National and Kapodistrian University of Athens
Department of Biology
Biophysics & Bioinformatics Laboratory
Protein Information |
|
|---|---|
| Protein Name | 2-acylglycerol O-acyltransferase 2 |
| Accession Code | Q3SYC2 |
| Gene | MOGAT2 |
| Organism | Homo sapiens | Human (Taxonomy: 9606) |
| Part of Reference Proteome? | Yes |
| Sequence (Length: 334) |
Description |
Position in the Nuclear Envelope |
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|---|---|---|
| Location | Location ID | Description |
| Perinuclear Region | SL-0198 | The perinuclear region is the cytoplasmic region just around the nucleus. | Membrane Topology |
| Topology | Source | Annotation Type |
| Transmembrane | UniProt | Sequence Analysis {ECO:0000255} | Assigned Ontology terms |
Description |
|
|---|---|
| Catalyzes the formation of diacylglycerol from 2- monoacylglycerol and fatty acyl-CoA. Has a preference toward monoacylglycerols containing unsaturated fatty acids in an order of C18:3 > C18:2 > C18:1 > C18:0. Plays a central role in absorption of dietary fat in the small intestine by catalyzing the resynthesis of triacylglycerol in enterocytes. May play a role in diet-induced obesity. Also able to use 1-monoalkylglycerol (1-MAkG) as an acyl acceptor for the synthesis of monoalkyl-monoacylglycerol (MAMAG) (PubMed:28420705). {Experimental EvidencePubMed:12621063, Experimental EvidencePubMed:27184406, Experimental EvidencePubMed:28420705}. | Assigned Ontology terms |
Interactions with other proteins (1 interactors) |
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|---|---|---|---|
Database | Links |
| UNIPROT | Q3SYC2 A8K7I3 Q3SYC1 Q6ZQZ2 Q86UH6 Q9H630 |
| Pfam | PF03982 |
| OMIM | 610270 |
| DisGeNET | 80168 |
National and Kapodistrian University of Athens
Department of Biology
Biophysics & Bioinformatics Laboratory