NucEnvDB

NucEnvDB

A database of Nuclear Envelope Proteins and their Interactions

C-Jun-amino-terminal kinase-interacting protein 4 - Mus musculus - NucEnvDB

C-Jun-amino-terminal kinase-interacting protein 4 (Mus musculus)

FASTA TEXT XML

Subcellular Location Biology & Function Interactions Cross-References

General Information

Protein Information
Protein Name	C-Jun-amino-terminal kinase-interacting protein 4
Accession Code	Q58A65
Gene	Spag9
Organism	Mus musculus \| House mouse (Taxonomy: 10090)
Part of Reference Proteome?	Yes
Sequence (Length: 1321)
MELEDGVVYQEEPGGSGAVMSERVSGLAGSIYREFERLIGRYDEEVVKELMPLVVAVLENLDSVFAQDQEHQVELELLRDDNEQLITQYEREKALRKHAEEKFIEFEDSQEQEKKDLQTRVESLESQTRQ LELKAKNYADQISRLEEREAELKKEYNALHQRHTEMIHNYMEHLERTKLHQLSGSDQLEATAHSRIRKERPISLGIFPLPAGDGLLTPDTQKGGETPGSEQWKFQELSQPRSHTSLKVSHSPEPPKAVEQ EDELSDISQGGSKATTPASTANSDVSAIPPDTPSKEDNEGFVKGTDTSNKSEISKHIEVQVAQETRNVSTESGENEEKSEVQAIIESTPELDMDKDLSGYKGSSTPTKGIENKAFDRNTESLFEELSSAG SGLIGDVDEGADLLGMGREVENLILENTQLLETKNALNVVKNDLIAKVDELTCEKDVLQGELEAVKQAKLKLEDKNRELEEELRKARAEAEDARQKAKDDDDSDIPTAQRKRFTRVEMARVLMERNQYKE RLMELQEAVRWTEMIRASRENPAMQEKKRSSIWQFFSRLFSSSSNATKKPEPPVNLKYNAPTSHVTPSVKKRSSTLSQLPGDKSKAFDFLSEETEASLASRREQKREQYRQVKAHVQKEDGRVQAFGWSL PQKYKQVANGQGETKMKNLPVPVYLRPLDEKDASMKLWCAVGVNLSGGKTRDGGSVVGASVFYKDIAGLDTEGSKQRSASQSSLDKLDQELKEQQKEFKNQEELSSQVWICTSTHSTTKVIIIDAVQPGN ILDSFTVCNSHVLCIASVPGARETDYPAGEELSESGQVDKASLCGSMTSNSSAEMDSLLGGITVVGCSTEGLTGAATSPSTNGASPVIEKPPEMETENSEVDENIPTAEEATEATEGNAGSTEDTVDISQ PGVYTEHVFTDPLGVQIPEDLSPVFQSSNDSDVYKDQISVLPNEQDLAREEAQKMSSLLPTMWLGAQNGCLYVHSSVAQWRKCLHSIKLKDSILSIVHVKGIVLVALADGTLAIFHRGVDGQWDLSNYHL LDLGRPHHSIRCMTVVHDKVWCGYRNKIYVVQPKAMKIEKSFDAHPRKESQVRQLAWVGDGVWVSIRLDSTLRLYHAHTYQHLQDVDIEPYVSKMLGTGKLGFSFVRITALMVSCNRLWVGTGNGVIISI PLTETNKTSGTPGNRPGSVIRVYGDENSDKVTPGTFIPYCSMAHAQLCFHGHRDAVKFFVAVPGQVISPQSSSGGADLTADKAGSSAQEPSSQTPLKSMLVISGGEGYIDFRMGDEGGESELLGEDLPLE PSVTKAERSHLIVWQVMCGNE

Subcellular Location

Description
Cytoplasm {Experimental EvidencePubMed:12391307, Experimental EvidencePubMed:15767678, Experimental EvidencePubMed:19056739}. Cytoplasm, perinuclear region {Experimental EvidencePubMed:12391307, Experimental EvidencePubMed:19056739}. Lysosome membrane {ECO:0000250\|UniProtKB:O60271}. Note=Perinuclear distribution in response to stress signals such as UV radiation. {Experimental EvidencePubMed:12391307}.
Position in the Nuclear Envelope
Location	Location ID	Description
Perinuclear Region	SL-0198	The perinuclear region is the cytoplasmic region just around the nucleus.
Membrane Topology
Topology	Source	Annotation Type
Unknown	UniProt	Sequence Analysis
Assigned Ontology terms

Cellular Component	Centriolar Satellite (GO:0034451) Cytoplasm (GO:0005737) Cytosol (GO:0005829) Lysosomal Membrane (GO:0005765) Perinuclear Region Of Cytoplasm (GO:0048471)

Biology & Function

Description
The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module (PubMed:12391307, PubMed:15767678). Regulates lysosomal positioning by acting as an adapter protein which links PIP4P1-positive lysosomes to the dynein-dynactin complex (By similarity). Assists PIKFYVE selective functionality in microtubule-based endosome-to-TGN trafficking (PubMed:19056739). {By SimilarityUniProtKB:O60271, Experimental EvidencePubMed:12391307, Experimental EvidencePubMed:15767678, Experimental EvidencePubMed:19056739}.
Assigned Ontology terms

Biological Process	Lysosome Localization (GO:0032418) Negative Regulation Of Dendrite Extension (GO:1903860) Negative Regulation Of Neuron Differentiation (GO:0045665) Negative Regulation Of Protein Phosphorylation (GO:0001933) Positive Regulation Of Cell Migration (GO:0030335) Positive Regulation Of MAPK Cascade (GO:0043410) Positive Regulation Of Neuron Differentiation (GO:0045666) Retrograde Transport, Endosome To Golgi (GO:0042147) Striated Muscle Cell Differentiation (GO:0051146) Vesicle-Mediated Transport (GO:0016192)
Molecular Function	Identical Protein Binding (GO:0042802) JUN Kinase Binding (GO:0008432) Kinesin Binding (GO:0019894) MAP-Kinase Scaffold Activity (GO:0005078) Signaling Receptor Complex Adaptor Activity (GO:0030159)

Protein-Protein Interactions

Interactions with other proteins (3 interactors)

Partner (UniProt)		IntAct	Confidence score
O88447	Kinesin light chain 1 (KLC 1)	EBI-7681081	0.58
P62331	ADP-ribosylation factor 6 (EC 3.6.5.2)	EBI-7986227	0.60
Q5S007	Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1) (EC 3.6.5.-) (Dardarin)	EBI-6530261	0.40

Cross-References

Database	Links
UNIPROT	Q58A65 Q3UH77 Q3UHF0 Q58VQ4 Q5NC70 Q5NC78 Q6A057 Q6PAS3 Q8CJC2
Pfam	PF16471 PF09744
PROSITE	PS51776 PS51777

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