National and Kapodistrian University of Athens
Department of Biology
Biophysics & Bioinformatics Laboratory
Protein Information |
|
|---|---|
| Protein Name | Cyclin-dependent kinase 5 activator 1, p25 |
| Accession Code | Q4KYY2 |
| Gene | CDK5R1 |
| Organism | Spermophilus citellus | European suslik (Taxonomy: 9997) |
| Part of Reference Proteome? | No |
| Sequence (Length: 307) |
Description |
Position in the Nuclear Envelope |
|
|---|---|---|
| Location | Location ID | Description |
| Perinuclear Region | SL-0198 | The perinuclear region is the cytoplasmic region just around the nucleus. | Membrane Topology |
| Topology | Source | Annotation Type |
| Lipid-Anchored | UniProt | By Similarity {ECO:0000250|UniProtKB:Q15078} | Assigned Ontology terms |
Description |
|
|---|---|
| p35 is a neuron specific activator of CDK5. The complex p35/CDK5 is required for neurite outgrowth and cortical lamination. Involved in dendritic spine morphogenesis by mediating the EFNA1-EPHA4 signaling. Activator of TPKII. The complex p35/CDK5 participates in the regulation of the circadian clock by modulating the function of CLOCK protein: phosphorylates CLOCK at 'Thr-451' and 'Thr-461' and regulates the transcriptional activity of the CLOCK-ARNTL/BMAL1 heterodimer in association with altered stability and subcellular distribution. {By SimilarityUniProtKB:Q15078}. | Assigned Ontology terms |
National and Kapodistrian University of Athens
Department of Biology
Biophysics & Bioinformatics Laboratory