NucEnvDB

NucEnvDB

A database of Nuclear Envelope Proteins and their Interactions

Sorbin and SH3 domain-containing protein 2 - Mus musculus - NucEnvDB

Sorbin and SH3 domain-containing protein 2 (Mus musculus)

FASTA TEXT XML

Subcellular Location Biology & Function Interactions Cross-References

General Information

Protein Information
Protein Name	Sorbin and SH3 domain-containing protein 2
Accession Code	Q3UTJ2
Gene	Sorbs2
Organism	Mus musculus \| House mouse (Taxonomy: 10090)
Part of Reference Proteome?	Yes
Sequence (Length: 1180)
MNTDSGGCARKRAAMSVTLTSVKRVQSSPNLLAAGRESQSPDSAWRSYNDRNPETLNGDATYSSLAAKGFRSVRPNLQDKRSPTQSQITINGNSGGAVSPVSYYQRPFSPSAYSLPASLNSSIIMQHGRS LDSAETYSQHAQSLDGTMGSSIPLYRSSEEEKRVTVIKAPHYPGIGPVDESGIPTAIRTTVDRPKDWYKTMFKQIHMVHKPGLYNSPYSAQSHPAAKTQTYRPLSKSHSDNGTDAFKEVPSPVPPPHVPP RPRDQSSTLKHDWDPPDRKVDTRKFRSEPRSIFEYEPGKSSILQHERPVSIYQSSIDRSLERPSSSASMAGDFRKRRKSEPAVGPLRGLGDQSSSRTSPGRADLPGSSSTFTKSFISSSPSSPSRAQGGD DSKMCPPLCSYSGLNGTPSGELECCNAYRQHLDVPGDSQRAITFKNGWQMARQNAEIWSSTEETVSPKIKSRSCDDLLNDDCDSFPDPKTKSESMGSLLCEEDSKESCPMTWASPYIQEVCGNSRSRLKH RSAHNAPGFLKMYKKMHRINRKDLMNSEVICSVKSRILQYEKEQQHRGLLHGWSQSSTEEVPRDVVPTRISEFEKLIQKSKSMPNLGDEMLSPITLEPPQNGLCPKRRFSIESLLEEETQVRHPSQGQRS CKSNTLVPIHIEVTSDEQPRTHMEFSDSDQDGVVSDHSDYVHVEGSSFCSESDFDHFSFTSSESFYGSSHHHHHHHHHHRHLISSCKGRCPASYTRFTTMLKHERAKHENMDRPRRQEMDPGLSKLAFLV SPVPFRRKKILTPQKQTEKAKCKASVVEALDSALKDICDQIKAEKRRGSLPDNSILHRLISELLPQIPERNSSLHALKRSPMHQPFHPLPPDGASHCPLYQNDCGRMPHSASFPDVDTTSNYHAQDYGSA LSLQDHESPRSYSSTLTDLGRSASRERRGTPEKEKLPAKAVYDFKAQTSKELSFKKGDTVYILRKIDQNWYEGEHHGRVGIFPISYVEKLTPPEKAQPARPPPPVQPGEIGEAIAKYNFNADTNVELSLR KGDRIILLKRVDQNWYEGKIPGTNRQGIFPVSYVEVVKRNAKGAEDYPDPPLPHSYSSDRIYTLSSNKPQRPGFSHENIQGGGEPFQALYNYTPRNEDELELRESDVVDVMEKCDDGWFVGTSRRTKFFG TFPGNYVKRL

Subcellular Location

Description
Cytoplasm, perinuclear region {By Similarity}. Cytoplasm, myofibril, sarcomere, Z line {By Similarity}. Apical cell membrane {By Similarity\|UniProtKB:O94875}. Cell junction, focal adhesion {By Similarity\|UniProtKB:O94875}. Cell projection, lamellipodium {By Similarity\|UniProtKB:O94875}. Cytoplasm, cytoskeleton {By Similarity}. Note=Found at the Z line sarcomeres, stress fibers, dense bodies and focal adhesion. In pancreatic acinar cells, localized preferentially to the apical membrane. Colocalized with vinculin and filamentous actin at focal adhesions and lamellipodia of pancreatic cells. {By Similarity, By Similarity\|UniProtKB:O94875}.
Position in the Nuclear Envelope
Location	Location ID	Description
Perinuclear Region	SL-0198	The perinuclear region is the cytoplasmic region just around the nucleus.
Membrane Topology
Topology	Source	Annotation Type
Unknown	UniProt	Sequence Analysis
Assigned Ontology terms

Cellular Component	Apical Plasma Membrane (GO:0016324) Cytoskeleton (GO:0005856) Dendrite (GO:0030425) Focal Adhesion (GO:0005925) Lamellipodium (GO:0030027) Neuronal Cell Body (GO:0043025) Perinuclear Region Of Cytoplasm (GO:0048471) Plasma Membrane (GO:0005886) Postsynaptic Density (GO:0014069) Synapse (GO:0045202) Z Disc (GO:0030018)

Biology & Function

Description
Adapter protein that plays a role in the assembling of signaling complexes, being a link between ABL kinases and actin cytoskeleton. Can form complex with ABL1 and CBL, thus promoting ubiquitination and degradation of ABL1 (By similarity). May play a role in the regulation of pancreatic cell adhesion, possibly by acting on WASF1 phosphorylation, enhancing phosphorylation by ABL1, as well as dephosphorylation by PTPN12 (By similarity). {By Similarity, By Similarity\|UniProtKB:O94875}.
Assigned Ontology terms

Biological Process	Acetylcholine Receptor Signaling Pathway (GO:0095500) Actin Filament Organization (GO:0007015) Cell Growth Involved In Cardiac Muscle Cell Development (GO:0061049) Notch Signaling Pathway (GO:0007219) Regulation Of Skeletal Muscle Acetylcholine-Gated Channel Clustering (GO:1904393)
Molecular Function	Identical Protein Binding (GO:0042802) Protein Domain Specific Binding (GO:0019904)

Protein-Protein Interactions

Interactions with other proteins (10 interactors)

Partner (UniProt)		IntAct	Confidence score
Q7TPH6	E3 ubiquitin-protein ligase MYCBP2 (EC 2.3.2.33) (Myc-binding protein 2) (Pam/highwire/rpm-1 protein) (Protein Magellan) (Protein associated with Myc)	EBI-16731507	0.35
Q80YT7	Myomegalin (Phosphodiesterase 4D-interacting protein)	EBI-16732484	0.35
P83510	Traf2 and NCK-interacting protein kinase (EC 2.7.11.1)	EBI-16734044	0.35
Q62108	Disks large homolog 4 (Postsynaptic density protein 95) (PSD-95) (Synapse-associated protein 90) (SAP-90) (SAP90)	EBI-16724752	0.35
Q9D415	Disks large-associated protein 1 (DAP-1) (Guanylate kinase-associated protein) (PSD-95/SAP90-binding protein 1) (SAP90/PSD-95-associated protein 1) (SAPAP1)	EBI-16725590	0.35
Q3UHD9	Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 (AGAP-2) (Centaurin-gamma-1) (Cnt-g1) (Phosphatidylinositol 3-kinase enhancer) (PIKE)	EBI-16736255	0.35
P51637	Caveolin-3 (M-caveolin)	EBI-20565496	0.35
A2AKD7	Alpha-1-syntrophin	EBI-20566393	0.35
Q9QWI6	SRC kinase signaling inhibitor 1 (SNAP-25-interacting protein) (SNIP) (p130Cas-associated protein) (p140Cap)	EBI-27100778	0.35
P16056	Hepatocyte growth factor receptor (HGF receptor) (EC 2.7.10.1) (HGF/SF receptor) (Proto-oncogene c-Met) (Scatter factor receptor) (SF receptor) (Tyrosine-protein kinase Met)	EBI-27118288	0.35

Cross-References

Database	Links
UNIPROT	Q3UTJ2 Q3USC6 Q80TS1 Q8BJL6 Q8BJU3 Q8BLW9 Q8BX47 Q8CHU0
Pfam	PF00018 PF14604 PF02208
PROSITE	PS50002 PS50831

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