI-anchor of RECK, leading to release RECK from the plasma membrane (PubMed:23329048). May contribute to the osmotic regulation of cellular glycerophosphocholine (By similarity). {By SimilarityUniProtKB:Q640M6, Experimental EvidencePubMed:16195461, Experimental EvidencePubMed:19766572, Experimental EvidencePubMed:23329048}.
Assigned Ontology terms

Biological Process	Lipid Metabolic Process (GO:0006629) Nervous System Development (GO:0007399) Positive Regulation Of Neuron Differentiation (GO:0045666)
Molecular Function	Glycerophosphocholine Phosphodiesterase Activity (GO:0047389) Glycerophosphodiester Phosphodiesterase Activity (GO:0008889) Phosphatidylinositol Phospholipase C Activity (GO:0004435)

Protein-Protein Interactions

Interactions with other proteins (3 interactors)

Partner (UniProt)		IntAct	Confidence score
P0CB50	Peroxiredoxin-1 (EC 1.11.1.24) (Thioredoxin-dependent peroxiredoxin 1)	EBI-2464235	0.59
Q06830	Peroxiredoxin-1 (EC 1.11.1.24) (Natural killer cell-enhancing factor A) (NKEF-A) (Proliferation-associated gene protein) (PAG) (Thioredoxin peroxidase 2) (Thioredoxin-dependent peroxide reductase 2) (Thioredoxin-dependent peroxiredoxin 1)	EBI-2464259	0.40
P35700	Peroxiredoxin-1 (EC 1.11.1.24) (Macrophage 23 kDa stress protein) (Osteoblast-specific factor 3) (OSF-3) (Thioredoxin peroxidase 2) (Thioredoxin-dependent peroxide reductase 2) (Thioredoxin-dependent peroxiredoxin 1)	EBI-2464725	0.40

Cross-References

Database	Links
UNIPROT	Q3KTM2
Pfam	PF03009
PROSITE	PS51704

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