NucEnvDB

NucEnvDB

A database of Nuclear Envelope Proteins and their Interactions

Keratin, type I cytoskeletal 18 - Rattus norvegicus - NucEnvDB

Keratin, type I cytoskeletal 18 (Rattus norvegicus)

FASTA TEXT XML

Subcellular Location Biology & Function Interactions Cross-References

General Information

Protein Information
Protein Name	Keratin, type I cytoskeletal 18
Accession Code	Q5BJY9
Gene	Krt18
Organism	Rattus norvegicus \| Norway rat (Taxonomy: 10116)
Part of Reference Proteome?	Yes
Sequence (Length: 423)
MSFTTRSTTFSTNYRSLGSVRTPSQRVRPASSAASVYAGAGGSGSRISVSRSVWGGSVGSAGLAGMGGVQTEKETMQDLNDRLASYLDKVKNLETENRRLESKIREYLEKRGPQGVRDWGHYFKTIEDLR AQIFANSVDNARIVLQIDNARLAADDFRVKYETELAMRQSVESDIHGLRKVVDDTNITRLQLETEIEALKEELLFMKKNHEEEVQGLEAQIASSGLTVEVDAPKSQDLSKIMADIRAQYEQLAQKNREEL DKYWSQQIEESTTVVTTKSAEIRDAETTLLELRRTLQTLEIDLDSMKNQNINLENNLGEVEARYRVQMEQLNGVLLHLESELAQTRAEGQRQTQEYEALLNIKVKLEAEIATYRRLLEDGDDFSLNDALD SSNSMQTVQRTTTRKVVDGKVVSETNDTRVLRH

Subcellular Location

Description
Nucleus matrix {Experimental EvidencePubMed:16128803, Experimental EvidencePubMed:16998620}. Cytoplasm, perinuclear region {By SimilarityUniProtKB:P05783}. Nucleus, nucleolus {By SimilarityUniProtKB:P05783}. Cytoplasm {Experimental EvidencePubMed:16128803, Experimental EvidencePubMed:16998620}.
Position in the Nuclear Envelope
Location	Location ID	Description
Perinuclear Region	SL-0198	The perinuclear region is the cytoplasmic region just around the nucleus.
Membrane Topology
Topology	Source	Annotation Type
Unknown	UniProt	Sequence Analysis
Assigned Ontology terms

Cellular Component	Cell Periphery (GO:0071944) Centriolar Satellite (GO:0034451) Cytoplasm (GO:0005737) Cytoskeleton (GO:0005856) External Side Of Plasma Membrane (GO:0009897) Extracellular Space (GO:0005615) Intermediate Filament (GO:0005882) Keratin Filament (GO:0045095) Microtubule Organizing Center (GO:0005815) Nuclear Matrix (GO:0016363) Nucleolus (GO:0005730) Plasma Membrane (GO:0005886) Protein-Containing Complex (GO:0032991)

Biology & Function

Description
When phosphorylated, plays a role in filament reorganization. Involved in the delivery of mutated CFTR to the plasma membrane. Together with KRT8, is involved in interleukin-6 (IL-6)-mediated barrier protection (By similarity). Involved in the uptake of thrombin- antithrombin complexes by hepatic cells. {By SimilarityUniProtKB:P05783, Experimental EvidencePubMed:9353322}.
Assigned Ontology terms

Biological Process	Cholangiocyte Apoptotic Process (GO:1902488) Extrinsic Apoptotic Signaling Pathway (GO:0097191) Obsolete Golgi To Plasma Membrane CFTR Protein Transport (GO:0043000) Hepatocyte Apoptotic Process (GO:0097284) Hepatocyte Differentiation (GO:0070365) Intermediate Filament Cytoskeleton Organization (GO:0045104) Mesenchymal Stem Cell Differentiation (GO:0072497) Negative Regulation Of Apoptotic Process (GO:0043066) Response To Fructose (GO:0009750) Response To Nutrient Levels (GO:0031667) Tumor Necrosis Factor-Mediated Signaling Pathway (GO:0033209)
Molecular Function	Scaffold Protein Binding (GO:0097110) Structural Molecule Activity (GO:0005198)

Protein-Protein Interactions

Interactions with other proteins (2 interactors)

Partner (UniProt)		IntAct	Confidence score
P54645	5'-AMP-activated protein kinase catalytic subunit alpha-1 (AMPK subunit alpha-1) (EC 2.7.11.1) (Acetyl-CoA carboxylase kinase) (ACACA kinase) (EC 2.7.11.27) (Hydroxymethylglutaryl-CoA reductase kinase) (HMGCR kinase) (EC 2.7.11.31) (Tau-protein kinase PRKAA1) (EC 2.7.11.26)	EBI-16399805	0.35
P80386	5'-AMP-activated protein kinase subunit beta-1 (AMPK subunit beta-1) (AMPKb) (5'-AMP-activated protein kinase 40 kDa subunit)	EBI-16400563	0.35

Cross-References

Database	Links
UNIPROT	Q5BJY9 Q63278
Pfam	PF00038
PROSITE	PS00226 PS51842

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