NucEnvDB

NucEnvDB

A database of Nuclear Envelope Proteins and their Interactions

DnaJ homolog subfamily A member 1 homolog - Dictyostelium discoideum - NucEnvDB

DnaJ homolog subfamily A member 1 homolog (Dictyostelium discoideum)

FASTA TEXT XML

Subcellular Location Biology & Function Cross-References

General Information

Protein Information
Protein Name	DnaJ homolog subfamily A member 1 homolog
Accession Code	Q54ED3
Gene	dnaja1
Organism	Dictyostelium discoideum (Taxonomy: 44689)
Part of Reference Proteome?	Yes
Sequence (Length: 459)
MVKEKEYYERLGVKPDCTEDELKKAYRKMAVKYHPDKNQGPGKDAAEAKFKDISEAYEVLSDPEKRKMYDSYGSEGMKESGFHASSAEDLFSHFFGAGGGGGGFSFGGGGGDDFGGFSFGNMGGMGGMGG MGGGHKKRRKGEDIEHEMNRSLEELYNGKLVKISISRDEVCKTCKGSGSNKPGVTTTCPTCNGSRYVFQKKQVGPGMIQQVQTACHTCHGTGEKIKEEDKCKECKGKRVIQGKKIVQFQVEKGTRDGERI MLQGQGSEYPGVPPGDVIITIREKPNVNFKRNGDNLIYTKRLKLLDSIAGSQFIINTLDQRKLWVNHEKGDIIKQGDMRYIENEGMPIKGTSRKGKLIIAFDIEYPSNLTNDDIEKLSKILPKAATPSVS KSDCKSVGLSKVNFNTNEQSSHGGAGGAYQQHGGAYGHQKQQQQGFNPADFGAQFGGGGPQQAQQCQQQ

Subcellular Location

Description
Membrane {Curator Inference}; Lipid-anchor {Curator Inference}. Cytoplasm {ECO:0000250}. Microsome {ECO:0000250}. Mitochondrion {ECO:0000250}. Nucleus {ECO:0000250}. Cytoplasm, perinuclear region {ECO:0000250}. Note=Primarily cytoplasmic and associated with microsomes. A minor proportion is associated with nuclei and mitochondria (By similarity). {ECO:0000250}.
Position in the Nuclear Envelope
Location	Location ID	Description
Perinuclear Region	SL-0198	The perinuclear region is the cytoplasmic region just around the nucleus.
Membrane Topology
Topology	Source	Annotation Type
Lipid-Anchored	UniProt	Sequence Analysis {ECO:0000255}
Assigned Ontology terms

Cellular Component	Cytoplasm (GO:0005737) Cytosol (GO:0005829) Endoplasmic Reticulum (GO:0005783) Membrane (GO:0016020) Mitochondrion (GO:0005739) Nucleus (GO:0005634) Perinuclear Region Of Cytoplasm (GO:0048471)

Biology & Function

Description
Co-chaperone for Hsp70 family members. Plays a role in protein transport into mitochondria and in the regulation of apoptosis via its role as co-chaperone (By similarity). {By Similarity}.
Assigned Ontology terms

Biological Process	Protein Refolding (GO:0042026) Response To Heat (GO:0009408)
Molecular Function	ATP Binding (GO:0005524) Chaperone Binding (GO:0051087) Hsp70 Protein Binding (GO:0030544) Metal Ion Binding (GO:0046872) Unfolded Protein Binding (GO:0051082)

Cross-References

Database	Links
UNIPROT	Q54ED3
Pfam	PF00226 PF01556 PF00684
PROSITE	PS00636 PS50076 PS51188

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