NucEnvDB

NucEnvDB

A database of Nuclear Envelope Proteins and their Interactions

E3 ubiquitin-protein ligase RNF180 - Mus musculus - NucEnvDB

E3 ubiquitin-protein ligase RNF180 (Mus musculus)

FASTA TEXT XML

Subcellular Location Biology & Function Cross-References

General Information

Protein Information
Protein Name	E3 ubiquitin-protein ligase RNF180
Accession Code	Q3U827
Gene	Rnf180
Organism	Mus musculus \| House mouse (Taxonomy: 10090)
Part of Reference Proteome?	Yes
Sequence (Length: 592)
MKRSEESTSTQSPEEQTGTLHCWRCRKCIASSGCFMTPLETQVVEQDRHESVDAQNTCHLWHMNVDALPEWISCLLQKAQWTVGKLNCPFCGARLGGFNFVSTPKCSCGQLAAVHLCKSRTDHQAAQGGR LMRPALKHLPHPGVPSGCDKETLLTGGGSKTRNHWLLSMARNSNGLGRLTEALCLEVRATYFEMKNEKLLFKASDPKCQPFVPQPDTGRCPSRASHRKSHSLDLNISEKLILLPTLYEIHRKPTAYPRLN ETGPIDLSGLALPCSNSSCSFQSPPSFDPNMLLHRLSVAPHETQAQRGRECQCGLEASSVYSDHANANSLPFLMDLPSAGRSVLEASDQEEHLSQLDFLRSASFPLGTINHRLNNRERSKLRTLRRQQRR ERWLQKQGKYSGVGLLDHMTVSNEMSTDEETEFPEEKDSYMCAVCLDVYFNPYMCYPCHHIFCEPCLRTLAKDNPASTPCPLCRTIISRVFLQTELNNATKTFFTKEYLKIKQSFQKSSSAKWPLPSCRK GFHLFGGFHRRAAPVTRRQFPHGAHRMDYLHFEDDSRGWWFDMDMVIIYIYSVNWVIGFVVFCFLCYFFFPF

Subcellular Location

Description
Endoplasmic reticulum membrane {Experimental EvidencePubMed:18363970}; Single-pass membrane protein {Experimental EvidencePubMed:18363970}. Nucleus envelope {Experimental EvidencePubMed:18363970}.
Position in the Nuclear Envelope
Location	Location ID	Description
Nuclear Envelope	SL-0178	The nuclear envelope is a membrane system which surrounds the nucleoplasm of eukaryotic cells. It is composed of the nuclear lamina, nuclear pore complexes and two nuclear membranes. The space between the two membranes is called the nuclear intermembrane space.
Membrane Topology
Topology	Source	Annotation Type
Transmembrane	UniProt	Sequence Analysis {ECO:0000255}
Assigned Ontology terms

Cellular Component	Obsolete Intrinsic Component Of Endoplasmic Reticulum Membrane (GO:0031227) Nuclear Envelope (GO:0005635)

Biology & Function

Description
E3 ubiquitin-protein ligase which promotes polyubiquitination and degradation by the proteasome pathway of ZIC2. {Experimental EvidencePubMed:18363970}.
Assigned Ontology terms

Biological Process	Adult Behavior (GO:0030534) Norepinephrine Metabolic Process (GO:0042415) Organic Cyclic Compound Metabolic Process (GO:1901360) Positive Regulation Of Proteasomal Ubiquitin-Dependent Protein Catabolic Process (GO:0032436) Positive Regulation Of Protein Ubiquitination (GO:0031398) Protein Polyubiquitination (GO:0000209) Regulation Of Catalytic Activity (GO:0050790) Serotonin Metabolic Process (GO:0042428)
Molecular Function	Metal Ion Binding (GO:0046872) Ubiquitin Conjugating Enzyme Binding (GO:0031624) Ubiquitin Protein Ligase Activity (GO:0061630)

Cross-References

Database	Links
UNIPROT	Q3U827 Q3UW39 Q80ZX1 Q8CCR1 Q9CXV6
Pfam	PF19332
PROSITE	PS00518 PS50089

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